Ribavirin slow release nasal gel used for treating cold and preparation method of gel

Abstract

The invention belongs to the field of pharmacy, and relates to ribavirin slow release nasal gel used for treating cold and flu and a preparation method of the gel. The main components of the ribavirin slow release nasal gel comprise broad-spectrum and strong antiviral ribavirin in effective dose as a main drug and chitosan as the nasal gel matrix. The preparation method comprises the steps of: mixing the ribavirin with the chitosan to form sol gel; adding a preservative; then adjusting the pH value to 5.8-6.2 by using a pH adjusting agent; mixing uniformly; and sterilizing and packaging so as to finish the preparation. According to the invention, the water-soluble gel is adopted as a substrate to prepare the ribavirin nasal gel; the preparation process is simple; and the ribavirin slow release nasal gel remains in the nasal cavities for a long time and has a certain slow release effect, so that the biological utilization rate of the ribavirin slow release nasal gel is added, a good treatment function of the ribavirin slow release nasal gel is played, and low toxic and side effect is caused. The ribavirin slow release nasal gel used for treating cold has a relatively strong inhibition effect on the common infected influenza virus, and is convenient and comfortable to use.

Description

technical field [0001] The invention belongs to the field of medicine and relates to nasal drops, in particular to ribavirin nasal drops for treating colds and flu and a preparation method thereof. Background technique [0002] Ribavirin, also known as ribavirin or ribavirin, is a broad-spectrum antiviral drug. Ribavirin Nasal Drops has definite curative effect on preventing and treating nasal infection, and its clinical use in treating viral influenza has been included in the Chinese Pharmacopoeia. The preparation method of nasal drops is simple and the cost is low, but when administering the drug, the drug loss of nasal drops will cause individual differences, and due to the clearing function of nasal cilia, the retention time of the liquid in the nasal cavity is short, so to a certain extent Affect the absorption and efficacy of the drug. And nasal drops will inevitably stay in the pharynx in many processes, stimulate the pharyngeal mucosa, and symptoms such as xerostom...

AI Technical Summary

Problems solved by technology

The preparation method of nasal drops is simple and the cost is low, but during administration, the loss of nasal drops medicine will cause individual differences, and due to the clearing function of nasal cilia, the retention time of medicinal liquid in the nasal cavity is short, so to a certain extent Affect the absorption and efficacy of the drug

And in the process of many times, nasal drops will inevitably stay in the pharynx, stimulate the pharyngeal mucosa, and symptoms such as dry mouth, dry throat, and sore throat will reduce the patient's compliance

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