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Wettable sulfamethoxazole trimethoprim powder and preparation method thereof

A technology of sulfamethoprim powder and wetness, which is applied in the field of wettable sulfamethoprim powder and its preparation, and can solve problems such as difficulty in mixing uniformly, little or no curative effect, and poisoning by animal drug intake.

Active Publication Date: 2014-01-29
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this dosage form can play a therapeutic role in animals in production, there are still some limitations in application
When the premix is ​​used, it can only be administered through feed. Feed administration requires that the drug and feed be mixed evenly, but it is difficult to mix evenly in actual operation, which may easily cause animal poisoning due to excessive drug intake or too little drug intake without curative effect.

Method used

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  • Wettable sulfamethoxazole trimethoprim powder and preparation method thereof
  • Wettable sulfamethoxazole trimethoprim powder and preparation method thereof
  • Wettable sulfamethoxazole trimethoprim powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Embodiment 1 The formula screening of wettable trimethoprim powder of the present invention

[0092] The screening formula is shown in formula 1 to formula 7 in Table 1:

[0093] The screening formula of table 1 wettable trimethoprim powder of the present invention

[0094]

[0095]

[0096] Weigh the raw materials in each weight percentage of formula 1 to formula 7 in Table 1, mix them uniformly, grind them to 625 mesh ultrafine powder, pack them, and obtain the wettable disulfonamide prepared from formula 1 to formula 7 Oxicillin powder.

[0097] The wettable trimethoprim powder prepared from formula 1 to formula 7 was evaluated for dispersion quality, sedimentation volume ratio quality evaluation and palatability quality evaluation.

[0098] Dispersion quality evaluation: Take 1g of each wettable bisulmethoprim powder prepared according to formula 1 to formula 7 in Table 1, put them into 1000mL drinking water respectively, observe or stir and observe its disper...

Embodiment 2

[0114] Embodiment 2 Preparation of wettable trimethoprim powder of the present invention

[0115] formula:

[0116]

[0117] The above-mentioned raw materials are weighed, mixed evenly, crushed to a 625-mesh ultrafine powder, and packaged to obtain the wettable trimethoprim powder of the present invention.

Embodiment 3

[0118] Embodiment 3 Preparation of wettable trimethoprim powder of the present invention

[0119] formula:

[0120]

[0121]

[0122] The above raw materials are weighed, mixed evenly, crushed to 700-mesh ultrafine powder, and packaged to obtain the wettable trimethoprim powder of the present invention.

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Abstract

The invention relates to the technical field of veterinary medicine preparation, and particularly relates to wettable sulfamethoxazole trimethoprim powder and a preparation method thereof. The wettable sulfamethoxazole trimethoprim powder provided by the invention is added with potassium citrate, a suspending agent and a wetting agent on the basis of effective components of the original medicine; by reasonable medicine proportioning, the invention provides the wettable sulfamethoxazole trimethoprim powder which is easy to disperse evenly in water and convenient to take with water. Compared with commercially available sulfamethoxazole trimethoprim premix, the wettable sulfamethoxazole trimethoprim powder is good in therapeutic effect, convenient to use and small in toxic and side effects. The invention also provides the preparation method of the wettable sulfamethoxazole trimethoprim powder, and the preparation method is simple in technology, low in production cost and suitable to industrialized production.

Description

technical field [0001] The invention relates to the field of veterinary drug preparation, in particular to a wettable trimethoprim powder and a preparation method thereof. Background technique [0002] Trimethoprim is a compound preparation of Sulfadiazine (SD), Sulfamethoxazole (SMZ) and Trimethoprim (TMP). [0003] Sulfadiazine is also known as 2-p-aminobenzenesulfonamide pyrimidine, Diyajing, sulfapyridazine, sulfadiazine zinc, Daanjing, Xiaofadiyajing, and its chemical name is N-2-pyrimidinyl-4-aminobenzenesulfonamide , the molecular formula is C 10 h 10 N 4 o 2 S, with a molecular weight of 250.28 and a melting point of 252-258°C, is an odorless, tasteless, white or off-white crystal or powder that gradually darkens when exposed to light. SD is easily soluble in sodium hydroxide test solution or ammonia test solution, soluble in dilute hydrochloric acid, slightly soluble in ethanol or acetone, and almost insoluble in water. [0004] SD is easy to absorb when taken...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K9/14A61K47/38A61K47/04A61K47/10A61K33/12A61P33/02A61P31/04A61K31/505
Inventor 丁晓刚房春林李犹平杨海涵
Owner CHENGDU QIANKUN VETERINARY PHARMA
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