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Total gingerol ointment for treating chilblain and preparation method thereof

A technology of total gingerol and ointment, which is applied in the field of ointment for treating chilblain and its preparation, can solve the problems of restricting drug development and application, inaccurate pharmacological efficacy, and inconspicuous therapeutic effect, and achieve precise pharmacological efficacy, Guaranteed quality and efficacy, the effect of easy-to-control quality

Active Publication Date: 2014-08-27
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine often uses nifedipine, pyridine, etc., which have relatively large toxic and side effects, ineffective therapeutic effect, and great dependence.
Most traditional Chinese medicines for frostbite exist in the form of traditional Chinese medicine compound, without index components, with inaccurate pharmacological effects and difficult quality control, which limits their development and application as medicines

Method used

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  • Total gingerol ointment for treating chilblain and preparation method thereof
  • Total gingerol ointment for treating chilblain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of total gingerol ointment for treating chilblain, made of total gingerol and auxiliary materials in the following weight ratio:

[0029] 2 parts of total gingerols, 50 parts of oily raw materials, emulsifier - 2 parts of glyceryl monostearate, humectant - 11 parts of propylene glycol, alkali agent - 0.5 parts of potassium hydroxide, preservative - salicylic acid 0.2 parts, antioxidant - 0.1 parts of sodium sulfite, 20 parts of water. Among them, the oily raw material is a mixture of 25 parts of stearic acid, 10 parts of lanolin and 15 parts of polyol-stearyl alcohol.

[0030] Wherein, total gingerol is made by following method:

[0031] A, extraction: the ginger 1kg after drying in the shade is sliced, then carry out 4 times of cold dipping extraction in solvent, after extraction, merge extract, evaporate solvent to extractum;

[0032] The solvent is an ethanol solution with a volume fraction of 50%. The weight-to-volume ratio of the ginger slices to the solve...

Embodiment 2

[0038] A kind of total gingerol ointment for treating chilblain, made of total gingerol and auxiliary materials in the following weight ratio:

[0039] 10 parts of total gingerols, 15 parts of oily raw materials, emulsifier - 1 part of propylene glycol monostearate, humectant - 4 parts of glycerin, alkali agent - 1 part of triethanolamine, preservative - p-hydroxybenzoic acid 0.15 parts of ethyl ester, 0.02 parts of sodium sulfite, an antioxidant, and 40 parts of water. Wherein the oily raw material is a mixture of 10 parts of grease-white oil and 5 parts of wax-beeswax.

[0040] Wherein, total gingerol is made by following method:

[0041] A. Extraction: grind 1 kg of dried ginger at 40°C into powder, then cold-soak and extract 3 times in a solvent, after extraction, combine the extracts, evaporate the solvent to extractum;

[0042] The solvent is an ethanol solution with a volume fraction of 95%. The weight-to-volume ratio of ginger powder to the solvent is 1kg:3L during e...

Embodiment 3

[0048] A kind of total gingerol ointment for treating chilblain, made of total gingerol and auxiliary materials in the following weight ratio:

[0049] 5 parts of total gingerols, 55 parts of oily raw materials, emulsifier - 5 parts of sorbitan monooleate (Span-80), humectant - 10 parts of glycerin, alkaline agent - 0.15 parts of potassium hydroxide , preservative - 0.12 parts of benzalkonium bromide, antioxidant - 0.1 part of ethylenediaminetetraacetic acid, 75 parts of water. The oily raw material is a mixture of 40 parts of butyl stearate and 15 parts of polyol-cetyl alcohol.

[0050] Wherein, total gingerol is made by following method:

[0051] A. Extraction: 1 kg of dried ginger is sliced, then cold soaked for 2 times in the solvent for extraction, after the extraction, the extract is combined and the solvent is evaporated to extractum;

[0052] The solvent is an ethanol solution with a volume fraction of 70%. The weight-to-volume ratio of the ginger slices to the solve...

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Abstract

The invention discloses a total gingerol ointment for treating chilblain. The total gingerol ointment is prepared from total gingerol and the following auxiliary materials in parts by weight: 2-30 parts of total gingerol, 15-70 parts of oil materials, 0-60 parts of waxes, 1-15 parts of emulsifier, 4-15 parts of humectant, 0.1-0.2 part of preservative, 0.005-0.2 part of antioxidant and 20-80 parts of water, wherein the oil materials are one or a mixture of two of grease and wax. Preparation steps for the total gingerol ointment are as follows: heating the oil materials and the emulsifier to 70-90 DEG C, and stirring to obtain an emulsified liquid; then, adding the humectant and the preservative into water, stirring continuously, and heating to 70-90 DEG C to form liquor; slowly mixing the liquor with the emulsified liquid, stirring and emulsifying, adding the antioxidant and the total gingerol while cooling to 40-50 DEG C, and uniformly stirring to prepare the ointment. The ointment disclosed by the invention is specific in active ingredient, exact in pharmacology and drug efficacy, easy to control, good in treatment effect for treating chilblain, and small in toxic and side effect.

Description

technical field [0001] The invention relates to an ointment for treating frostbite and a preparation method thereof. Background technique [0002] In winter, due to the cold weather, many people are habitually troubled by frostbite in winter. Chilblain is a localized, erythematous inflammatory lesion caused by exposure to a sub-zero cold environment. It is an abnormal inflammatory response to a cold, humid, and non-freezing environment. Histologically confirmed chilblain is a lymphocytic vasculitis. Chilblains usually manifest as single or multiple swollen bright red or dark red macules, papules or nodules, and blisters and ulcers can be seen in severe cases. Usually accompanied by itching or burning sensation, frostbite is prone to relapse, which is related to chronic vasculitis of local skin and decreased skin resistance after the disease. [0003] The medicine for the treatment of chilblain at present has western medicine, traditional Chinese medicine, is in the majorit...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/06A61P17/02
Inventor 周先礼肖峰郭璐黄帅单连海
Owner SOUTHWEST JIAOTONG UNIV
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