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Reduced glutathione percutaneous absorption preparation and preparation method thereof

A technology of glutathione and reduced form, applied in tripeptide components, pharmaceutical formulations, aerosol delivery, etc., can solve the problems of not being able to inject every day, low bioavailability, inconvenient use, etc., and achieve rapid onset of effect , high bioavailability, maintain the effect of reduction

Active Publication Date: 2011-06-22
CHENGDU JOY YOUNG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Intravenous injection is a 100% method to effectively inject GSH into the blood, but GSH intravenous injection has the following disadvantages: 1. Inconvenient use and painful injection; 2. Cannot be injected every day; 3. The half-life of GSH in the blood after injection is relatively short , about 7~10min
Oral dosage forms such as capsules and tablets are convenient to use, but the bioavailability of GSH is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The present invention also provides a preparation method of reduced glutathione percutaneous absorption preparation, which includes the following steps: adding water to dissolve 50-550 parts of reduced glutathione according to the weight ratio, and adjusting the pH value of the solution to 5.5-6 (Using commonly used reagents to adjust the pH value, NaOH solution is preferred), add 75 to 150 parts of auxiliary materials including reduced glutathione and dissolve the auxiliary materials, mix well, and remove the oxygen in the solution to obtain reduced glutathione Glutathione percutaneous absorption preparation; wherein, the auxiliary material is at least one of γ-cyclodextrin, derivatives of γ-cyclodextrin, α-cyclodextrin, and derivatives of α-cyclodextrin.

[0022] Wherein, in the preparation method of the reduced glutathione percutaneous absorption preparation of the present invention, the oxygen in the solution can be removed by conventional methods, preferably by inje...

Embodiment 1

[0026] Example 1 Preparation of reduced glutathione percutaneous absorption preparation of the present invention

[0027] Raw materials and reagents: GSH (injection grade), vitamin C (pharmaceutical grade), γ-cyclodextrin (pharmaceutical grade), 50 wt% benzalkonium chloride solution, saturated NaOH solution, medicinal purified water, pure nitrogen.

[0028] Preparation process: Boil 500ml of pure water for 5-10 minutes, add 30g of vitamin C to dissolve, then add 100g of GSH, stir and dissolve, adjust the pH value of the solution to 5.6 with NaOH solution, add 75g of γ-cyclodextrin and stir until dissolved, add water to volume To 1L, lead the nitrogen tube to the bottom of the solution, flush the solution with nitrogen for 5 minutes, pack it, and store it at low temperature and away from light.

Embodiment 2

[0029] Example 2 Preparation of Reduced Glutathione Transdermal Absorption Preparation of the Present Invention

[0030] Raw materials and reagents: GSH (injection grade), vitamin C (pharmaceutical grade), γ-cyclodextrin (pharmaceutical grade), 50 wt% benzalkonium chloride solution, saturated NaOH solution, medicinal purified water, pure nitrogen.

[0031]Preparation process: Boil 500ml of pure water for 5-10 minutes, add 40g of vitamin C to dissolve, then add 200g of GSH, stir and dissolve, adjust the pH value of the solution to 5.9 with NaOH solution, add 100g of γ-cyclodextrin and stir until dissolved, add water to volume To 1L, lead the nitrogen tube to the bottom of the solution, flush the solution with nitrogen for 10 minutes, pack it, and store it at low temperature and away from light.

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PUM

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Abstract

The invention relates to a reduced glutathione percutaneous absorption preparation and a preparation method thereof, and belongs to the field of medicinal preparations. In the technical problem, the invention provides a reduced glutathione percutaneous absorption preparation which has the sustained-release effect. The reduced glutathione percutaneous absorption preparation is prepared from an auxiliary material bag and reduced glutathione, wherein an auxiliary material is at least one of gamma-cyclodextrin, a derivative of the gamma-cyclodextrin, alpha-cyclodextrin and a derivative of the alpha-cyclodextrin. The reduced glutathione percutaneous absorption preparation has the advantages of quick response, long half-life period and high bioavailability, is convenient to use and does not have pain. The reduced glutathione provides a new preparation, and has a wide application prospect.

Description

technical field [0001] The invention relates to a reduced glutathione percutaneous absorption preparation and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Reduced glutathione (GSH) is a peptide naturally synthesized in human cytoplasm, composed of glutamic acid, cysteine ​​and glycine, containing thiol (-SH), widely distributed in various cells of the body, especially in Liver, kidney, and red blood cells are more widely distributed. There are mainly two types of glutathione in the human body: reduced (GSH) and oxidized (GSSG), and the ratio of the two is about 100:1. GSH is the prosthetic group of glyceraldehyde phosphate dehydrogenase, and the coenzyme of glyoxalase and triose dehydrogenase, and participates in the tricarboxylic acid cycle and glucose metabolism in the body. GSH has a wide range of clinical applications, such as: GSH can be directly used for liver damage, viral hepatitis, fatty liver, ...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61K9/06A61K9/12A61K9/70A61K47/48A61P1/16A61P1/18A61P3/10A61P9/00A61P13/12A61P27/02A61K47/61A61K47/69
Inventor 陶继善陈青内阳・帕泰尔
Owner CHENGDU JOY YOUNG BIOTECH CO LTD
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