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Hot-melt pressure-sensitive adhesive and preparation method and application thereof

A hot-melt pressure-sensitive adhesive and a part of the technology are applied in the field of preparation of hot-melt pressure-sensitive adhesives, which can solve the problems of drug loss, easy oxidation, and skin pain, and achieve reduced aging and oxidation, good initial skin viscosity, and moderate peeling. the effect of strength

Active Publication Date: 2013-06-05
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. The hot melt adhesive matrix is ​​prone to oxidation during the preparation process, which will affect the adhesive stability and skin adhesion performance of the patch
[0006] 2. Medical hot-melt adhesives are modified from traditional hot-melt adhesives, and their bonding strength is high, which will cause skin pain and damage when peeling off
On the other hand, in order to avoid skin irritation, the medical hot-melt adhesive matrix usually does not contain polar components and is a hydrophobic polymer with poor moisture absorption and perspiration performance. When the skin perspires a lot, it will affect the performance of the patch.
[0007] 3. The compatibility between the hot melt adhesive matrix and hydrophilic drugs is poor, and the addition of hydrophilic drugs will cause the performance of the hot melt adhesive matrix to decline
And volatile oil is a kind of main component in traditional Chinese medicine patch, under the higher melting temperature and coating temperature, can cause a large amount of loss of volatile oil and poor thermal stability medicine
Coating at low temperature will affect the uniformity of coating due to the poor fluidity of the substrate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 hot-melt pressure-sensitive adhesive

[0038] Raw materials were weighed: 35g of thermoplastic elastomer SIS (purchased from Eni Company, brand 9113), 40g of terpene resin, 40g of liquid paraffin, and 1g of microcrystalline wax.

[0039] Preparation method of hot-melt pressure-sensitive adhesive: Add 35g thermoplastic elastomer SIS, 15g liquid paraffin, and 0.5g microcrystalline wax into a three-necked round-bottomed flask, ventilate nitrogen for 5 minutes to remove air, heat up to the mixture melts, and at the same time pass nitrogen protection, at 140°C Temperature control, stirring, the stirring speed is 100 rpm, until the mixture forms a uniform and transparent viscous colloid; then, 40g of terpene resin, 25g of liquid paraffin, and 0.5g of microcrystalline wax are put into the above mixture, and controlled at 100°C. temperature, stirred for half an hour, the stirring speed was 100 rpm, and nitrogen protection was applied at the same ...

Embodiment 2

[0040] The preparation of embodiment 2 hot-melt pressure-sensitive adhesive

[0041] Raw materials were weighed: 35 g of thermoplastic elastomer SIS (purchased from Kraton, brand 1163), 30 g of terpene resin, 10 g of rosin resin, 35 g of naphthenic oil, 1 g of microcrystalline wax, and 1 g of Tween 80.

[0042]Preparation method of hot-melt pressure-sensitive adhesive: Add 35g of thermoplastic elastomer SIS and 10g of naphthenic oil into a three-neck round-bottomed flask, ventilate nitrogen for 5 minutes to remove air, heat up to the mixture melted, and at the same time pass nitrogen protection, control temperature at 140°C, stir, Stirring speed is 100 revolutions / second, until mixture forms uniform transparent viscous colloid; Then, terpene resin 30g, rosin resin 10g and naphthenic oil 25g, Tween 801g, microcrystalline wax 1g drop into above-mentioned mixture, in 100 Control the temperature at ℃, stir for half an hour, the stirring speed is 100 rpm, and at the same time pass ...

Embodiment 3

[0043] The preparation of embodiment 3 hot-melt pressure-sensitive adhesive

[0044] Raw materials were weighed: 70 g of thermoplastic elastomer SIS (purchased from Kraton, brand 1163), 70 g of hydrogenated petroleum resin, 80 g of liquid paraffin, and 5 g of rubber accelerator.

[0045] Preparation method of hot-melt pressure-sensitive adhesive: Add 70g of thermoplastic elastomer SIS, 70g of hydrogenated petroleum resin, 80g of liquid paraffin, and 5g of rubber accelerator into a three-necked round-bottomed flask, ventilate nitrogen for 5 minutes to remove air, heat up until the mixture melts, and simultaneously ventilate nitrogen to protect , control the temperature at 120°C, stir at a stirring speed of 120 rpm, until the mixture forms a uniform and transparent viscous colloid, and finally, cool the above colloid to 95°C and pour it out to obtain a hot-melt pressure-sensitive adhesive.

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PUM

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Abstract

The invention discloses a hot-melt pressure-sensitive adhesive, which is prepared from the following raw materials in part by weight: 35 to 70 parts of thermoplastic elastomer SIS, 20 to 70 parts of tackifying resin, 40 to 80 parts of plasticizer and 1 to 5 parts of antioxidant and / or antiageing agent, wherein the tackifying resin is one or any combination of abietic resin, terpene resin, C5 petroleum resin and hydrogenated petroleum resin; the plasticizer is one or any combination of liquid paraffin, Tween-80, dibutyl phthalate, wool grease, castor oil and naphthenic oil; and the antioxidantand / or antiageing agent is one or any combination of microcrystalline wax, gallic acid-propyl ester and a rubber accelerator. The hot-melt pressure-sensitive adhesive has moderate adhesion and good antioxidation, is fitted well, and also has lower softening point and good compatibility with medicines. In addition, the invention also discloses a preparation method for the hot-melt pressure-sensitive adhesive and application of the hot-melt pressure-sensitive adhesive in preparing traditional Chinese medicinal adhesive plaster products.

Description

technical field [0001] The invention relates to a hot-melt pressure-sensitive adhesive, in particular to a preparation method of the hot-melt pressure-sensitive adhesive and its application in medicine. Background technique [0002] In traditional Chinese medicine transdermal administration, natural rubber is mainly used as the adhesive layer matrix. This kind of rubber ointment is a plaster made by mixing the medicinal material extract with the matrix, and then coating it on the backing material. Rubber paste requires a large amount of gasoline in production, which is prone to explosion and has low safety and productivity; at the same time, this type of patch has a small drug load (generally 100cm 2 Ointment content is only about 2g), so it has a great impact on the continuous performance of the drug effect; in addition, the rubber ointment has poor air permeability and has skin irritation and allergic reactions. The above-mentioned defects have seriously restricted the d...

Claims

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Application Information

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IPC IPC(8): C09J153/02C09J193/04C09J147/00C09J157/02A61K47/32A61K47/34A61K47/44A61K9/70A61K36/00A61K47/06A61K47/26
Inventor 汤秀珍王承潇沈平孃刘志远杜晨捷
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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