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Benzoic acid alogliptin composition troche and preparation method thereof

A technology of benzoic acid and composition, applied in the field of alogliptin benzoate composition tablet and preparation thereof, can solve the problems of insufficient insulin secretion, slow disintegration speed, inconvenient use and the like, and achieves easy control of the technological process, Fast disintegration and easy portability

Inactive Publication Date: 2013-06-19
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Some patients with type 2 diabetes mainly have insulin resistance. Most patients are obese. Due to insulin resistance, insulin sensitivity decreases, and blood insulin increases to compensate for their insulin resistance. However, compared with patients with high blood sugar, insulin secretion is still relatively insufficient.
[0006] It was first produced by Japan's Takeda Company, but it has the disadvantages of slow disintegration, low dissolution rate and inconvenient use

Method used

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  • Benzoic acid alogliptin composition troche and preparation method thereof
  • Benzoic acid alogliptin composition troche and preparation method thereof
  • Benzoic acid alogliptin composition troche and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Produce 1000 specifications and be the alogliptin benzoate composition tablet of 25mg, the medicine active ingredient of described alogliptin benzoate composition tablet is alogliptin benzoate, mannitol, microcrystalline cellulose, The dosages of croscarmellose sodium, magnesium stearate and 5% hydroxypropyl cellulose aqueous solution are shown in Table 2.

[0041]Concrete preparation steps are as follows:

[0042] The first step: sieving, passing alogliptin benzoate through a 100-mesh sieve, and passing mannitol, microcrystalline cellulose and croscarmellose sodium through a 80-mesh sieve respectively;

[0043] The second step: mixing, mixing the sieved alogliptin benzoate, mannitol, microcrystalline cellulose and croscarmellose sodium evenly to obtain the first mixture, set aside;

[0044] The third step: granulation, adding the weighed 5% hydroxypropyl cellulose aqueous solution into the first mixture to make soft material, and granulating after passing through a 24...

Embodiment 2

[0053] Produce 1000 specifications and be the alogliptin benzoate composition tablet of 12.5mg, the drug active ingredient of described alogliptin benzoate composition tablet is alogliptin benzoate, mannitol, microcrystalline cellulose , croscarmellose sodium, magnesium stearate and 5% hydroxypropyl cellulose aqueous solution, the consumption of each raw material is as shown in table 4.

[0054] Concrete preparation steps are as follows:

[0055] The first step: sieving, passing the active ingredient alogliptin benzoate through a 100-mesh sieve, and passing mannitol, microcrystalline cellulose and croscarmellose sodium through a 80-mesh sieve;

[0056] The second step: mixing, mixing the sieved alogliptin benzoate, mannitol, microcrystalline cellulose and croscarmellose sodium evenly to obtain the first mixture, set aside;

[0057] The third step: granulation, adding the weighed 5% hydroxypropyl cellulose aqueous solution into the first mixture to make soft material, and gran...

Embodiment 3

[0065] Adopt the alogliptin benzoate composition tablet of embodiment 1 to make the alogliptin benzoate composition film-coated tablet that specification is 25mg, formula is as follows:

[0066]

[0067] The preparation method is as follows:

[0068] Step 1: Weigh the Opadry coating powder and water, mix to make a coating solution, and set aside;

[0069] Step 2: Weigh the alogliptin benzoate composition tablet and put it in the coating pot, adjust the rotating speed of the coating pot to 5-10 rpm, control the inlet air temperature to 55-65°C and blow hot air to make the plain tablet temperature When it reaches 35-45°C, spray the coating liquid described in step (1) until the coating weight increases by 2.0% to 4.0%, stop spraying the coating liquid, and decide whether to continue to rotate the coating pan according to the degree of adhesion of one side, and then proceed to drying , to obtain the alogliptin benzoate composition film-coated tablet.

[0070] Influencing fac...

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Abstract

The invention relates to the field of pharmacy, and discloses a benzoic acid alogliptin composition troche and a preparation method thereof. The effective components of the benzoic acid alogliptin composition troche comprise benzoic acid alogliptin, mannitol, microcrystalline cellulose, croscarmellose sodium, magnesium stearate and 5% hydroxy propyl cellulose aqueous liquor. The synthetic materials are easy to obtain and low in cost. The troche is quick in disintegration speed, high in dissolution rate, good in stability, accurate in dosage and convenient to take and carry. The benzoic acid alogliptin composition troche is simple in step, short in production period, low in production cost and suitable for industrialized application, and the technical process is easy to control,.

Description

technical field [0001] The invention relates to the medical field, and discloses an alogliptin benzoate composition tablet and a preparation method thereof. Background technique [0002] Type 2 diabetes mellitus is a type of blood sugar caused by a variety of metabolic disorders, including insufficiency of insulin secretion, impaired hepatic response and peripheral tissue of insulin, progressive loss of β cells, disturbance of glucagon secretion and disturbance of incretin Control disorder. The incidence of the disease is increasing year by year worldwide and is expected to increase from 2.8% in 2000 to 4.4% in 2030. The total number of people with the disease rose from 171 million in 2000 to 366 million in 2030. [0003] Some patients with type 2 diabetes are mainly insulin resistant. Most patients are obese. Due to insulin resistance, insulin sensitivity decreases, and blood insulin increases to compensate for their insulin resistance. However, compared with patients wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/30A61K31/513A61K47/38A61P3/10
Inventor 张彦赵树楷韩后良徐淑周
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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