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Blank gel

A gel and blank technology, applied in the field of medicine, can solve the problems of easy water loss and mildew, and achieve the effects of not easy to mildew and water loss, excellent biocompatibility, and prolonging the action time

Inactive Publication Date: 2017-05-24
谭惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing water-based gels are generally prone to dehydration and mildew, so it is of practical significance to develop a gel matrix with good stability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Preparation method: take the prescribed amount of carbomer and add appropriate amount of water and stir at room temperature to make it swell and dissolve; then take the prescribed amount of peppermint oil, laurocapram, hyaluronic acid, chondroitin sulfate, glycerin and ethylparaben Add the remaining amount of water and stir at room temperature to dissolve it, and add it to the carbomer aqueous solution; add an appropriate amount of triethanolamine to adjust the pH value of the mixed solution to 6.5-7.5, and stir evenly at room temperature to obtain the product.

Embodiment 2

[0022]

[0023]

[0024] Preparation method: take the formula amount of cross-linked polyvinylpyrrolidone, add appropriate amount of water and stir to dissolve completely; Stir the remaining water at normal temperature to dissolve it, add it to the aqueous solution of cross-linked polyvinylpyrrolidone, continue to stir and cool to normal temperature to obtain the product.

Embodiment 3

[0026]

[0027] Preparation method: take the formula amount of cross-linked polyvinylpyrrolidone, add appropriate amount of water and stir to dissolve completely; then take the formula amount of peppermint oil, laurocapram, hyaluronic acid, chondroitin sulfate, propylene glycol and phenoxyethanol and add the balance Stir the water at room temperature to dissolve it, add it to the cross-linked hypromellose aqueous solution, and continue stirring at room temperature until it is uniform.

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Abstract

The invention provides a blank gel. The blank gel comprises the following components by weight percentage: 5-15% of gel matrix, 1-5% of a transdermal absorption enhancer, 1-5% of a humectant, 0.5-3% of a cosolvent, 0.1-0.5% of a preservative and a proper amount of deionized water. The blank gel is suitable for a water soluble medicine, has the capabilities of bearing and releasing the medicines, meets the requirement of quantitatively adding the ingredients of the medicine conveniently, guarantees stability and uniformity of medicine storage and medicine concentration in the treatment process, is good in stability, and does not mildew or dehydrate easily.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a blank gel. Background technique [0002] Ointment is a relatively classic dosage form. In ancient times, there was such a medicine as ointment, and a transdermal drug delivery system has been developed in modern times. The transdermal drug delivery system is a drug dosage form that uses the skin as a drug delivery channel. It has the advantages of constant and long-lasting release of drugs into the systemic circulation through the skin, avoiding drug decomposition in the digestive tract, and reducing damage to the stomach and liver. [0003] Gels in transdermal preparations are more and more popular due to their transparent appearance, smooth feel and non-contamination of clothing. However, the existing water-based gels are generally prone to dehydration and mildew, so it is of practical significance to develop a gel matrix with good stability. Contents of the invention ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K47/38A61K47/36A61K47/46
Inventor 谭惠娟
Owner 谭惠娟
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