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Hydrophilic lubricating antibacterial lacrimal duct tube and manufacturing method thereof

A lacrimal duct and antibacterial agent technology, applied in the medical field, can solve problems such as easy extubation breakage, lacrimal duct tissue adhesion, etc., achieve the effect of improving pushability and twist control, increasing the success rate of surgery, and promoting wound healing

Active Publication Date: 2014-09-17
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, in order to solve the problem that the existing artificial lacrimal duct tube is easy to adhere to the lacrimal duct tissue due to its rough surface and is easy to pull out the tube and break, it is still necessary to provide a lacrimal duct tube with long-term lubricating effect and antibacterial properties, which can resist cells and Tissue adhesion, reduce lacrimal duct and lacrimal duct adhesion, reduce the risk of bacterial infection, effectively solve the problems of broken tube and tissue fibrosis and hyperplasia in the process of pulling out the lacrimal duct, and relieve patients from worries

Method used

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  • Hydrophilic lubricating antibacterial lacrimal duct tube and manufacturing method thereof
  • Hydrophilic lubricating antibacterial lacrimal duct tube and manufacturing method thereof
  • Hydrophilic lubricating antibacterial lacrimal duct tube and manufacturing method thereof

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preparation example Construction

[0048] The preparation method of lacrimal duct of the present invention comprises the following steps:

[0049] (a) providing a basic lacrimal duct, the basic lacrimal duct includes a main tube body and a lifting ring tube body, wherein the upper end of the main tube body is connected to the lower end of the lifting ring tube body;

[0050] (b) The base lacrimal duct is treated with plasma treatment and silane coupling agent surface treatment in sequence, and then treated with an active reaction solution, the active reaction solution comprising: hydrophilic polymer, hydrophilic polymer monomer, antibacterial agent and Initiator;

[0051] (c) Initiating a polymerization reaction to form a composite functional layer on the tube wall of the main tube body and the pulling ring tube body, to obtain the lacrimal duct tube according to claim 1.

[0052] The hydrophilic lubricating antibacterial lacrimal duct prepared by the method has a uniform surface coating (composite functional ...

Embodiment 1

[0114] Prepare a solution of silane coupling agent KH792 with a concentration of 3% (w / w), use a mixed solution of ethanol and dichloromethane as the solvent, clean and dry the polyurethane-based lacrimal duct, and place it in the above-mentioned silane coupling agent solution Soak for 60 minutes, take it out and dry it naturally, and then put it in an oven at 120°C for 3 hours.

[0115] Prepare the active reaction solution: the solvent is a mixed solvent of methanol, dichloromethane and tetrahydrofuran, and the concentration of the active reaction solution is 6% (w / w), wherein PVP:VP:PEGDA:(M)AA=80:10:3:7 (weight ratio), the content of the iodine compound (iodophor) available iodine component is 1% (w / w), and the content of the initiator BPO is 0.5% (w / w).

[0116] Soak the above-mentioned basic lacrimal duct treated with silane coupling agent in the above-mentioned active reaction solution, react for 60 minutes, take it out, dry it for 30 minutes under the protection of nitr...

Embodiment 2

[0120] Prepare a solution of silane coupling agent KH570 with a concentration of 4% (w / w), use ethanol solution as the solvent, clean and dry the polyurethane-based lacrimal ducts, soak in the above-mentioned silane coupling agent solution for 40 minutes, and take it out Let it dry naturally, and then put it in an oven at 120°C for 3 hours.

[0121] Prepare active reaction solution: the solvent adopts the mixed solvent of methanol, cyclohexane, dimethylformamide and acetic acid, and the system concentration is 5% (w / w), wherein PVP-co-PHEMA:VP:PEGDA:HEMA=70: 15:5:10 (weight ratio), chitosan concentration is 2% (w / w), and initiator AIBN content is 1.0% (w / w).

[0122] Soak the above-mentioned basic lacrimal duct treated with silane coupling agent in the above-mentioned active reaction solution, react for 80 minutes, take it out, dry it under nitrogen protection for 50 minutes, and then continue to react at 70°C for 65 minutes under nitrogen protection, the lacrimal duct after r...

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Abstract

The invention relates to a hydrophilic lubricating antibacterial lacrimal duct tube and a manufacturing method of the hydrophilic lubricating antibacterial lacrimal duct tube. The lacrimal duct tube comprises a main tube and a lifting ring. The upper end of the main tube is connected with the lower end of the lifting ring. The main tube and the lifting ring respectively comprise a tube body and a composite function layer attached to the tube wall, wherein the composite function layer is used for resisting bacterial infection and reducing adhesion of the tube body to the lacrimal duct. A basic lacrimal duct tube is processed through plasma and subjected to silane coupling agent surface treatment sequentially and then treated through an active reaction solution, a polymerization reaction is triggered, the composite function layer is formed on the tube wall of the basic lacrimal duct tube, and then the hydrophilic lubricating antibacterial lacrimal duct tube is obtained. The hydrophilic lubricating antibacterial lacrimal duct tube has a uniform surface function coating and thus has durable lubricity, tissue adhesion resistance and a good antibacterial property in a moist state.

Description

technical field [0001] The invention belongs to the field of medical technology, and in particular relates to a hydrophilic lubricating antibacterial lacrimal duct and a preparation method thereof. Background technique [0002] In the treatment of lacrimal duct obstruction, the artificial lacrimal duct drainage tube is mainly used to anastomose and probing the occluded lacrimal duct. However, due to individual differences or improper extubation, fibrosis, hyperplasia, dacryocystitis or Then blockage and other problems. The surface lubrication and anti-tissue adhesion treatment of the artificial lacrimal duct can effectively reduce the damage to the surrounding tissue during the extubation operation and increase the success rate of the operation. A large number of clinical results show that the medical catheter modified by hydrophilic coating can not only reduce the pain of the patient, but also facilitate the operation of the doctor. [0003] There have been many reports a...

Claims

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Application Information

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IPC IPC(8): A61B17/115A61F2/82A61M25/00
CPCA61F2/82A61L29/126A61L29/145A61L29/16A61L2300/104A61L2300/106A61L2300/232A61L2300/404A61L2300/412A61L2300/424A61M25/00A61M25/0009
Inventor 洪佳旭孙建国徐建江孙兴怀
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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