Ultrafine powder piece of prepared rehmannia root, and preparation method and use thereof
A technology of ultra-fine powder and powder decoction pieces, which is applied in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of reducing clinical use, saving medicinal resources, and fast speed
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Embodiment 1
[0045] 1 Material pretreatment
[0046] 1.1 Material drying
[0047] Dry rehmannia glutinosa with vacuum microwave drying equipment, the microwave parameters are vacuum degree -0.70~-0.95MPa, microwave power 1~5KW, temperature 40~60°C, dry until the water content is below 5.5% by weight, and let it cool.
[0048] 1.2 Material crushing
[0049] The dried rehmannia glutinosa is pulverized into fine powder with a Cuting mill, sieved, and set aside.
[0050] 1.3 Initial homogenate
[0051] 1.3.1 Investigation of solid-liquid ratio
[0052] Mix Shudi fine powder with water at a weight ratio of 1:4, 1:6, 1:8, 1:10, and 1:12, adjust the speed of the high-shear emulsifier to "F" (25,000rpm), and mix well Slurry for 5 minutes, observe the state of the slurry and measure the particle size distribution to ensure that the particle size of the material after the initial homogenization is less than 50 μm. As a result, when the speed of the homogenizer is selected at a higher level "F", ...
Embodiment 2
[0081] Embodiment 2 and the comparison of dissolution rate and leaching rate of traditional decoction pieces
[0082] 1 Determination of the dissolution rate of verbascoside
[0083] 1.1 Method
[0084] According to the liquid phase condition method under the first part of the "Chinese Pharmacopoeia" 2010 edition, octadecylsilane bonded silica gel is used as filler; acetonitrile-0.1% acetic acid solution (16:84) is used as mobile phase; detection wavelength 334nm. The number of theoretical plates should not be less than 5000 based on the peak of verbascoside.
[0085] 1.2 Preparation of reference solution
[0086] Accurately weigh an appropriate amount of verbascoside reference substance, accurately weigh it, add mobile phase to make a solution containing 10 μg per 1 ml, and obtain it.
[0087] 1.3 Sample extraction
[0088]Precisely weigh about 2.5 g of common decoction pieces of Rehmannia glutinosa (content of verbascoside 0.026% by weight) and superfine powder decoct...
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