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Separate type water suspension medicament of fluticasone propionate containing auxiliary materials for treating skin disease

A technology for fluticasone propionate and skin diseases, which can be applied to skin diseases, drug combinations, and pharmaceutical formulations, etc. It can solve the problems of inability to guarantee the Ostwald ripening of microparticle suspensions and particle instability, and achieve waste reduction and convenience. The effect of using

Inactive Publication Date: 2012-07-04
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] How to solve the problem of particle instability in microparticle suspensions has always been one of the problems that need to be solved in pharmacy, but no matter by adding excipients or improving the particle structure, there is no guarantee that microparticle suspensions will not appear Ostwald particles. Aging phenomena, especially skin suspensions that are used repeatedly, are more likely to have the above problems

Method used

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  • Separate type water suspension medicament of fluticasone propionate containing auxiliary materials for treating skin disease
  • Separate type water suspension medicament of fluticasone propionate containing auxiliary materials for treating skin disease

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preparation example Construction

[0030] 1. Preparation of drug particles for transdermal absorption

[0031] The capsules packed with pharmaceutical particles obtained in Examples 1 to 10 are vegetable capsules, and the capsules are sealed and packaged in glass bottles after being packed.

Embodiment 1

[0033] 0.2g of fluticasone propionate was dissolved in ethanol, filtered, sterilized, the filtrate was spray-dried, micronized to make the particle size 3μm, and mixed with 1g sodium lauroyl sarcosinate and 1.5g crystalline lactose with a particle size of 30μm. After passing through a 200-mesh sieve 3 times and mixing them, they are divided into No. 2 capsules. Each capsule contains 2 mg of fluticasone propionate. The electron microscope observed that the drug particles were spherical.

[0034] The process conditions are: inlet temperature is 100°C, outlet temperature is 70°C, air flow rate is 90%, nozzle outlet inner diameter is 0.1cm, nozzle air flow rate is 800ml / min, sampling speed is 50mL / h

Embodiment 2

[0036] Dissolve 1g of fluticasone propionate in ethanol. After filtering, the filtrate is spray-dried and micronized to a particle size of 3μm. It is mixed with 12g sodium lauroyl glutamate and 15g crystalline lactose with a particle size of 30μm. Sterilize after mixing and distribute into No. 2 capsules. Each capsule contains 1mg fluticasone propionate. The electron microscope observed that the particles were spherical.

[0037] The process conditions are: the inlet temperature is 105°C, the outlet temperature is 70°C, the air flow rate is 90%, the nozzle outlet inner diameter is 0.1cm, the nozzle air flow rate is 800ml / min, and the sampling speed is 50mL / h.

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Abstract

The invention relates to a separate type water suspension medicament of fluticasone propionate containing auxiliary materials for treating skin disease, composed of separately packed fluticasone propionate and separately packed water, wherein the fluticasone propionate contains one or more kinds of pharmaceutical auxiliary materials for skin, is insoluble in water and has a D90 particle size of 0.1-10mu m.

Description

Technical field: [0001] The present invention relates to a dermatological medicine, which is composed of individually packaged fluticasone propionate containing one or several dermal pharmaceutical excipients and individually packaged water. Background technique: [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are caused by an allergic reaction caused by a certain allergen. [0003] In the skin drug delivery system, the skin is the main barrier for drugs to enter the body. Studies have found that only a few drugs have excellent skin permeability, and most drugs cannot easily pass through the effective and selective barrier of human skin. Drugs with higher solubility can penetrate the epidermis more easily. In the treatment of skin diseases, the most common type of preparation is transdermal drug delivery, transdermal thrapeutic systems or transdermal drug delivery systems (transdermal thrapeutic systems, transdermal drug delivery s...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K9/10A61P17/00A61P17/08A61P37/08
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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