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Antibacterial and anti-tumor orthopedic implant material and preparation method thereof

An implant material and anti-tumor technology, applied in medical science, prosthesis, etc., can solve problems such as time-consuming, long-lasting, local recurrence, etc., to avoid the use of antibiotics, prevent adhesion and reproduction, and prevent recurrence and metastasis Effect

Inactive Publication Date: 2014-10-08
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The traditional treatment of bone and soft tissue tumors is extensive resection of tumors including normal tissues, tumor inactivation and reimplantation, and various artificial prosthesis replacements such as endoluminal catheterization, joint replacement, and various biological bone implants. Limb salvage treatment by transplantation and other methods, and in the process of bone tumor surgery, due to the particularity of the tumor site, such as joints and spine, a large number of blood vessels and nerves are often adhered, which will take a long time during the entire operation and easily lead to infection
At present, in order to avoid the infection caused by the initial stage of implantation, the method of drug control and wound disinfection in the later stage is mostly used. This method is complicated and cumbersome, and lasts for a long time. After the tumor is removed, local recurrence and systemic metastasis often occur.
[0003] Commonly used orthopedic implant materials include pure titanium, titanium alloy, stainless steel and other metal materials, as well as degradable polylactic acid, autologous bone, allogeneic bone, and xenograft bone, etc., but the surface properties of the materials cannot meet the anti-tumor and antibacterial requirements.

Method used

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  • Antibacterial and anti-tumor orthopedic implant material and preparation method thereof
  • Antibacterial and anti-tumor orthopedic implant material and preparation method thereof
  • Antibacterial and anti-tumor orthopedic implant material and preparation method thereof

Examples

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preparation example Construction

[0029] A preparation method for an antibacterial and antitumor orthopedic implant material, comprising the following steps:

[0030] 1) After the surface of the medical pure titanium sheet is polished with sandpaper, it is ultrasonically washed with ethanol and acetone for 25-35 minutes respectively, and then washed with HNO 3 Polish with HF mixture for 25-35 minutes, wash and dry;

[0031] 2) React the polished pure titanium with dopamine solution at 20-30°C for 10-14 hours to bind dopamine to the surface of the pure titanium sheet, then wash the dopamine-bound pure titanium sheet with PBS buffer solution, and blow it with liquid nitrogen. Dry, repeat this process 2 to 4 times, the obtained material is marked as DM-Ti;

[0032] 3) Under ultrasonic conditions, add heparin sodium solution dropwise into an equal volume of polylysine solution to form a suspension of polylysine-heparin sodium particles, and then put DM-Ti into the suspension The solution was reacted for 10-14 ho...

Embodiment 1

[0043] 1) Take 1cm 2 The medical pure titanium sheet was polished with 120-grit sandpaper, then ultrasonically washed with ethanol for 30 minutes, then ultrasonically washed with acetone for 30 minutes, and then placed in a solution containing 12.5 mg / mL HNO 3 and 12.5 mg / mL HF mixture for 30 minutes, washed with deionized water, and dried;

[0044] 2) Prepare a 0.2 mg / mL dopamine solution with Tris-HCl with pH 8.5 as solvent, place the polished titanium in the dopamine solution, react at room temperature for 12 hours, wash it with PBS buffer solution, and blow it with liquid nitrogen. Dry, repeat this process 3 times, the obtained material is marked as DM-Ti;

[0045]3) Using PBS buffer as a solvent, prepare 5 mg / mL sodium heparin solution and 0.5 mg / mL polylysine solution respectively, and add the heparin sodium solution dropwise to an equal volume of polylysine under ultrasonic conditions After the acid solution, continue to sonicate for 30s to form a suspension of polyly...

Embodiment 2

[0048] 1) Take 1cm 2 The medical pure titanium sheet was polished with 120-grit sandpaper, then ultrasonically washed with ethanol for 25 minutes, then ultrasonically washed with acetone for 25 minutes, and then placed in a solution containing 11 mg / mL HNO 3 and 11 mg / mL HF mixture for 35 minutes, washed with deionized water, and dried;

[0049] 2) Prepare a 0.1 mg / mL dopamine solution with Tris-HCl with pH 8.7 as solvent, place the polished titanium sheet in the dopamine solution, react at room temperature for 14 hours, wash with PBS buffer, and liquid nitrogen Blow dry, repeat this process 2 times, the obtained material is marked as DM-Ti;

[0050] 3) Using PBS buffer as a solvent, prepare 6 mg / mL sodium heparin solution and 0.6 mg / mL polylysine solution respectively, and add the heparin sodium solution dropwise to an equal volume of polylysine under ultrasonic conditions After the acid solution, continue to sonicate for 30s to form a suspension of polylysine-heparin sodiu...

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Abstract

The invention discloses an antibacterial and antitumor orthopedic implant material and a preparation method thereof. The implant material is a medical pure titanium sheet whose surface is modified with chitosan, methotrexate, heparin sodium, polylysine and dopamine . The present invention uses dopamine as a bridge to combine polylysine and heparin sodium particles on the surface of metal titanium. On the one hand, heparin acts as a good anticoagulant to improve the biocompatibility between the material and blood; Combined with chitosan and methotrexate which have antibacterial and antitumor effects. The present invention skillfully utilizes the physiological and biochemical characteristics of each drug to form an orderly, uniform and highly biocompatible antibacterial and antitumor coating on the titanium surface. The prepared implant material has good antibacterial and antitumor activity, which not only effectively prevents The adhesion and reproduction of bacteria can also effectively prevent the recurrence and metastasis of cancer.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an orthopedic implant material and a preparation method thereof, in particular to an antibacterial and anti-tumor orthopedic implant material and a preparation method thereof. Background technique [0002] The traditional treatment of bone and soft tissue tumors is extensive resection of tumors including normal tissues, tumor inactivation and reimplantation, and various artificial prosthesis replacements such as endoluminal catheterization, joint replacement, and various biological bone implants. Limb salvage treatment by transplantation and other methods, and in the process of bone tumor surgery, due to the particularity of the tumor site, such as joints and spine, a large number of blood vessels and nerves are often adhered, which will take a long time during the entire operation and easily lead to infection . At present, in order to avoid the infection caused by the initial ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/20A61L27/54A61L27/22
Inventor 李丽华张余李梅何鹏夏虹尹庆水郑冠
Owner GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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