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New medicinal preparation for vagina

A preparation and vaginal technology, applied in the field of vaginal in-situ gel preparations, can solve the problems of easy loss, adverse reactions, unevenness, etc., and achieve the effects of increasing bioadsorption and weakening mobility

Inactive Publication Date: 2006-12-06
张东军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vaginal in-situ gel preparation provided by the present invention solves the problems of easy loss and accumulation of existing vaginal liquid pharmaceutical preparations, uneven coating and dead ends of effective medication in solid and semi-solid pharmaceutical preparations, and also avoids Eliminates adverse reactions caused by excessive local drug concentration in existing vaginal pharmaceutical preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: In situ gel formulations containing nifesamide.

[0044] Take nifesamide 0.00025%, 21% poloxamer 407, 10% poloxamer 188, sterile phosphate buffer solution (pH3.5-pH5) to the full amount. Nifesamide is dissolved in water, and the poloxamer is slowly added to the above solution under the conditions of ice bath and stirring, and stored under low temperature refrigeration until a clear solution is formed. The preparation has the functions of contraception and prevention of pathogenic microorganism infection.

Embodiment 2

[0045] Example 2: In situ gel formulations containing hyaluronic acid and nifesamide.

[0046] Take nifesamide 0.00025%, sodium hyaluronate 0.2%, 21% poloxamer 407, 10% poloxamer 188, sterile phosphate buffer solution (pH3.5-pH5) to the full amount. Sodium hyaluronate was dissolved in the buffer solution, and then the in-situ gel preparation was prepared according to the process of Example 1. The preparation has the functions of contraception and prevention of pathogenic microorganism infection.

Embodiment 3

[0047] Example 3: In situ vaginal gel preparation containing carbomer and acyclovir for women.

[0048] Take acyclovir 2%, benzalkonium chloride 0.02%, carbomer 934P 0.2%, mannitol 5%, 22% poloxamer 407, 10% poloxamer 188, sterile water to the full amount. Disperse carbomer in water, adjust the pH to 3.5~pH5 with sodium hydroxide solution, add drugs, benzalkonium chloride and mannitol, slowly add poloxamer to the above solution under ice bath and stirring conditions, and refrigerate at low temperature Store until a clear solution is formed.

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PUM

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Abstract

A medicine in the form of liquid for vagina contains medicine, in-situ gelatinizing substance, viscosity increasing high-molecular compound, lubricant, pH regulator and antiseptic. It features that it can be quickly spread on the surface of vagina to form a gel layer.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation for vaginal use. In particular, it relates to a vaginal in-situ gel (also known as in-body gel) preparation capable of changing from a liquid state to a gel state under suitable phase transition conditions. Background technique [0002] With the continuous development and progress of society, the scope of communication between people has become wider and the way of communication has become more diversified. The gynecological infectious diseases and sexually transmitted diseases caused by microbial infection or sexual contact have greatly increased, seriously threatening people's health. And most of the injured are women, such as bacterial, fungal, trichomonas vaginitis, cervicitis, metritis, pelvic inflammatory disease. Especially in recent years, sexually transmitted diseases have become a growing medical problem and the focus of attention of the whole world. Since the human being has not y...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/30A61K45/00A61P15/02A61P31/00A61P33/02
Inventor 张东军
Owner 张东军
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