Polyethylene glycol dendritic polymers and preparation method thereof
A technology based on polyethylene glycol and polyethylene glycol, which is applied in the chemical industry, can solve the problems of limited combined use, waste of package load function, and non-utilization of hydrophobic space, and achieves the effect of mild reaction conditions and low cost
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Embodiment 1
[0038] Using PEG200, ethyl acrylate (abbreviation: EA) and ethylenediamine as raw materials, methanol as the catalyst and solvent for the addition reaction to prepare PEG dendrimers, the preparation method is as follows:
[0039] (1) Preparation of branch unit: Dissolve 2.00g of PEG200 in 20mL of tetrahydrofuran (abbreviation: THF), add 6.00g of EA, after stirring evenly, add 100mg of Novozyme 435, and react for 48h under stirring at 50°C. After the reaction, filter The enzyme was removed, the filtrate was distilled under reduced pressure to remove the solvent, excess EA and by-product ethanol, the remaining liquid was separated by column chromatography, and the eluent of petroleum ether / ethyl acetate was eluted to obtain the product as PEG200 diacrylate, pale yellow and transparent Liquid, the average molecular weight is 308g / mol;
[0040](2) Preparation of the first generation polyethylene glycol dendrimer (G1): Dissolve 3.08 g of PEG200 diacrylate in 10 mL of methanol, diss...
Embodiment 2
[0050] Using PEG400, methyl acrylate (referred to as: MA) and 1,3-propanediamine (hereinafter referred to as: propylene diamine) as raw materials, potassium tert-butoxide as the catalyst for the addition reaction to prepare PEG dendrimers, the preparation method is as follows :
[0051] (1) Preparation of branch unit: Dissolve 4.00g PEG400 in 25mL THF, add 5.16g MA, stir evenly, add 250mg Novozyme 435, and react at 50°C for 48h under stirring conditions. After the reaction, the enzyme is removed by filtration, and the filtrate is reduced The solvent, excess MA and by-product methanol were removed by pressure distillation, the remaining liquid was separated by column chromatography, and the eluent of petroleum ether / ethyl acetate was eluted to obtain the product PEG400 diacrylate, pale yellow transparent liquid, and the average molecular weight was 508g / mol;
[0052] (2) Preparation of the first generation polyethylene glycol dendrimer (G1): Dissolve 5.08g PEG400 diacrylate in...
Embodiment 3
[0062] Using PEG600, vinyl acrylate (abbreviation: VA) and 1,4-butanediamine (hereinafter referred to as: butanediamine) as raw materials, triethylamine as the catalyst for the addition reaction to prepare PEG dendrimers, the preparation method is as follows:
[0063](1) Preparation of branch unit: Dissolve 6.00g PEG600 in 25mL THF, add 5.88g VA, stir evenly, add 250mg Novozyme 435, and react at 50°C for 48h. The solvent, excess VA and by-product acetaldehyde were distilled off, the remaining liquid was separated by column chromatography, and the eluent of petroleum ether / ethyl acetate was eluted to obtain the product PEG600 diacrylate, pale yellow transparent liquid with an average molecular weight is 708g / mol;
[0064] (2) Preparation of the first generation polyethylene glycol dendrimer (G1): Dissolve 7.08g PEG600 diacrylate in 10mL THF, take 0.088g butanediamine and 0.404g triethylamine and dissolve in 1mL THF, stirring conditions The THF solution of butanediamine was slo...
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