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Carrier adhesive for plaster and patch and preparation method thereof

A technology of adhesives and application methods, applied in the direction of adhesives, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of large physical stimulation, easy allergic reactions, strong pain, etc., achieve low dosing temperature, good Adhesive force, pain relief effect

Active Publication Date: 2014-10-15
CHINA PETROCHEMICAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the carrier adhesive used in domestic plasters or patches is natural rubber, and the plasters or patches prepared with natural rubber as the carrier adhesive have many shortcomings: 1) Containing natural proteases makes some people prone to allergic reactions; 2) Hair or patches when peeled off Skin stretching produces greater physical stimulation and stronger pain

Method used

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  • Carrier adhesive for plaster and patch and preparation method thereof
  • Carrier adhesive for plaster and patch and preparation method thereof
  • Carrier adhesive for plaster and patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The required SIS is synthesized by professionals. And the technical parameters of SIS are: linear structure, block ratio 15 / 85, molecular weight 110,000, diblock content 20%, diblock molecular weight 70,000. According to the application formula, 100 parts of SIS, 75 parts of naphthenic oil, 145 parts of hydrogenated C5 petroleum resin, and 1010 0.2% of antioxidant are stirred and melted at 180°C to make a hot-melt pressure-sensitive adhesive. The relevant properties are as follows:

[0028]

Embodiment 2

[0030] Add medicine and apply on the basis of embodiment 1, make plaster. The medicine added is the prescription medicine of Shangshi Qutong ointment provided by Beijing Lingrui, and the proportion of medicine added is 15%. The relevant performance is as follows:

[0031]

Embodiment 3

[0033] The technical parameters of SIS are the same as in Example 1, according to the application formula, 100 parts of SIS, 80 parts of naphthenic oil, 140 parts of hydrogenated C5 petroleum resin, and 0.2% of antioxidant 1010 are stirred and melted at 180°C to form a hot-melt press Sensitive glue, and dosing coating, makes plaster, and the medicine that adds is the prescription medicine of Shangshi Qutong plaster that Beijing Lingrui provides, and the ratio of adding medicine is 18%. The relevant performance is as follows:

[0034]

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Abstract

The invention discloses a carrier adhesive for plasters and patches and a preparation method thereof. The adhesive is prepared from the following components: 100 parts by weight of a styrene-isoprene-styrene (SIS) block copolymer; 65-85 parts by weight of a plasticizer; 130-155 parts by weight of tackifying resin; and 0.1-0.5wt% of an antioxidant additionally. The styrene-isoprene-styrene (SIS) block copolymer has a linear structure, a block ratio of 14-16 / 86-84, and a molecular weight of 0.1-0.13 million. The diblock content is 18-25wt%, and the diblock molecular weight is 60-80 thousands. The carrier adhesive provided in the invention not only has good adhesion when a total drug carrying amount is not higher than 20% of the carrier adhesive, but also has a low peeling force, thus being in favor of generating small physical stimulations resulted from hair or skin pulling during peeling, and reducing the pain when peeling plasters or patches. At the same time, the drug adding temperature is low, and the applying temperature after drug adding is lower.

Description

technical field [0001] The present invention relates to plaster, patch carrier adhesive for skin application. Specifically, it relates to a hot-melt pressure-sensitive adhesive of styrene and isoprene block copolymer and a preparation method thereof. Background technique [0002] Technical personnel in the industry know that styrene and isoprene block copolymer SIS has good cohesion and excellent adhesion performance, and at the same time has low modulus, low melt viscosity and good coating performance. It is a very good hot melt Pressure sensitive adhesive base material. SIS hot-melt pressure-sensitive adhesive is mainly made by mixing SIS, plasticizer and tackifying resin in a certain proportion and then heating and melting. Through the selection of SIS grades and the adjustment of application formulas, hot-melt pressure-sensitive adhesives with different properties including initial adhesion, holding strength and peeling strength can be obtained. [0003] The plaster o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09J153/02C09J193/04C09J145/00C09J157/02A61K47/32A61K9/70
Inventor 袁煜艳史官正张志斌李望明王勇何林
Owner CHINA PETROCHEMICAL CORP
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