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Sustained-release sticking film for treating oral ulcer

An oral ulcer and sustained-release technology is applied in the field of sustained-release film for the treatment of oral ulcers, which can solve the problems that the lesion site cannot reach the drug concentration, the drug sticker stays short, and affects the drug load of the drug sticker, so as to promote wound healing. , The effect of long local action time and large drug load

Active Publication Date: 2013-06-12
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the currently commonly used oral ulcer treatment plasters, the main problem is: due to the special physiological environment of the oral cavity, most of the plasters stay in the oral cavity for a short time, and it is difficult to adapt to the characteristics of the oral cavity to achieve continuous effective drug concentration in the lesion.
In order to prolong the adhesion time of the patch in the oral cavity and make it suitable for the physiological structure and environment of the oral cavity, the patch is often prepared into a thin film with a certain degree of flexibility, but this will affect the drug loading of the patch. Lesion site does not reach effective drug concentration
However, it is difficult to prepare a thin film with sufficient drug loading

Method used

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  • Sustained-release sticking film for treating oral ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Dissolve drug-loaded substances: borneol, artificial bezoar, dexamethasone acetate, vitamin B2, glycerin, dextrin, carbomer, polyethylene glycol and sodium carboxymethylcellulose in 100ml of distilled water, and use The dipping method is to stand still at 70° C. for 1 hour to allow the drug-loaded substance to enter the bacterial cellulose membrane, and freeze-dry to obtain the bacterial cellulose / drug-loaded substance composite membrane.

[0023] raw material serving size ice flakes 0.5g artificial bezoar 1g Dexamethasone acetate 1g Vitamin B2 0.5g glycerin 2g dextrin 2g carbomer 3g polyethylene glycol 3g Sodium carboxymethyl cellulose 3g distilled water 100ml

[0024] (2) Dissolve ethyl cellulose and sodium alginate in distilled water at 70°C to prepare a 1% by weight mixed aqueous solution of ethyl cellulose and sodium alginate. It is coated on the upper surface of the bacterial cellulose / ...

Embodiment 2

[0030] (1) Dissolve drug-loaded substances: a mixture of borneol, artificial bezoar, dexamethasone acetate, glycerin, dextrin, carbomer, polyethylene glycol and sodium carboxymethyl cellulose in 100ml of distilled water, and soak in Stand still at 30° C. for 4 hours to allow the drug-loaded substance to enter the bacterial cellulose membrane, and freeze-dry to obtain a bacterial cellulose / drug-loaded substance composite membrane.

[0031] raw material serving size ice flakes 0.5g artificial bezoar 0.5g Dexamethasone acetate 1g glycerin 1g dextrin 2g carbomer 3g polyethylene glycol 1g Sodium carboxymethyl cellulose 4g distilled water 100ml

[0032] (2) Dissolve carboxymethyl cellulose in distilled water at 50°C to prepare a 5% carboxymethyl cellulose aqueous solution. It is coated on the upper surface of the bacterial cellulose / drug-loaded substance composite film by a coating machine, and dried at 50°C to for...

Embodiment 3

[0038] (1) Dissolve the drug-loaded substance: a mixture of borneol, dexamethasone acetate, glycerin, dextrin, carbomer, polyethylene glycol and sodium carboxymethylcellulose in 100ml of distilled water, and soak it in 50°C Stand still for 3 hours to allow the drug-loaded substance to enter the bacterial cellulose membrane, and freeze-dry to obtain a bacterial cellulose / drug-loaded substance composite membrane.

[0039] raw material serving size ice flakes 1g Dexamethasone acetate 2g glycerin 1g dextrin 1g carbomer 2g polyethylene glycol 2g Sodium carboxymethyl cellulose 4g distilled water 100ml

[0040] (2) Dissolve hydroxyethyl cellulose in distilled water at 60°C to prepare a 2% carboxymethyl cellulose aqueous solution by weight. It is coated on the upper surface of the bacterial cellulose / drug-loaded substance composite film by a coating machine, and dried at 40°C to form a slow-release coating of a slow-releas...

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Abstract

The invention discloses a sustained-release sticking film for treating oral ulcer and relates to the technical field of medical equipment and preparation technology thereof. The sustained-release sticking film is of a circular sheet and provided with a three-layer structure, wherein the upper layer is a sustained-release coating (1) which contacts with an oral ulcer surface, the lower layer is a polyacrylic acid film (3) with a protective effect, a medicament-loaded layer of the middle layer takes bacterial cellulose as a medicament carrier, and a medicament loading substance with a sustained-release effect enters a bacterial cellulose membrane by using a dipping method to obtain a bacterial cellulose / medicament loading substance composite film (2). The sustained-release sticking film disclosed by the invention is good in adhesion, permeability and biocompatibility, large in medicament loading capacity, long in local effect time, capable of relieving pain, promoting wound healing and preventing wound infection. The sustained-release sticking film is suitable for oral traumas of oral ulcers, oral mucosal bites and the like.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a slow-release patch for treating oral ulcers. Background technique [0002] Oral ulcer is a common oral mucosal disease with complex etiology and easy recurrence. In daily life, oral ulcers caused by bites, burns, abrasions, scratches, etc. are more common. Once oral ulcers are formed, it not only affects the normal life and diet of patients, but sometimes even causes systemic diseases. For oral ulcers, clinical symptomatic treatment is mainly based on topical medications. Clinical medications include powders, ointments, films, injections and other dosage forms, but most of them directly affect the curative effect due to the short action time in the mouth. Such as powders such as traditional Chinese medicine Bingboran Powder, which must be applied to the affected area during use, and the medicine will be quickly lost with saliva; ointment is diffi...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/045A61K35/413A61K31/573A61K31/525A61K47/38A61P1/02
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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