Coenzyme Q10 inclusion compound and preparation technology thereof
A clathrate and coenzyme technology, which is applied in food science, drug combination, medical preparations of non-active ingredients, etc., can solve the problems of low bioavailability, large weight ratio, large amount of cyclodextrin, etc. Combine rate, improve stability, reduce ratio effect
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Embodiment 1
[0038] Formula: 0.5g coenzyme Q10; 3g hydroxypropyl-β-cyclodextrin; 50g mannitol
[0039] Process: Add coenzyme Q10 to saturated aqueous solution of hydroxypropyl-β-cyclodextrin, stir with an electric stirrer at 50°C for 30 minutes to accelerate the dissolution of coenzyme Q10 to obtain a clathrate solution, and then add clathrate Mannitol is added into the solution, and clathrate powder is obtained after washing and drying. The clathrate powder is placed in a tablet machine and compressed into tablets.
Embodiment 2
[0041] Recipe: 1g coenzyme Q10; 8g β-cyclodextrin; 100g starch
[0042] Process: add coenzyme Q10 to β-cyclodextrin aqueous solution, stir well to prepare coenzyme Q10-encapsulated clathrate solution, then add starch to the clathrate solution, and dry the solution into Clathrate powder. Add the clathrate powder into a granulator to obtain granules, and make granules.
Embodiment 3
[0044] Formula: 8g coenzyme Q10; 5g sulfobutyl ether-β-cyclodextrin; 550g sorbitol
[0045] Process: Dissolve coenzyme Q10 and sulfobutyl ether-β-cyclodextrin in water, stir to dissolve to obtain clathrate solution, then add sorbitol to clathrate solution, sublimate water by lowering temperature and pressure, A dry clathrate powder is obtained. The clathrate powder is pulverized again with a grinder to make a powder.
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