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Medicament microcapsule composite calcium deficiency calcium phosphate bone cement and use, preparation method and application thereof

A technology of calcium phosphate bone cement and calcium-deficient calcium phosphate, which is applied in drug combination, microcapsules, medical science, etc., can solve the problems of small drug loading, short drug effect cycle, and toxic effects on organs, and achieve good biological Compatibility, short hospital stay, no toxic side effects

Inactive Publication Date: 2010-12-08
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the explosive release effect of the drug in the body in the existing local drug delivery system for the treatment of osteomyelitis, the drug effect cycle is short and it is easy to cause a series of systemic side effects, or poor tissue compatibility and rejection Reaction, strong heat release during the curing process can easily cause burns and necrosis of surrounding tissues, limitations in the selection of antibiotics, toxic effects on organs, and incomplete drug release; or the material is brittle, poor in elastic strength, and difficult to absorb in the body. Due to the defects of causing osteolysis and small drug load, a drug microcapsule composite calcium-deficient calcium phosphate bone cement and its use, preparation method and application are provided.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]Calcium-deficient calcium phosphate bone cement compounded with drug microcapsules: 10 grams of calcium-deficient calcium phosphate bone cement powder containing calcium hydrogen phosphate and tetracalcium phosphate with a particle size of less than 10 μm, including 5.737 grams of tetracalcium phosphate and 4.263 grams of calcium hydrogen phosphate. 2 grams of mycin drug liposomes can be evenly mixed.

[0034] Wherein, the vancomycin liposome is prepared by the following method: Weigh 40mg vancomycin, 280mg soybean lecithin and 250mg serum cholesterol and dissolve them in 20mL propyl acetate, transfer to a round bottom flask, and heat Under the temperature of the water bath, the rotating speed is 200r / min, and the organic solvent is evaporated under reduced pressure to form a film, and then vacuum-dried at room temperature for 36 hours; to 7, fully swelled for half an hour, then ultrasonicated in a water bath for 15 minutes, and then ultrasonicated with an ultrasonic cel...

Embodiment 2

[0038] Drug microcapsules composite calcium-deficiency calcium phosphate bone cement: 10 grams of calcium-deficiency calcium phosphate bone cement powder containing calcium hydrogen phosphate and tetracalcium phosphate with a particle size of less than 10 μm, including 5.737 grams of tetracalcium phosphate and 4.263 grams of calcium hydrogen phosphate, and Cephalicillin liposome 3g can be evenly mixed.

[0039] Wherein, the liposome of cephalosporin is prepared by the following method: Weigh 40mg cephalosporin, 400mg hydrogenated soybean lecithin and 130mg protein cholesterol and dissolve them in 30mL chloroform, transfer them to a round bottom flask, and place them in a water bath at 45°C. Under high temperature, the rotation speed is 150r / min, the organic solvent is evaporated under reduced pressure to form a film, and vacuum dried at room temperature for 48 hours; then add 20mL of Tween 80 aqueous solution and 30mL of normal saline, adjust the pH to 7, and fully swell for 1 ...

Embodiment 3

[0043] Drug microcapsule composite calcium-deficiency calcium phosphate bone cement: 10 grams of mixed calcium phosphate powder containing calcium hydrogen phosphate and tetracalcium phosphate with a particle size of less than 10 μm, including 5.737 grams of tetracalcium phosphate and 4.263 grams of calcium hydrogen phosphate, mixed with vancomycin 2 grams of prime drug liposomes can be evenly mixed.

[0044] Wherein, the preparation of the vancomycin liposome is the same as in Example 1.

[0045] The above-mentioned drug microcapsules combined with calcium-deficiency calcium phosphate bone cement was added to 5 grams of normal saline to make a paste, and then solidified as a sample. After testing, the setting time was 17 minutes, and the compressive strength reached 30 MPa, which met the requirements for bone defect filling. Require.

[0046] At the same time, due to the antibacterial and anti-inflammatory effects of the drug and the rapid degradation rate of the material af...

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Abstract

The invention discloses medicament microcapsule composite calcium deficiency calcium phosphate bone cement and the use, the preparation method and the application thereof. The bone cement contains a medicament microcapsule in effective treatment dosage and calcium deficiency calcium phosphate bone cement, wherein the calcium deficiency calcium phosphate bone cement comprises calcium hydrophosphate and tetracalcium phosphate, and a molar ratio of calcium to phosphorus is 1.5. The bone cement is prepared by uniformly mixing the medicament microcapsule and the calcium deficiency calcium phosphate bone cement. When in use, the medicament microcapsule composite calcium deficiency calcium phosphate bone cement is uniformly mixed with curing liquid physiological saline or other saline solutions to be implanted into a body, wherein the liquid-to-solid ratio of the medicament microcapsule composite calcium deficiency calcium phosphate bone cement to the curing liquid is 0.25-2.6g / mL. After the bone cement is implanted into the human body for curing, a medicament is slowly released by a microstructure of curing body and has effects of inflammation elimination and sterilization during bone repair; and a micropore formed after the medicament is slowly released is beneficial to growing new bone tissue, accelerating the degradation of materials and effectively promoting the rapid healing of bones.

Description

technical field [0001] The invention relates to a drug microcapsule composite calcium-deficiency calcium phosphate bone cement and its use, preparation method and application. Background technique [0002] Osteomyelitis refers to an inflammatory disease caused by purulent bacteria infecting the bone marrow, bone cortex and periosteum. It may be caused by blood, or caused by trauma or surgical infection, and it may also be caused by furuncle or other lesions into the blood. And up to bone tissue pathogenic. Osteomyelitis can be divided into acute and chronic types according to the development of the disease. Acute osteomyelitis has high fever and local pain at the onset. If the diagnosis is not timely, it will turn into chronic osteomyelitis with ulceration, thick flow, sequestrum or cavity formation. Among them, the two ends of limb bones are most vulnerable, especially the hip joint. Clinically, there are often recurrent cases that have not healed for many years. The tre...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/54A61K38/14A61K31/43A61K9/50A61K9/127A61P19/08A61P31/04
Inventor 苏佳灿曹烈虎禹宝庆李明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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