Porotic bone scaffold and preparation method thereof

Abstract

The invention provides a porotic bone scaffold, which is formed by biological activity additives, degradable metal, degradable inorganic substances and degradable polymers. The porotic bone scaffold is in a shape of a cuboid, a cylinder, a cube or a cylinder with a cross section being diamond-shaped; a plurality of holes is formed in the porotic bone scaffold; the connection rate of the holes is greater than 97 percent; a plurality of micropores is formed in hole walls of the holes; a pore diameter of each hole is 100-800 mum; a pore diameter of each micropore is 5-100 mum, and a hole depth of each micropore is 1-50 mum; and the porosity of the porotic bone scaffold is 60-95 percent. Due to a porotic structure, the adhesion of bone tissue cells and the transmission of nutrients are favored, the cells can be effectively fixed so as to be differentiated and proliferated, a favorable growing environment is provided for cell growth, and the repair of defected bone tissue is favored to be realized. The invention also provides a preparation method of the porotic bone scaffold.

Description

technical field [0001] The invention relates to the technical field of biomedical tissue engineering, in particular to a porous bone support and a preparation method thereof. Background technique [0002] With the development of society, bone defects, especially long-segment bone defects, caused by population aging, trauma, bone tumors, etc., have become a thorny problem in orthopedics clinical practice. Due to the lack of suitable treatment methods, the number of disabled people is increasing year by year, which has a serious impact on social stability and people's quality of life. Traditional biological treatment methods for bone defect treatment include autologous bone graft, cancellous bone allograft, fibula and iliac crest with vascular grafts, and other bone graft methods, etc., but there are donor shortages, rejection reactions, complications at the donor site, and surgical costs. Defects such as long cycle time. Bone tissue engineering is to plant human cells into ...

AI Technical Summary

Problems solved by technology

The above methods all have different defects and limitations

For example, the particle precipitation method has shortcomings such as irregular, too small, and uncontrollable pore communication channels, which are not conducive to cell migration; the porogen method has porogen residues that cause cytotoxicity; the scaffold prepared by the high-pressure gas foaming method is too small. Or the pores are not connected, which is not conducive to cell adhesion and growth; the mechanical properties of the scaffold prepared by electrospinning technology are low, and the controllability of the above method is low, making it difficult for the prepared porous bone scaffold to meet the requirements of pore size and porosity. , Requirements for the specific surface area of ​​the hole wall

Images