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Preparation method of hydrogel patch substrate with gradient drug concentration

A technology of drug concentration and hydrogel, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problem of high initial investment.

Active Publication Date: 2013-06-05
薛巍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods all depend on the construction of certain equipment, and the initial investment is relatively high.

Method used

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  • Preparation method of hydrogel patch substrate with gradient drug concentration
  • Preparation method of hydrogel patch substrate with gradient drug concentration
  • Preparation method of hydrogel patch substrate with gradient drug concentration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] S1. Prepare a solution of sodium alginate (sodium alginate, product number S100126) with a concentration of 1%, add dry micron-sized hydroxyapatite powder (0.0137g hydroxyapatite per 10ml polysaccharide solution) and stir evenly until it becomes milky white The suspension is poured into a cylindrical mold of required shape, and the mold is put into a constant temperature and humidity chamber at 25°C to maintain a constant temperature;

[0031] S2. In the mould, add the mol ratio of calcium ion in the calcium salt to be the existing gluconolactone solution of 4:5, stir evenly,

[0032] S3. Put it into a centrifuge with temperature control at 25°C, centrifuge at a centrifugal speed of 4500r / min for 40min, and let stand to obtain a hydrogel.

[0033] S4. Remove the hydrogel and soak it in 25ug / ml methylene blue for 24 hours to complete drug gradient loading.

Embodiment 2

[0035] S1. Prepare a solution of sodium alginate (sodium alginate, product number S100126) with a concentration of 5%, add dry nano-scale calcium carbonate powder (0.0274g calcium carbonate per 10ml polysaccharide solution) and stir evenly, pour it into the required shape in the star mold;

[0036] S2. In the mould, add the freshly dissolved gluconolactone solution that the mol ratio of calcium ion in the calcium salt is 4:5, stir well,

[0037] S3. Put it into a centrifuge, centrifuge at a centrifugal speed of 2500r / min for 15min, and let it stand to obtain a hydrogel.

[0038] S4. The hydrogel was removed from the mold and soaked in 2 mg / ml colchicine for 18 hours to complete drug gradient loading.

Embodiment 3

[0040] S1. Prepare a natural polysaccharide solution of sodium carboxymethylcellulose (sodium carboxymethylcellulose, product number C104979) with a concentration of 3%, and add dry nano-sized hydroxyapatite powder (0.0274g hydroxyl apatite per 10ml polysaccharide solution) Apatite) Stir evenly, pour into the cuboid mold of required shape;

[0041] S2. In the mould, add the freshly dissolved gluconolactone solution that the mol ratio of calcium ion in the calcium salt is 4:5, stir well,

[0042] S3. Put it into a centrifuge, centrifuge at a centrifugal speed of 2500r / min for 30min, and let it stand to obtain a hydrogel.

[0043] S4. Remove the hydrogel and soak it in 2 mg / ml sodium sulfadiazine for 36 hours to complete drug gradient loading.

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Abstract

Provided is a preparation method of a hydrogel patch substrate with gradient drug concentration. The preparation method of the hydrogel patch substrate with the gradient drug concentration uses a centrifugation method to achieve cross linking agent gradient distribution, and therefore hydrogel of gradient cross linking is acquired. The design is ingenious, and the method is simple and practicable. Cross linking density gradient of hydrogel is regulated by temperature in the process of centrifugation, centrifugal speed, and centrifugal time. The higher temperature is, the higher the centrifugal speed is, and the longer the centrifugal time is, the larger the gradient is, and therefore concentration gradient load in the hydrogel of drugs is achieved. The preparation method of the hydrogel patch substrate with the gradient drug concentration is suitable for a transdermal drug delivery patch substrate as drug gradient slow release.

Description

technical field [0001] The invention relates to the field of hydrogels, in particular to a method for preparing a hydrogel patch matrix with gradient drug concentration. Background technique [0002] The hydrogel patch matrix is ​​a three-dimensional network water-filled cross-linked structure formed by mixing hydrophilic polymer materials, moisturizers, cross-linking agents, etc. with drugs. The solvent filled in it cannot flow freely, showing elasticity Or viscoelastic semi-solid properties. Drug molecules are uniformly dispersed or dissolved in the gel system, and will interact with solvents or polymer compounds to achieve high drug loading, sustained release, and controlled release. However, since the drug molecules are evenly distributed in the gel matrix, the release process is characterized by burst release at the initial stage, and the release concentration is too small to achieve the therapeutic effect in the later stage. The latest design of the gel matrix for ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K45/00A61K47/36A61K47/02C08J3/075C08L5/04C08L1/26C08K3/32C08K3/26C08K5/101
Inventor 张奕薛巍黄跃新谢莎莎刘宗华
Owner 薛巍
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