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Iron-based composite material used for full-degradation cardiovascular support and preparation method thereof

An iron-based composite material, medical technology, applied in medical science, surgery, coating and other directions, can solve the problems of difficult to control the formation and uniform distribution of metal mesophase, accelerate the effect of pure iron corrosion rate, accelerate corrosion, etc., to avoid Late thrombosis, improved mechanical strength, uniform corrosion effect

Inactive Publication Date: 2013-03-13
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] From the perspective of materials science, there are two main methods to improve the corrosion rate and corrosion mode of pure iron: one is to add some alloying elements of non-noble metals to make the iron matrix more prone to corrosion, but studies have confirmed that this method is very effective for accelerating the corrosion of pure iron. The corrosion rate effect is not ideal; the other is to form a fine and uniformly dispersed metal interphase by adding noble metal alloying elements, which acts as an anode and iron matrix to form galvanic corrosion, which can accelerate corrosion. However, traditional casting technology, The formation and uniform distribution of metallic mesophases are difficult to control

Method used

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  • Iron-based composite material used for full-degradation cardiovascular support and preparation method thereof
  • Iron-based composite material used for full-degradation cardiovascular support and preparation method thereof
  • Iron-based composite material used for full-degradation cardiovascular support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, preparation Fe-W / Fe 2 o 3 / FeS composite material

[0043] Pure Fe powder (99.9wt.%, particle size 100nm~100μm), W powder (99.8%, particle size 100nm~100μm), Fe 2 o 3 FeS powder (99.0%, particle size 100nm~100μm) and FeS powder (99.0%, particle size 100nm~100μm) were used as test raw materials, and were prepared according to the secondary phase X content (mass) of 2% and 5%, respectively.

[0044] After being manually mixed in a mortar, it was mixed for 5 minutes at a speed of 2000 rpm in a mixer. Put the mixed powder in a graphite mold, and in a vacuum environment, use discharge plasma sintering technology to sinter at 950 ° C under a pressure of 40 MPa, hold for 5 minutes, and then cool to room temperature to obtain iron-based composite materials: respectively Fe-2W, Fe-5W, Fe-2Fe 2 o 3 , Fe-5Fe 2 o 3 , Fe-2FeS and Fe-5FeS.

[0045] The metallographic microstructure of the iron-based composite material prepared in this example is as follows: fi...

Embodiment 2

[0046] Embodiment 2, preparation Fe-CNT composite material

[0047] Using pure Fe powder and CNT powder (diameter 10-30nm, length 1-10μm) as raw materials, according to the ratio of the added phase content of 0.5% and 1% respectively, using ethanol as a dispersant, using a stainless steel ball with a diameter of 5mm in the After ball milling and mixing for 8 hours at a rotational speed of 80 r / min, it was dried, and then sintered with the same spark plasma sintering parameters as in Example 1 to obtain a Fe-CNT composite material sample.

[0048] The metallographic microstructure of the Fe-CNT composite material prepared in this embodiment is as follows: figure 1 It can be seen from the figure that the CNTs are uniformly distributed in the iron matrix after being mixed and sintered by ball milling, and the addition of CNTs also significantly reduces the grain size of the iron matrix.

Embodiment 3

[0049] Embodiment 3, room temperature compression performance of iron-based composite material

[0050] The composite materials prepared in Example 1 and Example 2 were prepared according to the compression test standard GB / T 7314-2005 to prepare compression samples for compression performance testing. The sample size was Φ2×5mm, and the compression strain rate was 2×10 -4 / s, since the material is a plastic material, the compressive strength is the stress value when the compressive strain is 40%.

[0051] The compressive mechanical properties of the iron-based composite material prepared in embodiment 1 and embodiment 2 are as follows: figure 2 As shown, cast (As-cast) pure iron and spark plasma sintered (SPS) pure iron are used for comparison.

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Abstract

The invention discloses an iron-based composite material used for a full-degradation cardiovascular support and a preparation method thereof. The iron-based composite material comprises Fe and any one of W, Fe2O3, FeS and carbon nano tube, wherein the content of any one of W, Fe2O3, FeS and carbon nano tube is 0-10% and more than 0% in the iron-based composite material in percent by weight. The preparation method of the iron-based composite material comprises the following steps of: mixing iron powder with any one of tungsten powder, Fe2O3 powder, FeS powder and carbon nano tube powder, then carrying out spark plasma sintering or sintering by virtue of powder metallurgy, and cooling, so that the iron-based composite material is obtained. The iron-based composite material used for full-degradation cardiovascular support disclosed by the invention overcomes the defects of the traditional inert metal support such as late thrombosis and restenosis; and a secondary phase harmless to a human body is selected as a strengthening phase of the composite material, so that corrosion rate of an iron base in a body fluid environment is increased, and corrosion of the iron base is more uniform.

Description

technical field [0001] The invention relates to an iron-based composite material for a fully degradable cardiovascular stent and a preparation method thereof. Background technique [0002] At present, the clinically used cardiovascular stent materials are mainly metal materials, including 316L stainless steel, Ti and Ni-Ti alloys, Co-Cr alloys, Pt-Ir alloys, and metal Ta. However, these stent materials are all biologically inert materials and are not biodegradable in vivo. After implantation, they will exist in the body as foreign bodies for a long time, and there is a risk of vascular restenosis and late thrombosis. At the same time, long-term antiplatelet therapy is required. In view of the above reasons, the development of biodegradable cardiovascular stent materials is the development trend of cardiovascular stents. [0003] Domestic and foreign research on degradable cardiovascular stent materials focuses on magnesium alloys and pure iron. However, magnesium alloys ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/16
Inventor 郑玉峰程健
Owner PEKING UNIV
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