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Ligament support and preparation method thereof

A technology of ligament and silk fibroin, which is applied in the field of medical devices to achieve the effect of uniform microstructure

Inactive Publication Date: 2014-09-17
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above existing problems, the purpose of the present invention is to solve the defects existing in the existing ligament scaffolds, using silk fibroin composite medical polymer synthetic materials as materials, to provide a fiber orientation and uniform voids, which meet the requirements of mechanical properties Three-dimensional structured ligament scaffold and its preparation method

Method used

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  • Ligament support and preparation method thereof

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Effect test

preparation example Construction

[0017] Preparation of ligament support, prepare silk fibroin solution or silk fibroin powder dispersion and medical polymer synthetic material polyvinyl alcohol (PVA) solution or polyurethane (PU) solution or polycaprolactone solution (PCL) or polyurethane ( PU) and polycaprolactone (PCL) mixed solution, proceed as follows:

[0018] a Take silk fibroin protein solution or silk fibroin powder dispersion liquid and mix with medical polymer synthetic material solution, obtain the mass ratio of silk fibroin protein and medical polymer synthetic material is 1 / 20~1 / 1, silk fibroin and medical polymer synthetic material The total solute mass concentration of the polymer synthetic material is a mixed solution of 7% to 15%, and the mixed solution is sucked into a spinning liquid pipe for electrospinning.

[0019] b To build an electrospinning device, fix a collection wheel with a circumference 1 to 3 times the length of the ligament to be prepared on an adjustable-speed conductive rota...

Embodiment 1

[0027] a with hexafluoroisopropanol as a solvent, a silk fibroin solution with a mass concentration of 5%, and N,N-dimethylformamide as a solvent with a mass concentration of 20% polyurethane (PU) solution to mix to obtain silk fibroin and The mass ratio of medical polymer synthetic material polyurethane (PU) is 1 / 20, the total solute mass concentration of silk fibroin and medical polymer synthetic material polyurethane (PU) is a mixed solution of 7%, and the mixed solution is sucked into the electrospinning spinning solution tube.

[0028] b To build the electrospinning device, fix the collection wheel with a circumference of 1 times the length of the ligament to be prepared on the adjustable-speed conductive rotating body. The collecting wheel and the conductive rotating body are on the same axis, and the collecting wheel is made of electrically insulating material. , the thickness of the collection wheel is 1 mm, and the two sides of the collection wheel are respectively ad...

Embodiment 2

[0032] a is that hexafluoroisopropanol is a solvent and a silk fibroin solution with a mass concentration of 10% is mixed with dimethylacetamide as a solvent with a mass concentration of 10% polycaprolactone (PCL) solution to obtain silk fibroin and medical The mass ratio of polymer synthetic material polycaprolactone (PCL) is 1 / 10, and the total solute mass concentration of silk fibroin and medical polymer synthetic material polycaprolactone (PCL) is a mixed solution of 10%, and will be mixed The solution is sucked into the dope tube for electrospinning.

[0033] b Build the electrospinning device, fix the collection wheel with a circumference twice the length of the ligament to be prepared on the adjustable-speed conductive rotating body, the collecting wheel and the conductive rotating body are on the same axis, and the collecting wheel is made of electrically insulating material , the thickness of the collection wheel is 3mm, the two sides of the collection wheel are respe...

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Abstract

The invention relates to a ligament support containing silk fibroin compound oriented nanofiber and a preparation method thereof, and belongs to the technical field of medical apparatus and instruments. The ligament support is prepared from oriented fiber combining silk fibroin with a medical high molecular synthetic material and has a porous three dimensional structure, the mass ratio of the silk fibroin and medical high molecular synthetic material in the compound oriented fiber is (1-20):(1-1), the diameter of the compound oriented fiber is 500nm-10000nm, the thickness of the ligament is 1mm-10mm, and the width of the ligament is 1mm-15mm. The ligament support has a uniform microstructure and good biocompatibility, provides a matrix structure for growing of ligament cells, and can be used for increasing the tensile strength of the ligament due to the compound fiber orientated structure. The ligament support is simple in preparation method and convenient to operate, the preparation process is controllable, and the preparation method is suitable for preparing the ligament supports of various sections and lengths.

Description

technical field [0001] The invention relates to a ligament support containing silk fibroin composite orientation nanofibers and a preparation method thereof, belonging to the technical field of medical devices. Background technique [0002] In daily work and sports, the probability of ligament injury is quite high, directly leading to joint instability and joint inflammation, which have become health problems that cannot be ignored, but the self-repair ability of ligaments is very poor. There are various methods for ligament repair, including autogenous tendon transplantation, allogeneic or heterogeneous tendon transplantation, and artificial ligament repair materials. Because allografts and xenografts have problems such as insufficient sources, high risks, and immune rejection, their clinical application is greatly limited. Therefore, replacing damaged ligaments with artificial ligament repair materials has become the mainstream ligament repair treatment. Artificial ligame...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/56A61L27/50D04H1/728D04H1/4382D06M13/224D06M13/144D06M13/123D06M101/10D06M101/38D06M101/30D06M101/24
Inventor 柏自奎韩素青王洪吴星火周应山顾绍金陶咏真杨红军张强许杰徐卫林
Owner WUHAN TEXTILE UNIV
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