Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy

Abstract

The invention discloses oral medical ice for preventing and treating dental ulcer and infection after chemotherapy. The oral medical ice includes normal saline; each 100ml of normal saline includes 50-100 micrograms of grain-macrophage colony stimulating factor, 30-100mg of calcium folinate and 250-500mg of lidocaine hydrochloride; and the oral medical ice can be acquired after the normal saline including the above components is frozen to ice. The oral medical ice is used for preventing and treating dental ulcer and infection after high-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy; and the oral medical ice without the calcium folinate can also be used for preventing and treating dental ulcer and infection after other chemotherapies. The oral medical ice disclosed by the invention can be used for alleviating pain, contracting the blood vessels of the oral mucosa, reducing exudation and increasing salivary secretion and can be beneficial to the cleaning of the mouth. The oral medical ice can be slowly molten in the mouth; and the lasting time of the oral medical ice is longer than the time for rinsing the mouth by using collutory. The oral medical ice can be used for improving the chemotherapy tolerance of a patient, promoting the restoration of the oral mucosa ulcer surface, shortening the curing time and reducing the pain of the patient and has no side effects, thereby having good application prospect.

Description

Technical field [0001] The invention relates to a mouth ice, in particular to a mouth ice for preventing and treating oral ulcers and infections after chemotherapy, and belongs to the technical field of auxiliary treatment drugs after chemotherapy. Background technique [0002] After chemotherapy, the patient's drinking and eating decreased, the self-cleaning effect of the oral cavity was weakened, and the normal bacterial flora of the oral parasitic proliferated, producing indole, sulfhydryl and amines, etc., causing bad breath, destroying the oral environment, and causing damage to the oral mucosa; The dose of chemotherapy inhibits the proliferation of oral mucosal epithelial cells, and the secretion of salivary glands is reduced, which reduces the repair and barrier function of the oral mucosa; the application of broad-spectrum antibiotics can easily lead to the imbalance of oral flora, with neutrophils lower than 0.5×10 9 / L is a key factor in the occurrence of oral infections...

AI Technical Summary

Problems solved by technology

So far, the commonly used drugs for the prevention and treatment of oral ulcers and infections are mainly anti-infective mouthwash drugs with different components, but there are few drugs aimed at promoting the repair of oral mucosa