Antibacterial chitosan gel and preparation method thereof
A sugar gel, chitosan technology, applied in the direction of topical antibacterial agents, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of product effectiveness and safety restrictions, etc.
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Embodiment 1
[0080] Embodiment 1: the preparation of chitosan antibacterial gel
[0081] A, prepare the composite solution containing chitosan
[0082] Mix glacial acetic acid and distilled water evenly according to the weight ratio of 0.9:22, according to the weight ratio of high molecular weight chitosan and low molecular weight chitosan 1.8:2.6, add to the glacial acetic acid aqueous solution Molecular weight 60 x 10 sold under the tradename Food and Pharmaceutical Grade Chitosan 4 Da, high molecular weight chitosan with a degree of deacetylation of 88%, low molecular weight chitosan with a molecular weight of 800Da and a degree of deacetylation of 100% sold by Hebei Baiwei Biotechnology Co., Ltd. under the trade name Chitosan, stirred and dissolved, after homogenization Then add the polyoxyethylene lanolin ether sold by British Croda Company under the trade name polyoxyethylene lanolin ether according to the weight ratio of polyoxyethylene lanolin ether and chitosan total amount 1:4.8...
Embodiment 2
[0092] Embodiment 2: the preparation of chitosan antibacterial gel
[0093] A, prepare the composite solution containing chitosan
[0094] Mix glacial acetic acid and distilled water evenly according to the weight ratio of 0.8:16, according to the weight ratio of high molecular weight chitosan and low molecular weight chitosan 2.0:3.4, add to the glacial acetic acid aqueous solution Molecular weight 60 x 10 sold under the tradename Food and Pharmaceutical Grade Chitosan 4 Da, high molecular weight chitosan with 85% degree of deacetylation, low molecular weight chitosan with molecular weight 900Da and 98% degree of deacetylation sold by Hebei Baiwei Biotechnology Co., Ltd. under the trade name Chitosan, stirred and dissolved, after homogenization Then add the polyoxyethylene lanolin ether sold by British Woda Company under the trade name polyoxyethylene lanolin ether according to the weight ratio 1:5.2 of polyoxyethylene lanolin ether and chitosan total amount, stir evenly, ob...
Embodiment 3
[0104] Embodiment 3: the preparation of chitosan antibacterial gel
[0105] A, prepare the composite solution containing chitosan
[0106] Mix glacial acetic acid and distilled water evenly according to the weight ratio of 1.2:18, according to the weight ratio of high molecular weight chitosan and low molecular weight chitosan 2.2:3.2, add to the glacial acetic acid aqueous solution Molecular weight 60 x 10 sold under the tradename Food and Pharmaceutical Grade Chitosan 4 Da, high molecular weight chitosan with 92% degree of deacetylation, low molecular weight chitosan with molecular weight 960Da and 100% degree of deacetylation sold by Hebei Baiwei Biotechnology Co., Ltd. under the trade name chitosan, stirred and dissolved, after homogenization Then add the polyoxyethylene lanolin ether sold by British Croda Company under the trade name polyoxyethylene lanolin ether according to the weight ratio of polyoxyethylene lanolin ether and chitosan total amount 1:5.0, stir evenly, ...
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