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Suspension dispersible tablets and preparation method

A dispersible tablet and suspension technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of children's poor drug compliance, poor control of dosage, and inconvenient carrying, etc., to improve biological Utilization, convenient transportation and carrying, and good patient compliance

Active Publication Date: 2012-05-30
HAINAN PULIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The advantages of dry suspension are that the drug has a wide distribution area in the gastrointestinal tract, fast absorption, and high bioavailability, but it is inconvenient to carry and the dosage is not easy to control, especially for children.
Dispersible tablets have the advantages of accurate dose control, and are more convenient to carry, transport, and take. However, the bioavailability of the drug is not as high as that of the dry suspension, and children’s drug compliance is poor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: prepare 200 cefixime suspension dispersible tablets

[0026] Prescription: Cefixime 28.2g sucrose 35g

[0027] Xanthan gum 2.01g Sodium carboxymethyl cellulose 0.5g

[0028] Microcrystalline cellulose 23.8g Crospovidone 5.0g

[0029] Aspartame 2.0g Strawberry Powder Flavor 2.0g

[0030] Micropowder silica gel 0.5g Magnesium stearate 1.0g

[0031] Preparation:

[0032] (1), cefixime, sucrose, and sodium carboxymethyl cellulose were sieved and mixed evenly, then added purified water, granulated with a stirring granulator, the wet granules were dried in an oven, and the dry granules were passed through a 30-mesh sieve for granulation, Add xanthan gum and mix evenly to obtain suspended particles;

[0033] (2) Mix the suspended granules with other excipients in the prescription evenly to obtain the mixed powder.

[0034] (3) Compress the mixed powder into tablets to obtain.

[0035] The tablet weighs about 500 mg and has a hardnes...

Embodiment 2

[0038] Embodiment 2: prepare 1000 desloratadine suspension dispersible tablets

[0039] prescription:

[0040] Desloratadine 7.9g Precipitated silica 0.1g

[0041] Eudragit E100 2.5g Mannitol 87.5g

[0042] Lactose 87.5g xanthan gum 5.25g

[0043] Sodium Carboxymethyl Cellulose 3.5g Microcrystalline Cellulose 105g

[0044] Crospovidone 21g Aspartame 10.5g

[0045] Sweet orange essence 12.25g Micropowder silica gel 3.5g

[0046] Magnesium stearate 3.5g

[0047] Preparation:

[0048] (1), first prepare desloratadine coated granules with desloratadine, precipitated silicon dioxide and Eudragit E100;

[0049] (2) Sieve mannitol, lactose, and sodium carboxymethyl cellulose and mix evenly, then add purified water, in a stirring granulator, dry the wet granules in an oven, pass through a 30-mesh sieve for granulation, and then add xanthan The glue is mixed evenly to obtain suspension granules;

[0050] (3) Mix the above-mentioned suspension granules with the remaining excipi...

Embodiment 3

[0052] Embodiment 3: prepare 1000 azithromycin pellet capsules

[0053] Take the following prescription::

[0054] Azithromycin 100g Acrylic resin IV 35g

[0055] Mannitol 150g Lactose 200g

[0056] Xanthan gum 7.5g Sodium carboxymethyl cellulose 5g

[0057] Microcrystalline Cellulose 150g Crospovidone 30g

[0058] Aspartame 15g Sweet Orange Flavor 17.5g

[0059] Micronized silica gel 5g Magnesium stearate 5g

[0060] Preparation Process:

[0061] (1), azithromycin is coated with acrylic resin IV to obtain azithromycin coated granules;

[0062] (2), sieve and mix mannitol, lactose, and sodium carboxymethyl cellulose, then add purified water, granulate in a stirring granulator, dry the wet granules in an oven, pass through a 30-mesh sieve for granulation, and then add yellow The raw gum is mixed evenly to obtain suspension granules;

[0063](3) Mix the above-mentioned azithromycin coated granules with the suspension granules and the remaining excipients in the prescript...

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Abstract

The invention relates to dosage forms of medicines, and discloses suspension dispersible tablets which at least comprise (1) an effective active component, (2) an excipient mixture at least comprising a disintegrating agent, and (3) suspension particles comprising a filling agent, a suspending agent and an adhesive. The suspension dispersible tablets have advantages as suspensions, such as wide distribution in gastrointestinal tracts and high bioavailability, and have advantages as tablets, such as appropriate hardness, easy transportation, easy carrying, and accurate dosage controlling.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a new dosage form suspension dispersible tablet and a preparation method thereof. Background technique [0002] According to the provisions of the Chinese Pharmacopoeia, dry suspensions are powders or granules made of insoluble solid drugs and suitable auxiliary materials, which can be dispersed into suspensions and taken orally by shaking before use. Dispersible tablets are tablets that disintegrate rapidly and disperse uniformly in water. Existing dispersible tablet is exactly to be made by compressing the tablet after mixing medicine and adjuvant at present, only meets the relevant quality standard of tablet. The quality of the suspension dispersible tablet prepared by the present invention, in addition to meeting the relevant requirements under the tablet item, also meets the relevant quality indicators of the Chinese Pharmacopoeia about dry suspensions, including ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61K31/546A61K31/7052A61K31/4545A61K31/196
Inventor 范敏华徐海刘华周学来
Owner HAINAN PULIN PHARMA
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