Novel strontium-doped gamma-polyglutamic acid/tricalcium phosphate composite material and preparation method thereof

Abstract

The invention provides a novel strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite material and a preparation method thereof. The method comprises the steps of preparing calcium ion, phosphonium ion and strontium ion solutions, adding gamma-polyglutamic acid to the calcium ion and strontium ion solutions for reacting at first, and then dropwise adding the phosphonium ion solution, and carrying out stirring, ageing, setting and freeze-drying to obtain the composite material. The preparation method is a new method of adding the biopolymer gamma-polyglutamic acid and the strontium element to tricalcium phosphate to prepare the strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite material through an in-situ polymerization wet process. The strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite nano-material prepared by the method is a white powder; the compressive strength of the composite material ranges from 71Mpa to 105Mpa and the bending strength of the composite material ranges from 65 to 98Mpa, and the mechanical properties of the composite material are obviously improved. The composite material is capable of ensuring that calcium ions and phosphonium ions in tricalcium phosphate and strontium ions are released from the gamma-polyglutamic acid continuously, steadily and slowly in the bone repair process, and is also capable of improving the bone bonding ability of the tricalcium phosphate composite material and promoting repair of bone defect.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and in particular relates to a novel strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite material and a preparation method thereof. Background technique [0002] Tricalcium phosphate (TCP) is an artificial bone graft material developed in recent years. It is mainly composed of calcium and phosphorus ions, and its chemical formula is Ca 3 (PO 4 ) 2 , similar to the inorganic components in bone, including high-temperature α-phase and low-temperature β-phase. TCP has been used as a bone repair material for more than 30 years. However, when tricalcium phosphate is used alone as a bone repair material, there are various defects, which limit its clinical application. The main disadvantages of tricalcium phosphate are: (1) It has poor toughness, high brittleness, low flexural strength, and cannot bear weight, so it can only be used for non-load-bearing bone defects; (2) Lack of inducti...

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Problems solved by technology

However, when tricalcium phosphate is used alone as a bone repair material, there are various defects, which limit its clinical application.

The main disadvantages of tricalcium phosphate are: (1) It has poor toughness, high brittleness, low flexural strength, and cannot bear weight, so it can only be used for non-load-bearing bone defects; (2) Lack of inductive activity, the material can only It can grow bone tissue by osteoconduction, the amount of bone growth is small, it takes a long time, and the depth of bone ingrowth is limited, so it is not suitable for repairing long bone defects; (3) The degradation rate is difficult to control and cannot match the growth rate of new bone

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