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Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof

A compound traditional Chinese medicine and arteriosclerosis technology, which is applied in the direction of drug combination, active ingredients of anhydride/acid/halide, medical preparations containing active ingredients, etc. It can solve problems such as unclear active ingredients, complex chemical ingredients, and difficult product quality. , to achieve the effects of mass production, stable preparation process, and increased content of active ingredients

Active Publication Date: 2012-06-13
QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a compound Chinese medicine for the prevention or treatment of arteriosclerosis based on the defects of complicated chemical components, unclear active ingredients, difficult to effectively control the product quality in practical application, and too many invalid components. Compound traditional Chinese medicine extract for preventing and treating arteriosclerosis

Method used

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  • Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof
  • Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof
  • Compound Chinese medicine extract preventing arteriosclerosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of the total extract of embodiment 1 Chinese medicine compound

[0030] The two medicines of Sanqi and Ligustrum lucidum in Ligustrum lucidum, Atractylodes macrocephala, Eucommia, Notoginseng, Daji, Salvia, Coptidis, and Bergamot (weight ratio 1:1:1:2:1:2:1:1) Grinding into coarse powder, reflux extracting with 60 volume % ethanol which is 12 times, 10 times and 8 times of the amount of the medicinal material, respectively, for 2 hours each time, combining the extracts, recovering the ethanol and making the concentration of the ethanol extraction part 1ml equivalent to 1g of crude drug; The rest of the medicinal materials in the prescription were decocted and extracted three times with 12 times, 10 times and 8 times the amount of water respectively, each time for 2 hours, combined three water extracts, concentrated under vacuum and reduced pressure to 1g medicinal materials / ml extract, water extracted part and The above alcohol extraction parts were comb...

Embodiment 2

[0031] The preparation of the effective extraction part of embodiment 2 compound total extract

[0032] Extract once with petroleum ether of 5 times the volume of the total compound extract, and separate the petroleum ether layer; then extract once with 3 times and 2 times the volume respectively, separate and obtain the petroleum ether layer, combine the petroleum ether extracts three times, and recover the petroleum ether, Then vacuum-dried at 0.08MPa and 55°C to obtain the effective extraction part A;

[0033]Add 12, 8, and 5 times the amount of ethyl acetate to the residue after the petroleum ether extraction of the total extract, respectively, and extract the obtained ethyl acetate extraction parts, recover the solvent, and vacuum-dry at 0.07MPa and 60°C to obtain the compound effective Extraction site B;

[0034] The residue after extraction with ethyl acetate was extracted with 10, 8, and 6 times the amount of n-butanol respectively, the obtained extracts were combined...

Embodiment 3

[0040] The preparation method of embodiment 3 compound Chinese medicine extract capsules

[0041] The extracts are combined according to the following parts by weight:

[0042] Effective extraction part A 1 part

[0043] 2 copies of effective extraction part B

[0044] 5 copies of effective extraction part C

[0045] Mix the extracts in the above proportions, the effective extraction part A with the same amount of starch, and then mix it with the effective extraction part B, and finally mix it with the effective extraction part C. After the three are mixed evenly, dry granulation is performed, and after drying under reduced pressure, Whole grains, filled with No. 2 capsules, polished, and packaged for quality inspection.

[0046] Measure the capsule that makes with HPLC method, it contains each active ingredient content result and sees Table 1:

[0047] Table 1 FTZCE capsule HPLC assay results

[0048]

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Abstract

The invention discloses a compound Chinese medicine extract preventing arteriosclerosis, comprising the following effective ingredients: dried alcohol, Beta-sitosterol, hexacosanoic acid, butenolide III, oleanolic acid, berberine, jateorhizine, coptisine, salvianic acid A, salvianolic acid B, ring-tetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1, encommiol and the like. A preparation method of the extract is as follows: taking salvia miltiorrhiza, fructus ligustri lucidi, rhizoma coptidis, cirsium japonicum, eucommia bark, atractylodes macrocephala koidz, radix pseudo-ginseng and bergamot as raw materials, conducting C1-3 alcohol extraction and / or water extraction on a total extract, then extracting the total extract by organic solvents with different polarities so as to obtain all the effective ingredients, and finally mixing the effective ingredients so as to obtain the compound Chinese medicine extract preventing arteriosclerosis. As for the compound Chinese medicine extract, a large number of ineffective chemical ingredients are removed, so that the content of effective ingredients is improved greatly, the influence on product processing and preparation quality caused by the ineffective ingredients is reduced, the preparation process is stable, the product quality is controllable, and the mass production is facilitated.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine extract for preventing and treating arteriosclerosis and a preparation method thereof. Background technique [0002] Arteriosclerosis is a common and frequently-occurring disease in middle-aged and elderly people. Atherosclerosis (Atherosclerosis, AS) is the most common and important type of arteriosclerosis, which is characterized by the deposition of lipids and the accumulation of complex carbohydrates in the intima of the affected arteries, followed by fibrous tissue hyperplasia and calcium deposition, and There is a lesion in the arterial media. The disease mainly involves large and medium-sized muscular elastic arteries, especially the aorta, coronary arteries, and cerebral arteries. It often leads to serious consequences such as occlusion of the lumen or rupture and bleeding of the vessel wall, and is the main cause of my...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/704A61K31/575A61K31/56A61K31/4375A61K31/352A61K31/343A61K31/201A61K31/20A61K31/192A61K31/015A61K36/752A61P9/10
CPCA61K31/201A61K31/20A61K31/704A61K36/46A61K31/015A61K36/638A61K36/284A61K31/352A61K36/258A61K31/192A61K36/718A61K36/752A61K31/575A61K31/4375A61K36/28A61K31/7048A61K31/343A61K31/56A61P9/10A61K2300/00
Inventor 郭姣唐春萍
Owner QINGDAO BAILI CAIXIN MEDICAL TECH CO LTD
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