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Blumea riparia tablet and preparation process thereof

A kind of Gui Ai Na Xiang tablet, the technology of preparation process, applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, plant raw materials, etc. Problems such as large equipment investment, to achieve the effect of improving bioavailability, simple preparation process, and short process flow

Active Publication Date: 2013-09-04
GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The embodiment of the present invention provides a kind of Diangui Ainaxiang tablet, which aims to solve the problem of large dosage and slow drug effect in the prior art of Diangui Ainaxiang preparation; and provides a preparation process of Diangui Ainaxiang tablet, which aims at In order to solve the problems of low extraction rate of Diangui Ainaxiang, large equipment investment in the production process, long production process, large equipment energy consumption and equipment cleaning water consumption, easy explosion of alcohol as a wetting agent in the production process, and the need for explosion-proof, After the material is granulated, it needs to be dried at high temperature, the heating time is long, and the photosensitivity and heat-sensitivity components are easy to be lost.

Method used

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  • Blumea riparia tablet and preparation process thereof
  • Blumea riparia tablet and preparation process thereof
  • Blumea riparia tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh 3500g of Diangui Ainaxiang, add 12 times the weight of 0.1% acetic acid water to decoct for 1.5 hours, filter, add 15 times the weight of water to the filter residue and decoct for 1.5 hours, filter, combine the two decoctions, and concentrate the filtrate To 60°C clear paste with a relative density of about 1.05, add acetic acid to adjust the pH value to 4.0, put it on a DA-201 macroporous resin column, the weight ratio of macroporous resin to clear paste is 10:3.7, and then use 1 times the amount of water in turn Elute with 3 times the amount of 30%, 55% and 80% ethanol at a speed of 4BV / h, collect and combine the ethanol eluents of various concentrations, concentrate, dry, control the moisture content to be less than 3%, and crush to obtain the extract of Artemisia argyi Dry cream powder. Take by weighing 70 grams of silicified microcrystalline cellulose, 10 grams of mannitol and mix evenly with the prepared dry paste powder of the extract of osmanthus osmanthu...

Embodiment 2

[0030] Weigh 3000g of Diangui Ainaxiang, add 11 times the weight of 0.05% acetic acid water to decoct for 2 hours, filter, add 20 times the weight of the filter residue to decoct for 1 hour, filter, combine the two decoctions, and concentrate the filtrate To 60°C clear paste with a relative density of about 1.05, add acetic acid to adjust the pH value to 3.0, put it on a DA-201 macroporous resin column, the weight ratio of macroporous resin to clear paste is 10:3.5, and then use 1 times the amount of water in turn Elute with 3 times the amount of 30%, 55% and 80% ethanol at a speed of 4BV / h, collect and combine the ethanol eluents of various concentrations, concentrate, dry, control the moisture content to be less than 3%, and crush to obtain the extract of Artemisia argyi Dry cream powder. Take by weighing 30 grams of silicified microcrystalline cellulose, 5 grams of mannitol and mix them evenly with the prepared dry paste powder of the osmanthus osmanthus extract, adjust the...

Embodiment 3

[0032] Weigh 3800g of Diangui Ainaxiang, add 14 times the weight of 0.2% acetic acid water to decoct for 1 hour, filter, add 9 times the weight of water to the filter residue and decoct for 2 hours, filter, combine the two decoctions, and concentrate the filtrate To 60°C clear paste with a relative density of about 1.05, add acetic acid to adjust the pH value to 5.0, put it on a DA-201 macroporous resin column, the weight ratio of macroporous resin to clear paste is 10:6.5, and then use 1 times the amount of water in turn Elute with 3 times the amount of 30%, 55% and 80% ethanol at a speed of 4BV / h, collect and combine the ethanol eluents of various concentrations, concentrate, dry, control the moisture content to be less than 3%, and crush to obtain the extract of Artemisia argyi Dry cream powder. Take by weighing 100 grams of silicified microcrystalline cellulose, 20 grams of mannitol and mix evenly with the prepared dry paste powder of the extract of osmanthus osmanthus, ad...

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Abstract

The invention provides a blumea riparia tablet, which comprises the following components: therapeutically effective amount of blumea riparia extractive, silicified microcrystalline cellulose, mannitol, polyacrylic acid resin IV, titanium dioxide, sodium carboxymethyl starch, colloidal silicon dioxide and glyceryl distearate. The invention also provides a preparation process of the blumea riparia tablet. With the same medicinal material content, the blumea riparia tablet can reduce the everyday doses of a patient. In the invention, the auxiliary materials are reasonably selected and prepared, so that the coordination role of components in the auxiliary materials can be fully played. The preparation process is simple, the process flow is short, and the production is easy.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a Diangui Ainaxiang tablet and a preparation process thereof. Background technique [0002] Diangui Ainaxiang, also known as Baihua Jiuliming and Huaainaxiang, is derived from the dry whole herb of the Compositae plant False Dongfeng. It is mainly produced in southwestern Guangxi and southeastern Yunnan. It is often grown in forest edges, hillside shrubs or In the jungle. Diangui Ainaxiang is a traditional Chinese herbal medicine commonly used by ethnic minorities in Southwest China. Zhuang doctors believe that it has a slightly bitter taste and a slightly warm nature. Diangui Ainaxiang is a folk herbal medicine of the Zhuang nationality. Clinically, it has a unique curative effect on women's dysfunctional uterine bleeding, postpartum hemorrhage, early menstruation, postpartum metrorrhagia, postpartum edema, infertility, and vaginal sores. Howeve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/28A61K47/38A61K47/36A61K9/30A61P15/00A61P7/04A61P7/10A61P15/08A61P29/00
Inventor 张凯谢雁鸣伍彪
Owner GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD
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