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High-purity grape seed extract tablet and preparation method thereof

A grape seed, high-purity technology, applied in food preparation, food ingredients as solubility improvers, anti-toxic agents, etc., can solve the problems of large amount of excipients, hard tablets, slow disintegration speed, etc., to achieve strong anti-aging ability, High bioavailability and good tablet stability

Active Publication Date: 2014-03-05
HEXI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent solves the problem that the grape seed extract is difficult to carry, the prepared grape seed tablet contains a large amount of excipients, the grape seed extract is unevenly dispersed, the content uniformity is poor, and the tablet is too hard and the disintegration speed is slow , not conducive to disintegration, affecting the efficacy of the tablet, slow onset, poor stability, and thus affecting the bioavailability of the tablet

Method used

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  • High-purity grape seed extract tablet and preparation method thereof
  • High-purity grape seed extract tablet and preparation method thereof
  • High-purity grape seed extract tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] raw material:

[0044]

[0045]

[0046] Preparation method:

[0047] a) Take the grape seed extract of the prescribed amount and pulverize it, pass through a 100-mesh sieve, and set aside;

[0048] b) Weigh maltodextrin and xylitol monooleate in the prescribed amount, grind them, add the grape seed extract in step a) while grinding, and continue grinding to obtain the ground product;

[0049] c) Grinding said parts by weight of starch, 55% of said parts by weight of microcrystalline cellulose, and said parts by weight of carrageenan to obtain secondary grindings;

[0050] d) mixing the main grind and the auxiliary grind evenly, and granulating to obtain coarse particles;

[0051] e) passing the coarse particles through a 100-mesh sieve to obtain fine particles;

[0052] f) Mix the silicon dioxide, magnesium stearate and the remaining part of microcrystalline cellulose with the fine particles uniformly by weight, and press into tablets to obtain the high-purity...

Embodiment 2

[0054] raw material:

[0055]

[0056] Preparation method:

[0057] a) Weigh the grape seed extract of the prescribed amount and pulverize it, pass through an 80-mesh sieve, and set aside;

[0058] b) Weigh maltodextrin and xylitol anhydride monooleate of prescription amount, grind, add step while grinding

[0059] The grape seed extract in step a) is continuously ground to obtain the ground product;

[0060] c) Grinding the starch and mannitol of the weight portion, 68% of the weight portion of sodium carboxymethyl starch, to obtain the secondary grinding;

[0061] d) mixing the main grind and the auxiliary grind evenly, and granulating to obtain coarse particles;

[0062] e) passing the coarse particles through a 100-mesh sieve to obtain fine particles;

[0063] f) Mix the polyethylene glycol 400 in the weight part and the sodium carboxymethyl starch in the remaining part with the fine particles uniformly, and press into tablets to obtain the high-purity grape seed ex...

Embodiment 3

[0065] raw material:

[0066]

[0067] Preparation method:

[0068] a) Take the grape seed extract of the prescribed amount and pulverize it, pass through a 100-mesh sieve, and set aside;

[0069]b) Weigh the prescribed amount of maltodextrin, grind it, add the grape seed extract in step a) while grinding, and continue grinding to obtain the ground product;

[0070] c) Grinding the starch and 65% of the parts by weight of the microcrystalline cellulose to obtain secondary grindings;

[0071] d) mixing the main grind and the auxiliary grind evenly, and granulating to obtain coarse particles;

[0072] e) passing the coarse particles through a 120-mesh sieve to obtain fine particles;

[0073] f) Mix the silicon dioxide, magnesium stearate and the remaining part of microcrystalline cellulose with the fine particles uniformly by weight, and press into tablets to obtain the high-purity grape seed extract tablet of the present invention.

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Abstract

The invention discloses a high-purity grape seed extract tablet which comprises the following components in parts by weight: 700-1100 parts of grape seed extract, 30-70 parts of maltodextrin, 2-18 parts of filler, 5-35 parts of disintegrating agent, and 5-35 parts of lubricant, wherein the filler is starch, or a combination of starch and one or more of lactose, mannitol, xylitol and sorbitol; the disintegrating agent is one or more of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, povidone, and croscarmellose sodium; the lubricant is one or more of magnesium stearate, hydrogenated vegetable oil, a stearic acid, silica, superfine silica powder, polyethylene glycol 400, and magnesium dodecyl sulfate. The high-purity grape seed extract tablet disclosed by the invention is small in amount of auxiliary materials, the grape seed extract is uniformly dispersed, the tablet is good in disintegration property and becomes effective slowly, and the tablet is good in stability, high in bioavailability, and strong in anti-aging ability.

Description

technical field [0001] The invention belongs to the field of health care products with active ingredients of natural products, and in particular relates to a high-purity grape seed extract tablet prepared by using grape seed extract as a raw material and a preparation method thereof. technical background [0002] With the improvement of living standards, people pay more and more attention to their own health and appearance, and free radicals are intermediate metabolites produced by biochemical reactions in human tissues that damage health and accelerate aging. If there are too many, it needs to be suppressed and eliminated, otherwise it will damage human health, not only will produce various diseases, but also accelerate the aging of the body. Studies have shown that grape seed extract has super strong antioxidant capacity, which is 50 times that of vitamin E and 20 times that of vitamin C. It can prevent arteriosclerosis and delay aging. It is known as the skin vitamin; the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A61K36/87A61K9/20A61K47/36A61K47/34A61K47/38A61K47/04A61K47/12A61P39/06A23L33/00
CPCA23L33/10A23L33/105A23P10/28A23V2002/00A23V2200/302A23V2250/21166A23V2250/5114A23V2250/5118A23V2250/51084A23V2250/18A23V2250/161A23V2250/1628A23V2200/238A23V2200/20A23V2250/5036
Inventor 罗光宏杨生辉周文政张娇朱小琴
Owner HEXI UNIV
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