Constant-temperature high-voltage electrostatic spray device and method preparing polymer medicine-carrying nanoparticles by using same

Abstract

The invention discloses a constant-temperature high-voltage electrostatic spray device and a method preparing polymer medicine-carrying nanoparticles by using the same. The device comprises an axial flow injection pump, an injector, a metal capillary type syringe needle, a high-voltage power supply, a powder receiving plate and a constant-temperature control device. The method for preparing the polymer medicine-carrying particles comprises the following steps of: dissolving active ingredients such as a polymer, a medicine and the like together in the same solvent to be mixed to form a consolute electrical spraying solution; then filling the obtained consolute electrical spraying solution in the injector and mounting the injector on the axial flow injection pump, switching on a power supply of an electric heating film, performing high-voltage electrostatic spraying in a high-voltage electric field after the temperature raises to a range of 40 to 80 DEG C thus the polymer medicine-carrying nanoparticles are obtained. As the automatic constant-temperature control device is added in the process in the invention, the polymer medicine-carrying nanoparticles can be prepared through single-step electrical spraying. The method has a simple preparation process, is easy to regulate and control, and is suitable for industrialized production; and the obtained polymer medicine-carrying nanoparticles have good dispersibility, and controlled release performance which can meet the design requirement.

Description

technical field [0001] The invention belongs to the field of preparation of polymer drug-loaded nanoparticles, in particular to a constant temperature and high-voltage electrostatic spray device and a method for preparing polymer drug-loaded nanoparticles by using the same. Background technique [0002] In recent years, due to the upsurge of nanotechnology, there are more and more reports on the application of high-voltage electrostatic spray technology to prepare functional micro- and nano-particles. Researchers have attempted to prepare various polymer materials (including natural and synthetic polymers, proteins, and even small molecules such as lecithin) into micro- and nano-particles through a high-voltage electrostatic spraying process, so as to play the role of materials at the nanoscale. functional effect. [0003] Due to its large surface area and good drug dispersion performance, polymer-based drug-loaded micro- and nanoparticles can reduce the irritation or side...

AI Technical Summary

Problems solved by technology

Correspondingly, a variety of drug-loaded micro- and nano-particle technologies emerge in endlessly, and these technologies generally have one or more of the following problems: (1) The preparation process is complicated; (2) Time-consuming; (3) Industrialization is difficult; (4) Involves a variety of equipment and facilities; (5) often must rely on temperature changes or high shear force to achieve preparation, and the processing process affects drug stability; (6) difficult to control particle size, etc.

With such a collection method, the process is relatively cumbersome, the operation is complicated, and the factors affecting the physical and chemical properties of the particles increase.

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