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a gel base

A gel and matrix technology, applied in the field of medicine, can solve the problems of poor tissue compatibility, insufficient solubility, poor bearing capacity, etc., and achieve the effects of simple application and operation, prolonging the action time, and improving the stability of chemical properties

Active Publication Date: 2016-03-09
北京中美联医学科学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of "drying out phenomenon", poor bearing capacity, insufficient solubility, poor tissue compatibility and easy allergy to patients in the prior art.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A gel base, prepare a predetermined amount of 1000 grams:

[0055]

[0056] Preparation:

[0057] Prepare A, B and gel base separately:

[0058] Component A: 50g of hydroxypropyl methylcellulose, 20g of alginate, 14g of sodium hyaluronate and 15g of chondroitin sulfate were weighed and mixed thoroughly, then placed in a container, and 100g of propylene glycol solution with a concentration of 90% Pour it into the container and stir it thoroughly with a stir bar to form component A of the dispersion liquid, wherein the temperature of component A in the dispersion process is not greater than 30°C;

[0059] Component B: Fill the container with 300 grams of propylene glycol solution with a concentration of 45%. While stirring with a stir bar, mix it and let it stand naturally for more than 24 hours. After the solute in the container is fully swollen, make a half The ready-to-use swelling liquid component B, wherein the swelling liquid component B is not higher than 45°C...

Embodiment 2

[0062] A gel base, prepare a predetermined amount of 1000 grams:

[0063]

[0064] Preparation:

[0065] Prepare A, B and gel base separately:

[0066] Component A: 40g of sodium carboxymethylcellulose, 30g of cyclodextrin, 20g of albumin and 9g of sodium hyaluronate are weighed and mixed thoroughly, then placed in a container, and 100g of ethanol solution with a concentration of 90% is poured into the In the container, fully stir with a stirrer to form component A of the dispersion, wherein the temperature during the dispersion process of component A is not greater than 30°C;

[0067] Component B: Fill the container with 300 grams of 50% ethanol solution. While stirring with a stirrer, mix well and let it stand naturally for more than 24 hours. After the solute in the container is fully swollen, it will be semi-fluid. Component B of the standby swelling solution, wherein the temperature during the swelling process of component B is not greater than 45°C;

[0068] Gel ma...

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Abstract

The invention provides a gel matrix and a preparation method thereof, and the gel matrix is used for preparation of gel dosage form drugs. The gel matrix provided by the invention includes: 0.5-10% of gel, 0.1%-10% of a tissue stabilizer, 0.1%-10% of a tissue repair agent, 0.5%-5% of a transdermal enhancer, 1%-10% of a non-water solvent with concentration higher than 90% and water, or a non-water solvent with concentration not more than 50%. The gel matrix provided by the invention has certain leveling property (uniformity), flexibility and moisture retention, so as to reduce the ''parching'' phenomenon. The gel matrix provided by the invention has strong ability of bearing and releasing drugs to satisfy quantitative addition of medicinal ingredient and guarantee stability and uniformity of drug storage and drug concentration in a course of treatment. The gel matrix provided by the invention can improve release rate, percutaneous absorption rate and safe treatment of the drug. The invention can increase tissue compatibility of the preparation, properly prolong action time and application frequency, so as to increase effectiveness and reduce the occurrence of local side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gel matrix. Background technique [0002] There are three main types of known medical gels: one is semi-solid gels, such as external gels and gelatin / oil / water composite emulsions; the other is solid gels, such as mosaic microcapsules or microspheres; The third is oily thixotropic gel, such as aluminum stearate vegetable oil thixotropic gel. The first type of gel drug has strong advection and thixotropy, fast diffusion, poor sustained release, high drug fluidity, and is difficult to retain in the local area. The total amount of drug application cannot be guaranteed, and it is prone to drying out; the second type Gel-like excipients are used more and drug encapsulation is less; the third type of gel contains too much oil and is not suitable for water-soluble drugs. [0003] Medical semi-solid gels in the prior art, such as gels for external use, hydrated gelatin, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/42A61K47/40A61K47/38A61K47/36
Inventor 郑淑丽翁春晓
Owner 北京中美联医学科学研究院有限公司
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