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A polysulfone hollow fiber dialysis membrane and its manufacturing method

A hollow fiber and manufacturing method technology, applied in the field of hemodialysis, can solve the problems such as failure to solve the membrane anticoagulation and anti-protein adsorption capacity, high cost, time-consuming and the like, and achieve strong anticoagulation and anti-protein adsorption capacity, Avoid activation, high clearance effects

Active Publication Date: 2016-01-13
WEIHAI WEIGAO BLOOD PURIFICATION PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method effectively addresses membrane hydrophilicity, but fails to address membrane anticoagulant and antiprotein adsorption capabilities
In addition, during the manufacturing process of membrane modules, the membrane filaments must be dewatered. The traditional way of dewatering is to use alcohols with low volatility and strong hygroscopicity, such as using glycerol to replace the water in the membrane, but the subsequent alcohols Elution and drying of the replacement fluid is time-consuming, expensive, and carries carryover issues

Method used

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  • A polysulfone hollow fiber dialysis membrane and its manufacturing method
  • A polysulfone hollow fiber dialysis membrane and its manufacturing method

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Effect test

Embodiment 1

[0028] A polysulfone hollow fiber dialysis membrane, which is processed from the following raw materials in proportion by mass: 25 parts of polysulfone, 25 parts of biocompatible functional polymer, 10 parts of polyvinylpyrrolidone, and dimethylacetamide as the solvent (DMAc) 100 parts. Among them, the biocompatible functional polymer is prepared from diosgenin, polyethylene glycol, N-vinylpyrrolidone, and polysulfone through the following polymer chemical synthesis and graft modification methods: combining diosgenin with dihydroxy Linking fragments of terminal functional groups (such as methylene repeating units, vinyl chloride structural units, etc.) In 10 parts of dichloromethane, dissolve an excess of 5% to 10% acryloyl chloride in chloroform, and slowly add it dropwise to the diosgenin solution for condensation esterification, triethylamine is an organic base catalyst, at -20°C React at 0°C for 5 to 8 hours. , and then separated and purified by chromatographic column to...

Embodiment 2

[0032] A polysulfone hollow fiber dialysis membrane, which is processed from the following raw materials in proportion by mass: 5 parts of polysulfone, 50 parts of biocompatible functional polymer, 1 part of polyethylene glycol, and solvent dimethylacetamide (DMAc) 200 parts; wherein the biocompatible functional polymer is prepared from heparin, polyvinyl alcohol, polymethyl methacrylate and polysulfone through a polymer synthesis method and a graft modification method.

[0033] Its manufacturing method is as follows: select raw materials according to the ratio of parts; put the selected raw materials into a stirring tank, and stir at 80°C for 24 hours to form a homogeneous solution; introduce the homogeneous solution into the spinning tank, and vacuumize and defoam. It is extruded from a spinneret at 20°C, passed through a 1000mm dry spinning process, coagulated by a coagulation device, dried by a drying device, and finally collected by a winding device to obtain a finished pr...

Embodiment 3

[0035] A polysulfone hollow fiber dialysis membrane, which is processed from the following raw materials in proportion by mass: 40 parts of polysulfone, 1 part of biocompatible functional polymer, 20 parts of polyethylene glycol, and solvent dimethylacetamide (DMAc) 100 parts; wherein the biocompatible functional polymer is prepared from diosgenin, polymethyl methacrylate, polysaccharide and polysulfone through a polymer synthesis method and a graft modification method.

[0036] Its manufacturing method is as follows: select raw materials according to the ratio of parts; put the selected raw materials into a stirring tank, and stir at 120°C for 8 hours to form a homogeneous solution; introduce the homogeneous solution into the spinning tank, and vacuumize and defoam. It is extruded from a spinneret at 90°C, passed through a 100mm dry spinning process, coagulated by a coagulation device, dried by a drying device, and finally collected by a winding device to obtain a finished pro...

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Abstract

A polysulfone hollow fiber dialysis membrane and a manufacturing method thereof relate to the technical field of hemodialysis, and are processed from the following raw materials in proportions by mass: 5-40 parts of polysulfone, 1-50 parts of biocompatible functional polymer , 1-20 parts of pore-forming additives, 10-200 parts of solvent; wherein the biocompatible functional polymer is composed of at least one biocompatible material, at least one anticoagulant functional material and at least one anti-protein adsorption function The material is synthesized by polymer chemical synthesis method. The above materials are mixed and stirred to form a homogeneous solution, and then after vacuum degassing, it is extruded from the spinneret, and after a dry spinning process, it enters the multi-stage coagulation box and the multi-stage drying box in turn, and finally the coil collected around the device. The polysulfone hollow fiber dialysis membrane prepared by this method has the advantages of high mechanical strength and chemical stability, good biocompatibility without complement activation, and high clearance rate of small molecule solutes, and is widely used in the manufacture of low-cost, high-efficiency biocompatible good sex.

Description

technical field [0001] The invention relates to the technical field of hemodialysis, specifically a polysulfone hollow fiber dialysis membrane with high mechanical strength and chemical stability, good biocompatibility and superior performance and a manufacturing method thereof. Background technique [0002] In my country, nearly 4 million people suffer from acute kidney disease every year, and the number is still increasing year by year. The mortality rate of critically ill acute kidney injury is as high as 60.3%. At present, about 20% of patients with kidney disease are caused by acute kidney injury, and a considerable number of patients with acute kidney injury have renal failure (commonly known as "uremia") due to untimely treatment and need to receive blood for life. Dialysis treatment. At present, according to the current number of patients who need hemodialysis treatment in my country (300,000 people), it is estimated that each person needs about 150 dialysis sessio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/68B01D69/08B01D67/00A61M1/18
Inventor 牟倡骏何红星徐天成李敏
Owner WEIHAI WEIGAO BLOOD PURIFICATION PROD
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