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Calcium and zinc gluconate liposome oral solution

A technology of calcium zinc gluconate and oral solution, which is applied in the field of liposome oral solution and its preparation method, calcium zinc gluconate liposome oral solution, and can solve the problem of no improvement, little difference in substance, and low bioavailability and other problems, to achieve the effect of long residence time, high encapsulation rate and high bioavailability

Inactive Publication Date: 2013-05-01
海南路易丹尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The prescription, preparation process and final dosage form disclosed in the above-mentioned patents are all different, but the essence is not much different; the poor stability and low bioavailability of the drug have not been improved

Method used

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  • Calcium and zinc gluconate liposome oral solution
  • Calcium and zinc gluconate liposome oral solution
  • Calcium and zinc gluconate liposome oral solution

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preparation example Construction

[0057] According to another aspect of the present invention, the preparation method of above-mentioned calcium zinc gluconate liposome oral solution is provided, the method may further comprise the steps:

[0058] (1) Stir and sonicate egg yolk lecithin, soybean sterol, phosphatidylglycerol and cholesterol in water for injection for 20 minutes, then perform gradient homogenization for 5 to 7 times under a pressure of 300bar-1000bar to obtain a lipid solution;

[0059] (2) Add calcium gluconate, zinc gluconate and lysine hydrochloride to the lipid solution prepared above, heat to 60°C, keep stirring and sonicate for 50 minutes;

[0060] (3) After dissolving trehalose in water for injection, pour the above solution into it, dilute to volume with water for injection, stir evenly, filter through a 0.45 μm microporous membrane, and fill to obtain calcium zinc gluconate liposome oral solution.

[0061] In the method according to the present invention, the gradient homogenization is ...

Embodiment 1

[0066] The preparation of embodiment 1 calcium zinc gluconate liposome oral solution

[0067] The raw materials used are as follows:

[0068]

[0069] The preparation process is as follows:

[0070] (1) Mix 120g of egg yolk lecithin, 20g of phosphatidylglycerol, 20g of soybean sterol and 20g of cholesterol in 800ml of water for injection and ultrasonically stir for 20min, then homogenize twice under 300bar pressure, twice under 800bar pressure, and finally 900bar Homogenize twice again to obtain a lipid solution;

[0071] (2) Add 60g of calcium gluconate, 3g of zinc gluconate and 10g of lysine hydrochloride to the lipid solution prepared above, heat to 60°C, keep stirring and ultrasonicate for 50min;

[0072] (3) Dissolve 55g of trehalose in an appropriate amount of water for injection, pour the above solution, add water for injection to 1000ml, stir evenly, filter with a 0.45μm microporous membrane, fill 10ml / bottle, and obtain 100 bottles of calcium zinc gluconate Lipo...

Embodiment 2

[0073] The preparation of embodiment 2 calcium zinc gluconate liposome oral solution

[0074] The raw materials used are as follows:

[0075]

[0076]

[0077] The preparation process is as follows:

[0078] (1) Mix 150g of egg yolk lecithin, 30g of phosphatidylglycerol, 30g of soybean sterol and 20g of cholesterol in 800ml of water for injection and ultrasonically stir for 20min, then homogenize once under 500bar pressure, 3 times under 500bar pressure, and finally 1000bar Homogenize twice again to obtain a lipid solution;

[0079] (2) Add 60g of calcium gluconate, 3g of zinc gluconate and 10g of lysine hydrochloride to the lipid solution prepared above, heat to 60°C, keep stirring and ultrasonicate for 50min;

[0080] (3) Dissolve 70g of trehalose in an appropriate amount of water for injection, pour the above solution, add water for injection to 1000ml, stir evenly, filter with a 0.45μm microporous membrane, fill 10ml / bottle, and obtain 100 bottles of calcium zinc g...

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Abstract

The invention relates to a calcium and zinc gluconate liposome oral solution and its preparation method. The liposome oral solution is prepared from specific weight proportions of calcium gluconate, zinc gluconate, lysine hydrochloride, egg yolk lecithin, soy sterol, phosphatidyl glycerol, cholesterol and mycose. The liposome oral solution has the advantages of good preparation stability, maintenance of the good entrapment rate of liposome after long-term storage, improvement of the preparation product quality, increase of the retention time of medicines in the systematic circulation, improvement of the biological availabilities of the medicines, obvious improvement of the curative effect, simple preparation method and suitableness for the industrialized production.

Description

technical field [0001] The invention relates to a liposome oral solution and a preparation method thereof, in particular to a calcium zinc gluconate liposome oral solution and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] The blood calcium of normal people is maintained at 2.18-2.63 mmol / L (9-11 mg / dL). If it is lower than this range, it is considered as calcium deficiency. Calcium deficiency in children: difficult to fall asleep, difficult to enter deep sleep, crying after falling asleep, easy to wake up, hyperhidrosis after falling asleep; paroxysmal abdominal pain, diarrhea, cramps, sternum pain, "X"-shaped legs, "O"-shaped legs , chicken breasts, gray nails or white marks; anorexia, partial eclipse; daytime irritability, restlessness; delayed mental development, late speech; late toddler; Zigzag; thinning hair; poor health, easy to catch colds, etc. When teenagers lack calcium: they will fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/191A61K9/127A61K47/36A61P3/14A61P3/12A61P3/02
Inventor 王平
Owner 海南路易丹尼生物科技有限公司
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