Oral medical ice for preventing and treating dental ulcer and infection after chemotherapy

A technology for oral ulcers and normal saline, applied in the field of oral ice and mouth ice for the prevention and treatment of oral ulcers and infections after chemotherapy, can solve the problems of rare oral mucosa repair, shorten the healing time, improve tolerance, promote repaired effect

Inactive Publication Date: 2013-06-12
HOSPITAL ATTACHED TO QINGDAO UNIV
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the commonly used drugs for the prevention and treatment of oral ulcers and infections are mainly anti-infective mouthwash drugs with different components, but there are few drugs aimed at promoting the repair of oral mucosa

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] An oral ice for the prevention and treatment of oral ulcers and infections after chemotherapy, including physiological saline, which is characterized in that every 100ml of physiological saline contains the following components: granule-macrophage colony stimulating factor (GM-CSF) 50ug-100ug, leucovorin Calcium (CF) 30-100mg, lidocaine hydrochloride 250mg-500mg; put the physiological saline containing the above ingredients in a sterile container and freeze it into ice.

[0021] The above oral ice is used for the prevention and treatment of oral ulcers and infections after high-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy. Large dose refers to more than 3g / m 2 , That is, the dosage is determined by the body surface area.

[0022] The above-mentioned preparation method of oral ice for preventing and treating oral ulcers and infections after chemotherapy includes adding the following components in order to every 100ml of normal saline: granule-macrophage colon...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses oral medical ice for preventing and treating dental ulcer and infection after chemotherapy. The oral medical ice includes normal saline; each 100ml of normal saline includes 50-100 micrograms of grain-macrophage colony stimulating factor, 30-100mg of calcium folinate and 250-500mg of lidocaine hydrochloride; and the oral medical ice can be acquired after the normal saline including the above components is frozen to ice. The oral medical ice is used for preventing and treating dental ulcer and infection after high-dose methotrexate chemotherapy or 5-fluorouracil chemotherapy; and the oral medical ice without the calcium folinate can also be used for preventing and treating dental ulcer and infection after other chemotherapies. The oral medical ice disclosed by the invention can be used for alleviating pain, contracting the blood vessels of the oral mucosa, reducing exudation and increasing salivary secretion and can be beneficial to the cleaning of the mouth. The oral medical ice can be slowly molten in the mouth; and the lasting time of the oral medical ice is longer than the time for rinsing the mouth by using collutory. The oral medical ice can be used for improving the chemotherapy tolerance of a patient, promoting the restoration of the oral mucosa ulcer surface, shortening the curing time and reducing the pain of the patient and has no side effects, thereby having good application prospect.

Description

Technical field [0001] The invention relates to a mouth ice, in particular to a mouth ice for preventing and treating oral ulcers and infections after chemotherapy, and belongs to the technical field of auxiliary treatment drugs after chemotherapy. Background technique [0002] After chemotherapy, the patient's drinking and eating decreased, the self-cleaning effect of the oral cavity was weakened, and the normal bacterial flora of the oral parasitic proliferated, producing indole, sulfhydryl and amines, etc., causing bad breath, destroying the oral environment, and causing damage to the oral mucosa; The dose of chemotherapy inhibits the proliferation of oral mucosal epithelial cells, and the secretion of salivary glands is reduced, which reduces the repair and barrier function of the oral mucosa; the application of broad-spectrum antibiotics can easily lead to the imbalance of oral flora, with neutrophils lower than 0.5×10 9 / L is a key factor in the occurrence of oral infections...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/00A61P1/02A61P31/02A61K31/519A61K31/167
Inventor 孙爱莲赵云江秀丽姜爱卿王薇
Owner HOSPITAL ATTACHED TO QINGDAO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap