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Double in-situ synthesis method of temperature-responsive nano silver composite hydrogel

A composite hydrogel and temperature-responsive technology, which is applied in the field of biochemistry, can solve problems such as unstable structure of synthetic products, difficult regulation of synthetic methods, and uneven distribution of silver particles, so as to facilitate the release of medical drugs and facilitate disposal after disposal Effect of processing, temperature responsiveness enhancement

Active Publication Date: 2014-02-19
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are defects such as unstable structure of the synthesized product, uneven distribution of silver particles, refractory impurities, difficult control of the synthesis method, and high radiation intensity.

Method used

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  • Double in-situ synthesis method of temperature-responsive nano silver composite hydrogel
  • Double in-situ synthesis method of temperature-responsive nano silver composite hydrogel
  • Double in-situ synthesis method of temperature-responsive nano silver composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The specific operation steps of the dual in-situ synthesis method of temperature-responsive nano-silver composite hydrogel are as follows:

[0036] 1) Measure 808ul of dimethylaminoethyl methacrylate, weigh 1.0g of 2-acrylamido-2-methylpropanesulfonic acid, 0.0088g of N, N'-methylenebisacrylamide, and measure Take 346ul of polyethylene glycol 400 and 10ml of distilled water into the four-necked flask in turn, and dissolve evenly;

[0037] 2) Fix the thermometer, dropping funnel, nitrogen tube, and exhaust pipe on the four-necked flask, and then fix the four-necked flask in a heating mantle at 30°C;

[0038] 3) One port of the four-neck flask was vented with nitrogen, and the other port was exhausted for 15 minutes to ensure that the air was completely removed, then the exhaust pipe was sealed to continue nitrogen protection;

[0039] 4) Add 0.8154g of silver nitrate and 5ml of distilled water into the dropping funnel;

[0040] 5) Use UV-A340 ultraviolet light to irra...

Embodiment 2

[0051] The specific operation steps of the dual in situ synthesis method of the temperature-responsive composite hydrogel are as follows:

[0052] 1) Measure 808ul of dimethylaminoethyl methacrylate, weigh 1.0g of 2-acrylamido-2-methylpropanesulfonic acid, 0.0088g of N, N'-methylenebisacrylamide, and measure Take 346ul of polyethylene glycol 400 and 15ml of distilled water into the three-necked flask in sequence, and dissolve evenly;

[0053] 2) Fix the thermometer, nitrogen pipe and exhaust pipe on the three-necked flask, and then fix the three-necked flask in a heating mantle at 30°C;

[0054] 3) One port of the three-neck flask was vented with nitrogen, and the other port was exhausted for 15 minutes to ensure that the air was completely removed, and then the exhaust pipe was sealed to continue nitrogen protection;

[0055] Utilize UV-A340 ultraviolet light to irradiate the three-necked flask, and the technological condition of ultraviolet radiation is that the intensity i...

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Abstract

The invention relates to a double in-situ synthesis method of temperature-responsive nano silver composite hydrogel. By adopting an ultraviolet radiation method, under a condition without an initiator and a reducing agent, with dimethylaminoethyl methacrylate and 2-acrylamide-2-methylpropanesulfonic acid as monomers, N,N'-methylene bisacrylamide as a cross-linking agent, polyethylene glycol 400 as a pore forming agent, and silver nitrate as a metal source, and under a nitrogen atmosphere, the temperature-responsive nano Ag / P(DMAEMA-g-AMPS) composite hydrogel is synthesized. The prepared nano silver composite hydrogel has uniform dispersed nano silver particles and good chemical cross-linking stability, allows the swelling degree to be increased by 294.8 compared with that of pure water gel, and improves water absorbency and water retention of the hydrogel; the composite hydrogel allows temperature responsiveness to be enhanced, thereby being beneficial for medical drug release and other applications; and the composite hydrogel allows the thermal decomposition temperature to be decreased by 78 DEG C compared with that of pure hydrogel, thereby being beneficial for polymer waste post-processing.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, and in particular relates to a dual in-situ synthesis method of temperature-responsive nano-silver composite hydrogel. Background technique [0002] Dimethylaminoethyl methacrylate is a typical temperature-sensitive monomer, and 2-acrylamido-2-methylpropanesulfonic acid is a hydrophilic monomer. Although the copolymerization of the two hydrogels improves the hydrogel The degree of swelling, but the response to temperature becomes poor. Nano-silver particles can coordinate with the oxygen atoms and nitrogen atoms of monomer amide groups, and the three-dimensional network polymer matrix provides network space for nano-silver particles. Silver as a cross-linking point can not only improve the swelling degree, but also improve Temperature responsiveness, so the synthesis of temperature-responsive nano-silver composite hydrogels is a promising material. However, due to the large specific surfac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/34C08F220/58C08F2/48C08K3/08
Inventor 邢宏龙洪戈曹小丽莫立鑫
Owner ANHUI UNIV OF SCI & TECH
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