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Preparation method of a drug release system with water-insoluble protein powder as drug carrier

A non-water-soluble, protein powder technology, applied in peptide/protein ingredients, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as drug inability

Inactive Publication Date: 2012-05-09
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above existing problems, the object of the present invention is to provide a method for preparing a drug release system relying on water-insoluble protein powder as a drug carrier. The preparation method of the drug release system relies on water-insoluble The protein powder is the drug carrier, and the non-water-soluble protein powder forms a continuous water channel inside the polymer, which provides a path for the complete release of the drug and completely solves the problem that the drug cannot be released from the inside of the polymer.

Method used

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  • Preparation method of a drug release system with water-insoluble protein powder as drug carrier
  • Preparation method of a drug release system with water-insoluble protein powder as drug carrier

Examples

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specific Embodiment 1

[0036] Boil the obtained silk in a Na2CO3 solution with a mass fraction of 1% and a bath ratio of 1:20 for 3 hours, wash it with distilled water at 50°C after complete degumming, and dry it to obtain silk fiber.

[0037] Firstly, the silk fibroin fiber is beaten into a short pile of about 3mm on a rotary blade, and then ground. After grinding, water-insoluble silk fibroin powder with a particle size below 100 μm is obtained.

[0038] 1g of heparin sodium was dissolved in 19g of distilled water to obtain a drug concentration of 5% by mass. After uniform stirring, 3.3 g of water-insoluble silk fibroin powder were dispersed therein, wherein the mass ratio of water-insoluble silk fibroin powder to heparin sodium drug aqueous solution was 1:6. The mixture of the silk fibroin powder and the drug is placed and soaked for 1 hour at 25 degrees Celsius. Then dry the mixture of the silk fibroin powder and the aqueous drug solution, place it in an oven at 30° C. and heat it until all th...

specific Embodiment 2

[0040] Boil the obtained silk in a Na2CO3 solution with a mass fraction of 1% and a bath ratio of 1:20 for 3 hours, wash it with distilled water at 50°C after complete degumming, and dry it to obtain silk fiber.

[0041] Firstly, the silk fibroin fiber is beaten into a short pile of about 3mm on a rotary blade, and then ground. After grinding, water-insoluble silk fibroin powder with a particle size below 100 μm is obtained.

[0042] 2g heparin sodium is dissolved in 18g distilled water, and the medicine mass percentage that obtains medicine concentration is 10%. After uniform stirring, 3.3 g of water-insoluble silk fibroin powder were dispersed therein, wherein the mass ratio of water-insoluble silk fibroin powder to heparin sodium drug aqueous solution was 1:6. The mixture of the silk fibroin powder and the drug was placed and soaked for 2 hours at 25°C. Then dry the mixture of the silk fibroin powder and the aqueous drug solution, place it in an oven at 40 degrees centigr...

specific Embodiment 3

[0044] Firstly, the clean wool fibers are beaten into a short pile of about 3mm on a rotary blade, and then ground. After grinding, a water-insoluble wool powder with a particle size below 100 μm is obtained.

[0045] 4g heparin sodium is dissolved in 16g distilled water, and the medicine mass percentage that obtains medicine concentration is 20%. After uniform stirring, 3.3 g of water-insoluble wool powder was dispersed therein, wherein the mass ratio of water-insoluble wool powder to heparin sodium drug aqueous solution was 1:6. The mixture of wool powder and medicine was placed and soaked for 2.5 hours at 25 degrees Celsius. Then the mixture of the wool powder and the aqueous drug solution is dried, placed in an oven at 40 degrees Celsius and heated until all the distilled water is removed. The dried non-water-soluble wool powder is put into a universal high-speed pulverizer for pulverization, and the pulverization time is 6 minutes.

[0046] 15g of medical polyglycolide...

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Abstract

The invention aims to provide a preparation method of a drug release system which depends on a water-insoluble protein powder as a drug carrier. According to the preparation method of the drug release system, the water-insoluble protein powder with good water absorption is used as a drug carrier, and simultaneously the water-insoluble protein powder forms a continuous water channel in a polymer so as to provide a channel for complete drug release and thoroughly solve the problem that drugs can not be released from the inside of the polymer. The preparation method has advantages of simple technology and fast preparation speed. As the water-insoluble protein powder has good biocompatibility and is nontoxic and harmless, the prepared drug release system also has good biocompatibility and is nontoxic and harmless. Through the water channel formed by the water-insoluble protein powder during the application process, the drug release speed can be effectively controlled, and the carried drug can be completely released, thus reaching better curative effects and avoiding drug waste.

Description

technical field [0001] The invention relates to a preparation method of a drug release system relying on water-insoluble protein powder as a drug carrier, belonging to the field of drugs and medical devices. Background technique [0002] Biomedical materials are mostly polymer materials. These biopolymer materials need to be in direct contact with blood. Therefore, in addition to the necessary mechanical properties and biological functions, biopolymer materials must also have excellent blood compatibility and tissue compatibility. Capacitance. Therefore, how to improve and enhance the biocompatibility, hemocompatibility and anticoagulation performance of materials is a key issue in basic research and material preparation. At present, there are two main methods to improve the biocompatibility, hemocompatibility and anticoagulant performance of polymer materials; one is to graft some drugs on the surface of polymer materials by chemical grafting, so as to improve the Biocomp...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K31/727A61K31/616A61K38/58A61K31/436A61K31/573A61K31/337A61K39/395
Inventor 徐卫林杨红军王珍珍崔卫钢李文斌
Owner WUHAN TEXTILE UNIV
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