A preparation method of cerium oxide nanoparticles and its anti-oxidation application

A technology of nanoparticles and cerium oxide, which is applied in the field of preparation of cerium oxide nanoparticles, can solve the problems such as biosafety can not be ignored, and achieve the effect of superior antioxidant activity and improvement of free radical scavenging activity.

Active Publication Date: 2011-12-21
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a common problem in nanomaterials itself - biological safety cannot be ignored

Method used

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  • A preparation method of cerium oxide nanoparticles and its anti-oxidation application
  • A preparation method of cerium oxide nanoparticles and its anti-oxidation application
  • A preparation method of cerium oxide nanoparticles and its anti-oxidation application

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Embodiment 1. Preparation of cerium oxide nanoparticles with uniform particle size by hydrothermal method.

[0028] Weigh 2.74g (NH 4 ) 2 Ce(NO 3 ) 6 and 10g CH 3 COONa was dissolved in 70ml of deionized water, then 10ml of glacial acetic acid was added to the solution, and stirred at room temperature for 1h. After that, the mixed solution was transferred to a polytetrafluoroethylene liner, sealed with a stainless steel hydrothermal kettle, and heated in an oven at 220° C. for 12 hours. Finally, the obtained yellow precipitate was centrifuged (6000 g, 10 min), washed with deionized water and ethanol several times, and then dried in an oven at 60° C. overnight.

Embodiment 2

[0029] Example 2. Preparation of cerium oxide nanoparticles with uniform particle size by hydrothermal method.

[0030] Weigh 5.48g (NH 4) 2 Ce(NO 3 ) 6 and 20g CH 3 COONa was dissolved in 140ml of deionized water, then 20ml of glacial acetic acid was added to the solution, and stirred at room temperature for 1h. After that, the mixed solution was transferred to a polytetrafluoroethylene liner, sealed with a stainless steel hydrothermal kettle, and heated in an oven at 220° C. for 12 hours. Finally, the obtained yellow precipitate was centrifuged (10000 g, 20 min), washed with deionized water and ethanol several times, and then dried overnight in an oven at 60°C.

Embodiment 3

[0031] Example 3. Preparation of cerium oxide nanoparticles with uniform particle size by hydrothermal method.

[0032] Weigh 1.63g Ce(NO 3 ) 3 and 10g CH 3 COONa was dissolved in 70ml of deionized water, then 10ml of glacial acetic acid was added to the solution, and stirred at room temperature for 1h. After that, the mixed solution was transferred to a polytetrafluoroethylene liner, sealed with a stainless steel hydrothermal kettle, and heated in an oven at 220° C. for 24 hours. Finally, the obtained precipitate was centrifuged (10000 g, 20 min), washed with deionized water and ethanol several times, and then dried overnight in an oven at 60°C.

[0033] In the above experiments, Ce(NO 3 ) 3 Other inorganic cerium salts can also be used instead.

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Abstract

The invention discloses a method for preparing cerium oxide nano particles and antioxidation use thereof and belongs to the field of biological nano materials. The method for preparing the cerium oxide nano particles comprises: adding glacial acetic acid into aqueous solution of a cerate and sodium acetate, uniformly stirring and mixing, heating the mixed solution for 5 to 60 hours, centrifuging,washing and drying an obtained yellow precipitate, and obtaining cerium oxide nano particles. Meanwhile, based on the subunit desorption and re-polymerization of proteins, the cerium oxide nano particles are filled into cavities of apoferritin which is a spherical cavity protein by controlling the opening and closing of the shell of the spherical protein, and thus, the biocompatible nano antioxidant is obtained. The method can improve the biocompatibility of the cerium oxide nano particles, lower the cytotoxicity of the cerium oxide nano particles and improve the antioxidant activity of the cerium oxide nano particles obviously.

Description

technical field [0001] The present invention relates to biological nanomaterials. Specifically, it is the preparation method of cerium oxide nanoparticles and its anti-oxidation application. Background technique [0002] Active oxygen refers to a class of oxygen-containing highly reactive molecules with active chemical properties and strong oxidizing ability in organisms, including superoxide anion radicals, hydroxyl radicals, hydrogen peroxide, etc. Many factors in the external environment, such as sun exposure, ultraviolet rays, electromagnetic radiation, environmental pollution, drug abuse, smoking and alcohol abuse, and excessive mental stress, will all cause the production of active oxygen. An appropriate amount of active oxygen is necessary to maintain life and health. However, once the active oxygen is excessive, it will cause lipid peroxidation, protein damage, DNA strand breaks, and cause aging or aging-related degenerative diseases such as cancer, cardiovascular ...

Claims

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Application Information

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IPC IPC(8): C01F17/00B82Y40/00
Inventor 马丁刘祥友袁荃严纯华
Owner PEKING UNIV
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