Granules comprising cefprozil lipidosome and preparation method thereof

Abstract

The invention relates to cefprozil lipidosome, a preparation method thereof and granules comprising the same. The cefprozil lipidosome comprises the following components in proportion by weight: 1 cefprozi, 1.25-5 hydrogenated soybean lecithin, 1.25-5 egg yolk lecithin, 2.5-10 cholesterin and 0.1-3 vitamin E. The cefprozil granules not only conform to the requirements of Chinese pharmacopoeia, but also has the advantages of more stable storage at normal temperature, faster drug effect-taking, and obviously improved bioavailability compared with the common cefprozil pharmaceutical composition.

Description

technical field [0001] The invention relates to a cefprozil liposome, a preparation method thereof and granules containing it. The cefprozil granules are more stable than common cefprozil pharmaceutical compositions, exhibit faster drug effects and have significant bioavailability The improved advantages belong to the technical field of medicine. Background technique [0002] Acute cholecystitis is a common disease. In my country, according to literature reports, it ranks second among acute abdominal surgical diseases, second only to acute appendicitis, and is more common than acute intestinal obstruction and ulcer perforation. The disease is more common in middle-aged people aged 35 to 40, and women are more likely to suffer from it than men, especially women who are obese and have multiple pregnancies. The onset of acute cholecystitis is due to obstruction of the cystic duct by stones, resulting in the retention of bile in the gallbladder, followed by bacterial infection...

AI Technical Summary

Problems solved by technology

[0013] Chinese patent CN101700232A discloses a cefprozil submicron emulsion solid preparation and its new application, which is characterized in that it is composed of cefprozil, egg yolk lecithin, poloxamer 188 and sodium deoxycholate, and the prepared cefprozil sub Microemulsion encapsulation efficiency is low

[0014] Chinese patent CN101032489A discloses a kind of cefprozil dispersible tablet and preparation method thereof, described dispersible tablet is to adopt simple cefprozil crude drug without any modification to make, and the solubility, stability and bioavailability of the obtained preparation are average. poor

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