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Detection method for lung-soothing syrup

A detection method and syrup technology are applied in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as difficulty in controlling product quality.

Active Publication Date: 2011-02-02
九寨沟天然药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention aims at the disadvantages that the existing quality control standards are simple and the product quality is not easy to control. According to the content, characteristics and preparation process of each medicinal material in this prescription, a specific and feasible method for identification and content determination is researched and developed, so as to effectively control the quality of the lung syrup, thereby ensuring the clinical efficacy of the preparation

Method used

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  • Detection method for lung-soothing syrup
  • Detection method for lung-soothing syrup
  • Detection method for lung-soothing syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Properties: This product is a brown viscous liquid; sweet and slightly salty.

[0107] Identification: Take 1ml of this product, add 10ml of water, add nitric acid to make it acidic, add 1ml of silver nitrate test solution, and then form a white curd-like precipitate, which is soluble in ammonia test solution; or

[0108] Take 5ml of this product, add sodium hydroxide test solution to make it alkaline, and heat it to produce ammonia odor, which can turn the wet red litmus paper blue;

[0109] Take 20ml of this product, add water to dilute it to 50ml, centrifuge, take the supernatant, and pass it through the treated D with 15mm inner diameter and 12cm height. 101 type macroporous adsorption resin column, eluted with water until the eluent was colorless, discarded the water, then eluted with 100ml of 70% ethanol, collected the eluate, evaporated to dryness, added 20ml of water to the residue to dissolve, and saturated n-butyl Alcohol extraction 2 times, 20ml each time, c...

Embodiment 2

[0117] Properties: This product is a brown viscous liquid; sweet and slightly salty.

[0118] Identification: Take 1ml of this product, add 10ml of water, add nitric acid to make it acidic, add 1ml of silver nitrate test solution, and then form a white curd-like precipitate, which is soluble in ammonia test solution; or

[0119] Take 5ml of this product, add sodium hydroxide test solution to make it alkaline, and heat it to produce ammonia odor, which can turn the wet red litmus paper blue;

[0120] Take 20ml of this product, add water to dilute it to 50ml, centrifuge, take the supernatant, and pass it through the treated D with 15mm inner diameter and 12cm height. 101 type macroporous adsorption resin column, eluted with water until the eluent was colorless, discarded the water, then eluted with 100ml of 70% ethanol, collected the eluate, evaporated to dryness, added 20ml of water to the residue to dissolve, and saturated n-butyl Alcohol extraction 2 times, 20ml each time, c...

Embodiment 3

[0123] Properties: This product is a brown viscous liquid; sweet and slightly salty.

[0124] Inspection: It should meet the relevant regulations under the item of Appendix IH syrup of the Chinese Pharmacopoeia 2005 edition;

[0125] Content determination: use octadecylsilane bonded silica gel as filler; acetonitrile: 0.1% phosphoric acid solution = 9:87 as mobile phase; detection wavelength is 207nm, and the number of theoretical plates should not be less than 3000 based on the ephedrine hydrochloride peak Get 10 mg of ephedrine hydrochloride reference substance, accurately weighed, put in a 100ml measuring bottle, add methanol to dilute to the mark, shake up, accurately measure 2ml, put in a 25ml measuring bottle, add mobile phase to dilute to the mark, shake up, that is Obtain a reference substance solution containing 8 μg of ephedrine hydrochloride per 1 ml; accurately measure 10 ml of this product, put it in a 100 ml measuring bottle, add 60 ml of methanol, use an ultraso...

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Abstract

The invention provides a quality detection method for lung-soothing syrup. The method comprises part or all of properties, inspection, identification and content measurement items, wherein the properties need to satisfy relevant regulations under Section Syrup; in the inspection, the syrup needs to conform to the relevant regulations in Section Syrup, Appendix IH, Part 1, Chinese Pharmacopedia (2005 Edition); in the component identification, ammonium chloride and licorice are identified; and in the content measurement, the content of ephedrine hydrochloride and the content of ammonium chloride are measured. The quality detection method has the advantages of high precision, high stability, favorable reproducibility, high recovery rate and accurate measurement result, enhances the quality control standard of lung-soothing syrup, and can effectively control illegal manufacturers from producing fake and poor-quality lung-soothing syrup, thereby ensuring the clinical curative effect of the preparation.

Description

technical field [0001] The invention relates to a detection method for Shufei syrup, which belongs to the technical field of quality control of medicines. Background technique [0002] Shufei syrup is a variety recorded in the twelfth volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". The standard number is WS3-B-2439-97. The prescription is ammonium chloride, ephedrine hydrochloride, licorice Bubu liquid extract and Platycodon grandiflorum liquid extract are compound syrups of Chinese and Western medicines. It has the effect of antitussive and expectorant, clinically used in the treatment of respiratory diseases such as acute and chronic bronchitis, cough, asthma, phlegm, etc. Common medicines for respiratory diseases. However, the existing technology does not carry out quality control on several important components wherein, ephedrine hydrochloride, which has the effect of relieving cough and relieving asthma, is a chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/14G01N31/02G01N30/90A61K9/00A61K31/137A61K36/906A61P11/00A61P11/06A61K33/20G01N21/78A61P11/10G01N30/02
Inventor 黎勇钟茂团温国梁古莉邹波林剑
Owner 九寨沟天然药业股份有限公司
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