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Medicine for preventing and treating acute radiation pneumonitis

A technology of radiation pneumonitis and drugs, which is applied in the field of biopharmaceuticals, can solve the problems such as no proanthocyanidin acute radiation pneumonitis research reports, and achieve the effect of improving inflammatory cell infiltration, good prevention and treatment effect

Inactive Publication Date: 2014-07-23
张维芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there are also patent applications related to the use of proanthocyanidins for medical purposes, for example, patent CN200510042958.8 for the new use of drugs for the preparation and treatment of colitis, patent CN200910154161.5 for the use of antidepressants and patent CN201210502442.7 for the preparation and treatment of colitis The application of diabetes drugs, but there is no research report on the use of proanthocyanidins in the treatment of acute radiation pneumonitis

Method used

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  • Medicine for preventing and treating acute radiation pneumonitis
  • Medicine for preventing and treating acute radiation pneumonitis
  • Medicine for preventing and treating acute radiation pneumonitis

Examples

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Embodiment

[0023] 1. Experimental method

[0024] 1.1 Grouping 64 healthy male SD rats, weighing (200±20) g, provided by the Animal Research Center of Weifang Medical College, were raised in an SPF rat breeding room, and caged for 7 days before the test to adapt to the environment. One week before irradiation, 64 SD male rats were randomly divided into blank control group, model group, proanthocyanidin (treatment) group and dexamethasone combined with cephalexin western medicine (positive control) group, with 16 rats in each group.

[0025] 1.2 Drug preparation: Accurately weigh an appropriate amount of proanthocyanidins and add them to sterile physiological saline to dissolve, stir evenly, and obtain a proanthocyanidin solution with a concentration of 2.5-3.75mg / ml. Ready to use now, keep away from light. The proanthocyanidin group began to inhale proanthocyanidin through the lungs on the first day after irradiation. Positive control drug: dexamethasone combined with cephalexin, dexam...

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Abstract

The invention discloses a medicine for preventing and treating acute radiation pneumonitis; the effective component of the medicine is procyanidine. The medicine is a procyanidine solution with the concentration of 2.5-3.75mg / ml; the procyanidine solution comprises procyanidine with the purity of 95-99% and a sterile saline solution; the delivery manner of the medicine is aerosol inhalation. The medicine disclosed by the invention has a good prevention and treatment effect to acute radiation pneumonitis and is a plant raw material medicine with a prospect, namely, the procyanidine can be used for preventing and treating acute radiation pneumonitis. Aerosol inhalation of procyanidine can effectively implement targeted drug delivery of lung, and further can avoid the first pass effect, reduce the use level of the medicine and alleviate or avoid adverse drug reactions while directly reaching the site of action, so that the purpose of preventing or even treating acute radiation pneumonitis is achieved.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, in particular to a medicine for preventing and treating acute radiation pneumonitis. Background technique [0002] Radiation pneumonitis is an acute spontaneous immune-like reaction mediated by inflammatory factors after part of the lung tissue receives a certain dose of ionizing radiation during radiotherapy in patients with lung cancer, esophageal cancer and other thoracic malignant tumors. It is an important complication after radiotherapy. . The lung is a moderately radiation-sensitive organ. Radiation therapy can cause lung damage to varying degrees in the lung tissue near the tumor because the radiation dose received exceeds the threshold for biological effects. [0003] As radiation pneumonitis continues to carry out radiotherapy, the patient's white blood cells and red blood cells have varying degrees of hemotoxicity, fatigue, nausea, diarrhea, and hair loss. Symptoms of acute radiatio...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P11/00
Inventor 张维芬冯占芹黄雪萍郑增娟
Owner 张维芬
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