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Curcumin and mixed-cyclodextrin inclusion compound and preparation method thereof

A technology of mixing cyclodextrin and inclusion compound, which is applied in the field of medicine, can solve the problems of low solubility and low inclusion rate, and achieve the effect of high inclusion rate, simple operation and improved inclusion rate

Inactive Publication Date: 2013-09-04
江苏丰园生物技术有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0007] The technical problem to be solved in the present invention is: to overcome the shortcomings of the β-cyclodextrin inclusion compound of curcumin, such as low inclusion rate and low solubility

Method used

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  • Curcumin and mixed-cyclodextrin inclusion compound and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1: Research on inclusion process of curcumin and mixed cyclodextrin

[0018] (1) Determination of the optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0019] Three different ratios of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin were selected. After many experiments, the mixed cyclodextrins containing different proportions were packaged at the same temperature and inclusion time. According to the level of inclusion rate, select the best ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin. The data in Table 1 are obtained through experiments:

[0020] Table 1 Determination table of optimal ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin

[0021]

[0022] Cyclodextrin cyclodextrin CD for short.

[0023] It can be seen from the experimental results that when the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1 by weight, the inclusion rate of curcumin is the highest.

Embodiment 2

[0025] Mix 12 parts of cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1), with 75 parts of water and 2 parts of 95% ethanol solution Mix, heat to 70°C to dissolve, cool to 55°C, add 2 parts of curcumin dropwise, and use a shearing machine to stir at 5000r / min for inclusion, keep the system temperature between 50-55°C, and cut for 50 minutes After passing the microscopic examination of the clathrate, the temperature was naturally lowered to room temperature, and the curcumin clathrate solution was spray-dried to obtain the product. The curcumin clathrate rate was 80.1%.

Embodiment 3

[0027] Mix 10 parts of cyclodextrin (the ratio of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin is 6:4:1), with 70-80 parts of water, 2 parts of 95% Mix the ethanol solution, heat to 70°C to dissolve, cool to 55°C, add 1 part of curcumin dropwise, and use a shearing machine to stir at 5000r / min for clathrate, keep the system temperature between 50-55°C, and cut 50 Minutes later, after passing the microscopic examination of the clathrate, the temperature was naturally lowered to room temperature, and the curcumin clathrate solution was spray-dried to obtain the product. The clathrate rate of curcumin was 90.1%.

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Abstract

The invention belongs to the technical field of medicines, and in particular relates to a curcumin and mixed-cyclodextrin inclusion compound and a preparation method thereof. The technical scheme provided by the invention is as follows: an alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin mixture and curcumin are adducted in a low-concentration ethanol-water solution, the inclusion rate is improved, and the dissolvability and the stability are enhanced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an inclusion compound of curcumin and mixed cyclodextrin and a preparation method thereof. Background technique [0002] Turmeric has been widely used as food since ancient times. With the advancement of science and technology, people's understanding of turmeric and its main component curcumin has gradually deepened, and it has been found that curcumin has a wide range of medicinal effects. [0003] Curcumin not only has the effects of anti-human immunodeficiency virus (HIV), anti-cell aberration, and inhibition of platelet coagulation nuclei thrombosis, but also can scavenge oxygen free radicals, reduce lipid peroxide in blood and liver, and present a good hepatoprotective effect , can significantly reduce the total liposterol content, increase serum high-density lipoprotein content, reduce serum low-density lipoprotein content, and has a significant effect of lowering blood li...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K31/12A61P31/18A61P7/02A61P1/16A61P3/06
Inventor 徐文峰
Owner 江苏丰园生物技术有限公司
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