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Application of pidotimod as immune enhancer on livestock and poultry

A technology of pidotimod, livestock and poultry, applied in the field of application of pidotimod as an immune booster in livestock and poultry, can solve problems such as application and research gaps, no relevant reports, etc., to improve the immune function of the body, improve antibody Low level, acute and chronic toxic effects

Inactive Publication Date: 2013-07-03
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although pidotimod is widely used in the treatment of human diseases as an immune enhancer, the application and research of pidotimod in livestock and poultry production is still blank at home and abroad, and there is no relevant report

Method used

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  • Application of pidotimod as immune enhancer on livestock and poultry
  • Application of pidotimod as immune enhancer on livestock and poultry
  • Application of pidotimod as immune enhancer on livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The basal ration is made according to the nutritional needs of piglets in the American NRC (1998 edition), formula: 58.5% corn, 24.5% soybean meal, 6.5% subflour, 7.0% puffed soybean, 4.5% fish meal, 3.0% whey powder, 1.0 calcium hydrogen phosphate %, stone powder 1.1%, salt 0.3%, L-lysine 0.1%, multidimensional trace element premix 1.0%. Main nutritional indicators: crude protein 19.5%, calcium 0.86%, phosphorus 0.71%, lysine 1.14%, methionine plus cystine 0.62%.

[0016] 126 healthy piglets were randomly divided into 7 groups, with 3 replicates in each group and 6 piglets in each replicate. Pidotimod was added to the basal diet at levels of 25, 50, 100, 150, 200, 300 g / t feed. Free access to food and water, the test period was 28 days. Record food consumption, fasting weight and final weight. After the feeding experiment, blood was collected from the jugular vein of 6 pigs with similar body weight in each group, and part of the whole blood was used to determine the...

Embodiment 2

[0025] test results

[0026] Changes in Newcastle disease antibody titer At 21, 28 and 35 days of age, the HI value of each dose group of pidotimod was significantly higher than that of the vaccine control group (P figure 1 Shown:

[0027] Dynamic changes of lymphocyte proliferation At 21 days of age, the A570 values ​​of pidotimod high and medium dose groups and the drug control group were significantly higher than those of the other two groups (P 0.05). At the age of 35 days, the A570 values ​​of the pidotimod high-dose and middle-dose groups and the drug control group were significantly higher than those of the other two groups (P<0.05) (Table 3).

[0028] Table 3 Dynamic changes of lymphocyte proliferation in each group (A570 value)

[0029] group 21d 35d drug high dose 0.485±0.0393a 0.445±0.0378a drug dose 0.448±0.0343a 0.432±0.0598a low dose drug 0.378±0.0397b 0.322±0.0500b drug control 0.453±0.0308a 0.415±0.0187a ...

Embodiment 3

[0036] Test drugs: 50% carbasalate calcium soluble powder, pidotimod soluble powder.

[0037] Clinical symptoms: The chicken stretches its neck and opens its mouth to breathe, closes its eyes and takes a nap, discharges a small amount of green feces, has mucus in the mouth, and reduces feed intake. Treatment with astragalus polysaccharide had little effect and increased mortality. There is a process of pulling water in large groups.

[0038] Autopsy analysis: autopsy findings: some chickens have bleeding points in the throat, mucus in the trachea, most chickens have pericardium, liver packs, tracheitis, peritonitis, etc., a small amount of bleeding from the glandular papilla, bleeding and ulcers at the junction of the glandular stomach and gizzard , Gizzard corneum ulcers, submembrane bleeding or ulcers, intestinal bleeding, ileal lymphoid follicle swelling or bleeding in the form of jujube pits, cecal tonsil bleeding, rectal bleeding, and a certain amount of yellow-green sto...

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Abstract

The invention discloses an application of pidotimod as a medicine used for treating livestock and poultry immunosuppressive diseases. According to the invention, pidotimod is added in drinking water or feedstuff of livestock and poultry such as pig, chicken, cattle, sheep, and the like, wherein the concentration of pidotimod is 10-1000ppm. With the technical scheme provided by the invention, livestock and poultry immune functions can be enhanced, growth can be promoted, and various livestock and poultry immunosuppressive diseases can be prevented and treated.

Description

technical field [0001] The invention relates to the application of pidotimod as a medicine for treating immunosuppressive diseases of livestock and poultry. Background technique [0002] Pidotimod ((R)-3-[(S)-(5-oxo-2-pyrrolidinyl)carbonyl]-tetrahydrothiazole-4-carboxylic acid), the English name is Pidotimod. Its formula C 9 h 12 N 2 o 4 S. Pidotimod is a synthetic dipeptide immunostimulant, which produces immune effects by promoting the proliferation of lymphocytes and stimulating the production of interleukin-2 and r-interferon. Non-specific immunity has obvious promotion effect. [0003] Experiments have shown that pidotimod can promote the body's cellular and humoral immune functions, and can also promote the activity of macrophages. For experimental bacterial infection in mice, combined use with antibiotics has superimposed or synergistic therapeutic effect; it also has obvious preventive effect on low-dose viral infection in mice. Pidotimod is an immune booster...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61P37/04A23L1/305
CPCY02A40/70
Inventor 郑文陈洪量
Owner QILU ANIMAL HEALTH PROD
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