Resveratrol nanoscale dispersoid and preparation method thereof

A nano-dispersion, resveratrol technology, applied in the directions of hydroxyl compound active ingredients, powder delivery, metabolic diseases, etc., can solve the problems of low stability and low solubility of resveratrol, and solve the problem of organic solvent residues, Good stability and fluidity, the effect of reducing production costs

Active Publication Date: 2012-08-01
BEIJING WINSUNNY PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dispersion prepared by the method of the present invention can be quickly dispersed in cold water to form a transparent liquid. The present invention solves the problems of low stability and low solubility of resveratrol in water, and is beneficial to improve the bioavailability of resveratrol

Method used

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  • Resveratrol nanoscale dispersoid and preparation method thereof
  • Resveratrol nanoscale dispersoid and preparation method thereof
  • Resveratrol nanoscale dispersoid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 2.0 g of the resveratrol crude drug and dissolve it in 60 ml of absolute ethanol at room temperature to prepare a resveratrol solution. Weigh 10.0 g of hypromellose and 10.0 g of maltitol, and dissolve them in 1200 ml of deionized water at room temperature to obtain an aqueous solution of the auxiliary material. Add the resveratrol solution into the auxiliary material aqueous solution, stir with a magnetic stirrer, and obtain a light blue transparent mixed solution after two minutes.

[0029] The transparent mixed liquid was spray-dried, and the operating parameters were: air inlet temperature 105° C., air outlet temperature 55° C., feed flow rate 12.5 ml / min, and the resveratrol nano-dispersion was obtained. This dispersion was dispersed in cold water to obtain a light blue transparent aqueous dispersion.

Embodiment 2

[0031] Weigh 2.5g of the resveratrol crude drug and dissolve it in 50ml of anhydrous methanol at room temperature to prepare a resveratrol solution. Weigh 7.5g of methylcellulose, 7.5g of water-soluble vitamins, and 7.5g of mannitol, and dissolve them in 1000ml of deionized water at room temperature to obtain an aqueous solution of the auxiliary material. Add the resveratrol solution into the aqueous solution of the auxiliary materials, stir with a high-speed stirrer, and the speed of the stirring paddle is 7000 rpm, and obtain a light blue transparent mixed solution after two minutes.

[0032] The transparent mixed liquid was spray-dried, and the operating parameters were: air inlet temperature 110° C., air outlet temperature 56° C., feed flow rate 15.0 ml / min, and the resveratrol nano-dispersion was obtained. This dispersion was dispersed in cold water to obtain a light blue transparent aqueous dispersion.

Embodiment 3

[0034] Weigh 1.0 g of the resveratrol crude drug and dissolve it in 40 ml of acetone at room temperature to prepare a resveratrol solution. Weigh 2.0g of polyethylene glycol 4000, 3.0g of polyoxyethylene hydrogenated castor, and 5.0g of lactose, and dissolve them in 800ml of deionized water at room temperature to obtain an aqueous solution of auxiliary materials. Add the resveratrol solution into the auxiliary material aqueous solution, stir with a magnetic stirrer, and obtain a light blue transparent mixed solution after two minutes.

[0035] The transparent mixed liquid was spray-dried, and the operating parameters were: air inlet temperature 115° C., air outlet temperature 58° C., feed flow rate 10.0 ml / min, and the resveratrol nano-dispersion was obtained. This dispersion was dispersed in cold water to obtain a light blue transparent aqueous dispersion.

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Abstract

The invention relates to resveratrol nanoscale dispersoid and a preparation method thereof. The resveratrol nanoscale dispersoid comprises: by mass, 1 to 20% of resveratrol as an active component, 40 to 80% of auxiliary materials and 5 to 40% of additives. The resveratrol nanoscale dispersoid is dispersed in cold water thereby forming a transparent solution, wherein resveratrol particle sizes are less than 150 nanometers. The preparation method comprises the following steps of dissolving resveratrol in a water-soluble organic solvent to obtain a resveratrol solution, dissolving certain amounts of the auxiliary materials and the additives in water to obtain an aqueous solution containing the auxiliary materials and the additives, adding the resveratrol solution into the aqueous solution containing the auxiliary materials and the additives to obtain a transparent mixed solution, and carrying out spray drying of the transparent mixed solution to obtain the resveratrol nanoscale dispersoid. The preparation method of the resveratrol nanoscale dispersoid having high stability and good water dispersibility can be used in the fields of drugs, health products, foods and cosmetics.

Description

technical field [0001] The invention relates to a resveratrol nano-dispersion and a preparation method thereof, belonging to the field of pharmaceuticals. technical background [0002] In 1924, resveratrol was discovered; in 1940, Japanese scholars obtained resveratrol from the root of veratrol for the first time; in 1963, Nonomura et al pointed out that this substance is an effective ingredient for treating inflammation, lipid metabolism and heart disease; in 1992 Resveratrol was first discovered in commercial wine, and in the same year, the scientific community further confirmed that wine is rich in resveratrol; research results in recent years have shown that resveratrol has anti-oxidation, blood lipid regulation, anti-cancer and other health benefits Function; In 1998, when American Al Mindell compiled the "Anti-aging Holy Book", resveratrol was listed as one of the "100 most effective anti-aging substances". [0003] The chemical name of resveratrol is 3,4',5,-trihydro...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/05A61P3/06A61P35/00A61P39/06
Inventor 陈建峰张笑萍乐园王洁欣黄河耿玉先张志兵朱文珍
Owner BEIJING WINSUNNY PHARMA CO LTD
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