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A self-emulsifying drug delivery system of coenzyme q10 with high absorption rate and its preparation method and application

A technology of self-emulsification and coenzyme, applied in the field of medicine, can solve the problems affecting product quality and actual use effect, low content of coenzyme Q, etc., achieve good stability at room temperature and freeze-thaw, high dissolution rate, and improve motor function.

Inactive Publication Date: 2015-08-26
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

due to coenzyme Q 10 The isoprene structure of isoprene is extremely unstable, and it is easily oxidized and decomposed by oxygen and light in the air. It is decomposed more rapidly when heated or encountered with metal ions, which often leads to coenzyme Q in related products. 10 The content is low, which affects the quality and actual use effect of the product

Method used

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  • A self-emulsifying drug delivery system of coenzyme q10 with high absorption rate and its preparation method and application
  • A self-emulsifying drug delivery system of coenzyme q10 with high absorption rate and its preparation method and application
  • A self-emulsifying drug delivery system of coenzyme q10 with high absorption rate and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A coenzyme Q10 self-emulsifying drug delivery system with high absorption rate, its composition and parts by weight are as follows:

[0032]

[0033] Coenzyme Q with high absorption rate above 10 The preparation method of self-emulsifying drug release system, the steps are as follows:

[0034] Weigh the coenzyme Q according to the above weight percentage 10 Coenzyme Q 10 Self-emulsifying drug release system (6%, g / mL).

Embodiment 2

[0036] A Highly Absorbable Coenzyme Q 10 Self-emulsifying drug delivery system, its composition and parts by weight are as follows:

[0037]

[0038] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a self-emulsifying drug release system of coenzyme Q10 with high absorptivity. The self-emulsifying drug release system comprises the following components in parts by weight: 6 parts of coenzyme Q10, 26-30 parts of coconut oil, 51-55 parts of bitterness decanoic acid polyethylene glycol (peg) glyceride, and 11-15 parts of polyethylene glycol-400. The self-emulsifying drug release system is taken as a carrier, the in vivo absorptivity of the coenzyme Q10 with low bioavailability and difficult to dissolve in water is significantly improved, and the self-emulsifying drug release system can be used for preparing a water dispersible coenzyme Q10 health-care product preparation or being filled into a soft capsule, and can be widely applied to development of fat soluble dietary supplements.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a self-emulsifying drug delivery system, in particular to a method for improving coenzyme Q 10 A self-emulsifying drug delivery system with equal absorption rates for fat-soluble dietary supplements. Background technique [0002] coenzyme Q 10 (CoQ 10 ), also known as ubiquinone, is a fat-soluble quinone compound that widely exists in animals and plants. It combines with the inner membrane of mitochondria and plays an important role in the electron transfer of the respiratory chain of human cells. Its structure is similar to that of vitamin K. It is a yellow or orange-yellow crystalline powder at room temperature. It is sensitive to light and heat and is easily soluble in ethanol and oil-phase solvents. due to coenzyme Q 10 The isoprene structure of isoprene is extremely unstable, and it is easily oxidized and decomposed by oxygen and light in the air. It is decomposed more rapidl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C41/46A23L33/00
CPCA23L33/10A23L33/115A23V2002/00A23V2200/30A23V2250/18A23V2250/30
Inventor 张泽生余悦张颖王浩
Owner TIANJIN UNIV OF SCI & TECH
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