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Good microencapsulation method for carotenoid

A carotenoid, a good technology, applied in the field of preparation of carotenoid granules or powder, can solve the problems of easy decomposition or isomerization, low carotenoid embedding rate, affecting the effective absorption of animals, etc., and achieves improved embedding rate, significant coloration, increased water dispersibility

Active Publication Date: 2013-09-11
肇庆巨元生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The disadvantage of the above method is that the temperature in the process conditions is high, and because carotenoids are extremely unstable at high temperatures, they are prone to decomposition or isomerization, which causes the loss of carotenoids and affects the effective absorption of animals.
In addition, the higher temperature also causes a waste of energy
Moreover, the embedding efficiency of the emulsion carotenoids prepared by these methods is low, the particle size is large, and the water dispersibility is poor.

Method used

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  • Good microencapsulation method for carotenoid
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  • Good microencapsulation method for carotenoid

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0037] A good microencapsulation method of carotenoids is carried out in the following steps:

[0038] 1. Completely dissolve 33g gelatin, 43.3g sucrose, 1.5g Vc palmitate, 0.2g EDTA, 0.5g tea saponin into 100.0g water to form a uniform water phase A, adjust the pH to 10.0-10.5 with 20% NaOH solution.

[0039] 2. Dissolve 18.0 g of canthaxanthin crystals, 3.0 g of ethoxyquin, and 0.5 g of VE oil in 360.0 g of dichloromethane, stir until completely dissolved, and obtain oil phase B.

[0040] 3. Under high stirring and high shear conditions, add oil phase B to water phase A, then emulsify at a stirring speed of 2900-18000rpm for 15 minutes, then raise the temperature to 50°C to remove the solvent and form a microemulsion. Wherein, the obtained microemulsion is a sub-nanometer microemulsion, its average particle size is 130-200nm, and the pH of the microemulsion is 9-10; high stirring and high shearing means: the shearing power is: 0.5-100Kw, The stirring speed is 2900-18000 rpm...

specific Embodiment 2

[0046] 1. Dissolve 33g of gelatin, 51.g of sucrose, 1.5g of Vc palmitate, 0.2g of EDTA, and 0.5g of tea saponin into 100.0g of water to form a uniform water phase. Adjust the pH to 10.0-10.5 with 20% NaOH solution.

[0047] 2. Dissolve 10.5g of β-carotene crystals, 1.0g of BHT, and 2.0g of VE oil in 210.0g of chloroform, and stir until completely dissolved.

[0048] 3. Under high stirring and high shear conditions, add oil phase B to water phase A, then emulsify at a stirring speed of 2900-18000rpm for 15 minutes, then raise the temperature to 50°C to remove the solvent and form a microemulsion. Wherein, the obtained microemulsion is a sub-nanometer microemulsion, its average particle size is 130-200nm, and the pH of the microemulsion is 9-10; high stirring and high shearing means: the shearing power is: 0.5-100Kw, The stirring speed is 2900-18000 rpm.

[0049] 4. Spray-dry the microemulsion to make β-carotene particles.

[0050] Refer to Table 2 and figure 2 , in the β-ca...

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Abstract

The invention discloses a good microencapsulation method for carotenoid. The method comprises the following steps of: 1) fully dissolving protective colloid, sucrose or glucose, vitamin C palmitate, ethylene diamine tetraacetic acid (EDTA) and tea saponin in water, and adjusting the pH to be 10 to 11 to obtain a water phase A; 2) fully dissolving the carotenoid and an antioxidants in a solvent to obtain an oil phase B; 3) under high-shear and high-agitation conditions, adding the oil phase B into the water phase A, emulsifying to form colostrum by stirring at a high speed, heating and removing the solvent to obtain a microemulsion; and 4) adding the obtained microemulsion into a spray drying system to obtain carotenoid particles or powder after spray drying. The carotenoid particles or powder prepared by the method has the characteristics of high dispersibility, high stability, high light permeability and small particle size, and meanwhile has the characteristics that the embedding rate is high and the washout content is less than 1 percent.

Description

technical field [0001] The invention relates to a preparation method of carotenoid granules or powder, in particular to a good microencapsulation method of carotenoid. Background technique [0002] At present, the important role of carotenoids, such as β-carotene, cantharidin, astaxanthin, etc. as feed colorants, food colorants or food additives has been recognized by people. In recent years, there have been many reports on the functional role of carotenoids. However, carotenoids are insoluble in water, have a high melting point, and are sensitive to light, heat, and oxygen. These properties of carotenoids are particularly unfavorable for the coloring of aqueous media, since due to their water insolubility it is extremely difficult to achieve a uniform or sufficiently intense coloring effect. In the case of canthaxanthin (canthaxanthin), these properties, in particular water insolubility, lead to very limited bioavailability in pharmaceutical dosage forms containing said c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23P1/04A23L1/27A23L5/40A23P10/30
Inventor 刘庆辉杨伟涛朱萍
Owner 肇庆巨元生化有限公司
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