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Method for preparing ibuprofen inflatable cotton candy

A technology for inflating marshmallows and glucose, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of low oral bioavailability, poor patient compliance, and irritation of the stomach wall, etc. Achieve the effect of masking the taste of the drug, enhancing the sweetness, and preventing irritation of the stomach wall

Active Publication Date: 2014-08-06
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing ibuprofen aerated marshmallows in order to solve the problems of low oral bioavailability, bad mouthfeel, irritation of the stomach wall and poor patient compliance in existing ibuprofen medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0023] Specific embodiment one: the preparation method of a kind of ibuprofen aerated marshmallow of the present embodiment is to carry out according to the following steps:

[0024] One, sieving: take the ibuprofen crude drug, pass through a 200-mesh sieve; corn starch, pass through a 80-mesh sieve, and take the part under the sieve for later use;

[0025] 2. Weighing: Weigh 100-150 parts of ibuprofen raw material drug powder, 100-150 parts of starch, 600-900 parts of granulated sugar, 400-600 parts of glucose, 100 parts ~300 parts of gelatin powder, 1~3 parts of sodium alginate, 1~3 parts of stevioside, 1~3 parts of lemon essence, 6~8 parts of citric acid, 10~15 parts of table salt, 100~ 400 parts of water, 1 to 3 parts of sorbitol and 0.05 to 0.08 parts of tartrazine;

[0026] 3. Sol: Add the gelatin powder and sodium alginate weighed in step 2 into water at 65°C to 75°C and stir for 10 to 30 minutes to obtain a gelatin mixed solution; put the gelatin mixed solution in a v...

specific Embodiment approach 2

[0038]Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that in step 2, 100-120 parts of ibuprofen crude drug powder, 100-120 parts of cornstarch, 600-900 parts of Sugar, 500-600 parts of glucose, 100-200 parts of gelatin powder, 1-2 parts of sodium alginate, 1-2 parts of stevioside, 1-2 parts of lemon essence, 6-7 parts of citric acid , 10-12 parts of table salt, 200-300 parts of water, 1-2 parts of sorbitol and 0.05-0.07 parts of tartrazine. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0039] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: described in step two, weigh 100~110 parts of ibuprofen crude drug powder, 100~110 parts of cornstarch, 700~900 parts sugar, 550-600 parts of glucose, 110-200 parts of gelatin powder, 1-2 parts of sodium alginate, 1-2 parts of stevioside, 1-2 parts of lemon essence, 6.5-7.5 parts of lemon acid, 10-11 parts of salt, 150-300 parts of water, 1-2 parts of sorbitol, and 0.05-0.07 parts of tartrazine. Others are the same as in the first or second embodiment.

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PUM

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Abstract

The invention discloses a method for preparing an ibuprofen inflatable cotton candy and relates to the method for preparing the ibuprofen inflatable cotton candy, and the method can be used for solving the problems that the existing preparations such as ibuprofen granules, tablets and capsules are inconvenient to take, a common preparation is slow in effect taking, and inpatient children are poor in medication compliance. The method for preparing the ibuprofen inflatable cotton candy comprises the following steps: sieving raw and auxiliary materials; 2, weighing raw and auxiliary materials; 3, dissolving sol; 4, preparing a rubber block; 5, sugaring off; 6, mixing and inflating; 7, drying starch; 8, molding; 9, drying; 10, sieving and purifying; 11, choosing and packaging. The prepared ibuprofen inflatable cotton candy is good in mouthfeeel, quick in effect taking, high in oral bioavailability, good in compliance and applicable to industrial production, children are willing to take, and modern food and drug production equipment is adopted. The method disclosed by the invention is applied to the field of preparation of anti-inflammatory drugs, antalgic drugs and antipyretic drugs.

Description

technical field [0001] The invention relates to a preparation method of ibuprofen inflated marshmallow, which is used for anti-inflammation, analgesia and antipyretic medicine for colds. Background technique [0002] Because ibuprofen has anti-inflammatory, analgesic and antipyretic functions, it is used to relieve mild to moderate pain such as headache, joint pain, migraine, toothache, muscle pain, neuralgia, dysmenorrhea, etc. It is also used for common cold or epidemic Fever caused by common cold has a wide range of clinical application value. Because the preparation of ibuprofen's existing preparations is mostly made into granules, tablets, and capsules, the dosage form absorbs slowly and has low bioavailability; Taken by children; the preparation of suspensions and syrups is not convenient for transportation and use; and oral ibuprofen stimulates the stomach wall and causes discomfort. The patient compliance of ibuprofen injection is poor; therefore, the existing prep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/192A61K47/26A61K47/42A61K47/36A61P29/00
Inventor 刘景国柳松林钮旭升裴福成郑玥李文军肇静静尹涛李殿明王英新
Owner 哈药集团中药有限公司
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