Dry suspension containing cefprozil liposome and preparation method thereof
A technology of cefprozil and dry suspension, applied in the field of medicine, can solve the problems of low encapsulation rate of cefprozil submicroemulsion, poor preparation solubility, stability and bioavailability, etc., so as to improve bioavailability, avoid Peak and valley phenomenon, better storage effect
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Embodiment 1
[0070] Embodiment 1: the preparation of cefprozil liposome
[0071] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
Hydrogenated Soy Lecithin
156.25
312.50
625.00
Hydrogenated egg yolk lecithin
156.25
312.50
625.00
312.50
625.00
1250.00
Vitamin E
50.00
100.00
200.00
total
737.50
1475.00
2950.00
[0072] Preparation:
[0073] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.
[0074] (B) Weigh th...
Embodiment 2
[0079] Embodiment 2: the preparation of cefprozil liposome
[0080] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
[0081] Hydrogenated Soy Lecithin
256.25
512.50
1025.00
Hydrogenated egg yolk lecithin
256.25
512.50
1025.00
cholesterol
512.50
1025.00
2050.00
Vitamin E
50.00
100.00
200.00
total
1137.50
2275.00
4550.00
[0082] Preparation:
[0083] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil....
Embodiment 3
[0089] Embodiment 3: the preparation of cefprozil liposome
[0090] Name of raw material
Dose 1 (mg)
Dose 2 (mg)
Dose 3 (mg)
cefprozil
62.50
125.00
250.00
Hydrogenated Soy Lecithin
312.50
625.00
1250.00
Hydrogenated egg yolk lecithin
312.50
625.00
1250.00
cholesterol
625.00
1250.00
2500.00
Vitamin E
50.00
100.00
200.00
total
1362.50
2725.00
5450.00
[0091] Preparation:
[0092] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and vitamin E in an appropriate amount of absolute ethanol according to the prescription amount, mix evenly, filter, evaporate and remove absolute ethanol on a rotary evaporator to obtain a phospholipid film, vacuum Dry under reduced pressure. The amount of dehydrated alcohol used is 30 times of the amount of cefprozil.
[0093] (B) Weig...
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