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Preparation method of flavonoid medicine for treating frostbite

A technology of flavonoids and medicaments, applied in the field of preparation of flavonoids, can solve the problems of not being able to be widely used, lack of basic research, preparation retention, etc., and achieve the effects of being conducive to popularization and application, simple extraction process, and simple formula

Inactive Publication Date: 2013-07-03
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many effective experience prescriptions for treating frostbite with traditional Chinese medicine, but most of the existing preparations stay at the level of hospital prescription preparations and cannot be widely used
Moreover, the existing formulations are complicated, the basic research is lacking, and the traditional formulations are the main ones.
There are certain defects in traditional dosage forms, such as inconvenient use of decoction, wine and tincture are irritating to the skin, and it is not suitable to apply to damaged skin, ulcers and wounds; it is not suitable for frostbite that has been ulcerated, and it is easy to cause contact Disadvantages such as dermatitis

Method used

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  • Preparation method of flavonoid medicine for treating frostbite
  • Preparation method of flavonoid medicine for treating frostbite
  • Preparation method of flavonoid medicine for treating frostbite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 Weigh 500g of fresh cherries, wash and mash them, and remove the pits to obtain about 400ml of stock solution. Add 75% ethanol containing 1% hydrochloric acid at a volume ratio of 1:4, extract at an ultrasonic frequency of 40KHz for 40min, and reflux for 2h. Concentrate under pressure to make the alcohol content reach 75%, then stand in the dark at 4°C for 12h (precipitate removal of protein, polysaccharide, etc.), filter to remove the precipitate, and place the filtrate in a rotary evaporator to concentrate under reduced pressure to nearly dryness. Suspend and disperse the concentrate in water, filter to remove insoluble matter, put the filtrate into a polyamide column, add 30 times the amount of polyamide in water for elution, discard the eluent, and then elute with 90% ethanol until the eluent is free of color, collect the eluate and concentrate under reduced pressure, and vacuum freeze-dry the concentrate to obtain flavonoids. Using the HPLC method and usi...

Embodiment 2

[0057] The preparation of embodiment 2 ointment flavonoids:

[0058] The flavonoids prepared in Example 1 and glyceryl monostearate, stearic acid, and glycerin (oil phase) are placed in an evaporating dish, melted on a water bath at 80° C., and then white vaseline, liquid paraffin, twelve Sodium alkyl sulfate, triethanolamine, and ethylparaben (water phase) were heated to 80°C on a water bath, and the water phase was added to the oil phase solution, and stirred in the same direction until uniform. Keep stirring at 80°C for 1-2 minutes, then transfer to a cold water bath and stir to room temperature.

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Abstract

The invention relates to a preparation method of a flavonoid medicine for treating frostbite, which comprises the following steps: weighting fresh nanking cherry, washing and crushing, removing the shell to obtain a basic solution, adding 75% of ethanol containing 1% of hydrochloric acid with volume ratio of 1:4, wherein the ultrasonic frequency is 40KHz, extracting for 10-60 minutes, performing backflow extraction for 1-6 hours, performing pressure reduction and concentrating to alcohol amount at 75%, then standing away from light for 6-18 hours and filtering the deposition, and placing a filtrate in a rotary evaporation instrument for performing pressure reduction and concentrating to a dry state, suspending a concentrate and dispersing in water, filtering to remove an insoluble substance, filling the filtrate in a polyamide column, adding water with 30 times amount of polyamide for eluting, removing an eluate, adding 90% of ethanol for eluting to make the eluate transparent, collecting the eluate and performing pressure reduction and concentrating, and performing vacuum freeze drying on a concentrate to obtain the flavonoid medicine. The flavonoid medicine for treating frostbite has the characteristics of single component, definite therapeutic effect and convenient usage.

Description

technical field [0001] The invention relates to a preparation method of a flavonoid agent for treating frostbite. Background technique [0002] The chemical drug treatment of frostbite is generally used steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, vasoactive drugs, anti-platelet drugs and blood volume expansion drugs. The traditional Chinese medicine treatment of frostbite requires dispelling cold, promoting blood circulation and removing blood stasis, softening damaged tissue, improving blood circulation and preventing infection. [0003] There are many traditional methods for treating frostbite, some of which treat frostbite with ten drops of water, compound anisodamine ulcerative chilblain film, anisodamine, Chinese herbal chilblain ointment, frostbite varnish, chilblain, Fengtongling, pepper ointment, etc. ; Some use family-traded Taogui decoction (including peach kernel, cinnamon stick, ginger, etc.) to treat frostbite; Treat frostbite on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/06A61P17/02A61P29/00A61P37/02
Inventor 张成义王喜斌陈曦
Owner BEIHUA UNIV
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