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Application of germanium-based graphene in osteogenesis promotion

A graphene and germanium-based technology, applied in the fields of graphene, bone diseases, carbon active ingredients, etc., can solve the problems of no discovery of germanium-based graphene, curative effect on tumors, and decline of germanium ion activity, so as to improve osteogenic performance. and the effect of use, the effect of promoting the expression of alkaline phosphatase, and the effect of promoting growth

Inactive Publication Date: 2014-05-28
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The normal human body does not lack such trace elements, but under the environment of modern industrial civilization, the human body has been chemically polluted for a long time, which makes the activity of germanium ions show signs of decline. Appropriate supplementation of this trace element is conducive to the improvement of body functions. Healthy, and germanium may have curative effect on tumors
However, at present, germanium-based graphene has not been found to have an osteogenesis-promoting application.

Method used

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  • Application of germanium-based graphene in osteogenesis promotion
  • Application of germanium-based graphene in osteogenesis promotion
  • Application of germanium-based graphene in osteogenesis promotion

Examples

Experimental program
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Embodiment 1

[0031] The preparation of embodiment 1 germanium-based graphene

[0032] In this embodiment, chemical vapor deposition (CVD) is used to prepare graphene on Ge, and the process flow is as follows:

[0033] A germanium layer is provided, the germanium layer is placed in a growth chamber, the germanium layer is heated to a preset temperature, and hydrogen and carbon sources are introduced into the growth chamber to grow graphene on the germanium layer, to obtain Germanium-based graphene.

[0034] In this embodiment, the growth chamber is described by taking a tube furnace as an example, in which the size of the germanium layer is 10 mm x 10 mm x 175 microns, the growth temperature is 800-910 °C, the flow rate of hydrogen gas is 2-100 sccm, and the carbon The source flow rate is 0.01-50 sccm, and the graphene growth time is 1-200 min. The carbon source can be CH 4 , C 2 h 2 , C 2 h 4 Or CO, etc., or a solid carbon source. In this embodiment, the preparation conditions of t...

Embodiment 2

[0039] The characterization of embodiment 2 germanium-based graphene

[0040] In this example, Raman was used to characterize the germanium-based graphene prepared in Example 1, and the light transmittance of the graphene on it was tested.

[0041] figure 2 Raman patterns of germanium-based graphene (G / Ge) prepared for germanium (Ge) and two growth temperatures are shown, where the D peak represents the defect of graphene on Ge. Depend on figure 2 It can be seen that the D peak of germanium-based graphene grown at 910°C (G / Ge910°C) is lower than that of germanium-based graphene grown at 890°C (G / Ge890°C), indicating that the higher the growth temperature, the higher the quality of graphene on germanium. the better.

[0042] image 3 It shows the light transmittance of graphene prepared at different temperatures, among which the light transmittance of graphene grown at 910°C for visible light with a wavelength of 550nm is 97.50%, and the light transmittance of graphene gr...

Embodiment 3

[0044] The preparation of germanium-based graphene on embodiment 3 titanium

[0045] Titanium and titanium alloy artificial bones and joints have excellent corrosion resistance and little biological reaction when used in the human body, so they are ideal human implants. Relevant research and a large number of clinical treatment examples from various countries in the world have recognized titanium and titanium alloys as the most ideal metal materials for human implants so far, and are listed as rising after stainless steel and cobalt-based alloys by the medical and surgical industry third-generation metals.

[0046] In this embodiment, a layer of germanium is sputtered on the surface of the titanium metal, then the titanium metal with the germanium layer formed on the surface is placed in the growth chamber and heated to a preset temperature, and then hydrogen gas and A carbon source is used to grow graphene on the germanium layer to obtain germanium-based graphene on titanium, ...

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Abstract

The invention provides application of germanium-based graphene in osteogenesis promotion. Germanium-based graphene can obviously promote the early alkaline phosphatase expression and late osteocalcin expression of bone narrow mesenchymal stem cells, and has the capability of obviously promoting the osteogenic differentiation of bone narrow mesenchymal stem cells; germanium-based graphene can be loaded on the surface of an implant with hard tissue, and then the implant can be implanted into a human body or animal body, so as to promote osteogenesis, improve the applying effect, promote osseointegration between the implant and bones, and promote the formation of new bones. Also, germanium-based graphene can be used as an osteogenesis promotion component to prepare drugs for treating bone defects or osteoporosis. In addition, germanium in germanium-based graphene has an anti-cancer anti-aging health-care function.

Description

technical field [0001] The invention designs a new application of germanium-based graphene, in particular relates to an osteogenesis-promoting application of germanium-based graphene. Background technique [0002] In recent years, stem cells have gradually become a hot spot in the research of bone tissue engineering. The use of bone tissue engineering can not only repair large areas of bone defects, but also can be shaped and prepared in large quantities on demand. It is an ideal method for wound repair. Stem cells are undifferentiated primitive cells with the potential of self-renewal and differentiation. Once physiologically required, these primitive cells can produce differentiated mature cells according to the developmental pathway, and have great medical application prospects. Depending on where they exist, stem cells can be divided into the following two types: embryonic stem cells and adult stem cells. Under certain conditions, embryonic stem cells can differentiate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0775C12N5/077C01B31/04A61K33/44A61P19/08A61P19/10A61L27/30A61L27/06C01B32/186
Inventor 狄增峰王刚李金华刘宣勇陈达郭庆磊叶林张苗丁古巧谢晓明
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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