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A kind of triamcinolone acetonide econazole cream and preparation method thereof

The technology of deeconazole cream and econazole nitrate is applied in the directions of anti-inflammatory agent, antifungal agent, ointment delivery, etc., can solve problems such as low solubility, drug precipitation, etc., and achieves simple preparation process and fast transdermal absorption. , the effect of high stability

Active Publication Date: 2015-12-09
江苏晨牌邦德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the solubility of triamcinolone acetonide and econazole nitrate in water is low. When preparing cream, if the drug cannot be dissolved in the oil phase or the water phase, drug precipitation is prone to occur.

Method used

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  • A kind of triamcinolone acetonide econazole cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Triamcinolone Acetonide 15g

[0035] Econazole Nitrate 150g

[0036] Isopropyl myristate 1.6kg

[0037] Macrogol glyceride laurate 3.3kg

[0038] Polyethylene glycol 4002.0kg

[0039] 5% hydroxypropyl cellulose aqueous solution 7.8kg

[0040] Preparation Process:

[0041] (1) Prescription quantity Dissolve triamcinolone acetonide and econazole nitrate in isopropyl myristate, then add macrogol glyceride laurate and polyethylene glycol 400 and stir evenly as the oil phase;

[0042] (2) Add the oil phase to a 5% aqueous solution of hydroxypropyl cellulose, and stir evenly to obtain a cream.

Embodiment 2

[0044] Triamcinolone Acetonide 15g

[0045] Econazole Nitrate 150g

[0046] Isopropyl myristate 4.9kg

[0047] Macrogol glyceride laurate 5.0kg

[0048] Polyethylene glycol 4001.0kg

[0049] 15% hydroxypropyl cellulose aqueous solution 3.9kg

[0050] Preparation Process:

[0051] (1) Prescription quantity Dissolve triamcinolone acetonide and econazole nitrate in isopropyl myristate, then add macrogol glyceride laurate and polyethylene glycol 400 and stir evenly as the oil phase;

[0052] (2) Add the oil phase to a 5% aqueous solution of hydroxypropyl cellulose, and stir evenly to obtain a cream.

Embodiment 3

[0054] Triamcinolone Acetonide 15g

[0055] Econazole Nitrate 150g

[0056] Isopropyl myristate 3.3kg

[0057] Macrogol glyceride laurate 4.9kg

[0058] Polyethylene glycol 4002.0kg

[0059] 10% hydroxypropyl cellulose aqueous solution 4.5kg

[0060] Preparation Process:

[0061] (1) Prescription quantity Dissolve triamcinolone acetonide and econazole nitrate in isopropyl myristate, then add macrogol glyceride laurate and polyethylene glycol 400 and stir evenly as the oil phase;

[0062] (2) Add the oil phase to a 5% aqueous solution of hydroxypropyl cellulose, and stir evenly to obtain a cream.

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Abstract

The invention discloses triamcinolone acetonide and econazole cream and a preparation method thereof. The cream is prepared by uniformly mixing a water phase and an oil phase, wherein the water phase is a hydroxy propyl cellulose water solution and the oil phase is prepared by virtue of the following steps: dissolving triamcinolone acetonide and econazole in isopropyl myristate, then adding dodecylicpolyethylene glycol glyceride laurate and polyethylene glycol 400 and uniformly stirring. Compared with the prior art, the medicament disclosed by the invention exists in the cream in a nanometer form, and is high in stability, rapid in transdermal absorption, simple in preparation process, free of use of complicated emulsion preparation equipment and suitable for the requirements of large-scale production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a triamcinolone acetonide-econazole compound preparation for external use, in particular to a triamcinolone acetonide-econazole cream and a preparation method thereof. Background technique [0002] Dermatomycosis is the abbreviation of a large class of skin diseases caused by fungi that infect the skin, mucous membranes and adnexa. This disease belongs to common disease, frequently-occurring disease, and the crowd prevalence rate can be as high as more than 20% in hot and humid areas. There are many kinds of pathogenic bacteria that cause skin fungal infections. For heterosexual antigens, the body often produces more obvious allergic reactions to pathogenic fungi that invade the skin. Clinically, it can be manifested as eczema dermatitis-like appearance, itching, ringworm rash, and severe secondary bacterial infection. [0003] Triamcinolone acet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K9/06A61P31/10A61P29/00A61P17/04A61P37/08A61K31/4174
Inventor 王勤学李宁宁高玉萍
Owner 江苏晨牌邦德药业有限公司
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