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Novel application of wine-roasted Chinese goldthread processed product

The invention relates to a technology for roasting Coptis chinensis with wine and its application, which is applied in the pharmaceutical field of preparing insulin sensitizers and PPARγ agonists to achieve the effects of improving insulin resistance, improving the treatment of diabetes and its complications, and having excellent drug efficacy.

Inactive Publication Date: 2010-11-03
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional Chinese medicine Coptis chinensis is also commonly used in the prescription of Chinese patent medicines for the treatment of diabetes. In 2006, the analysis results of diabetes medication in domestic hospitals showed that among the top ten products, Tangmaikang granules (including Coptis chinensis, with a market share of 22.1 %, about 100 million yuan), Jinqi Jiangtang Tablets (including Coptis chinensis, with a market share of 11.6%, about 50 million yuan), ranking 2nd and 4th respectively, are widely used in TCM clinical practice, but in TCM clinical practice Even put forward the statement that "Huanglian is not the main medicine for treating diabetes (diabetes)"

Method used

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  • Novel application of wine-roasted Chinese goldthread processed product
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Examples

Experimental program
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Effect test

Embodiment 1

[0026] Example 1 Preparation of processed wine-cured Coptis chinensis of the present invention

[0027] Take the clean Coptis chinensis, and fry it dry according to the method of roasting with wine (Appendix II D). For every 100kg of Coptis chinensis, use 12.5kg of rice wine or white wine.

experiment example 2

[0028] Experimental Example 2 Preparation of Extraction Extract from the Processed Wine Coptis Rhizoma of the Present Invention

[0029] Take wine-roasted Coptis chinensis, add water to decoct 3 times, 3 hours each time, add 10 times the amount of water each time, filter, combine the extracts, concentrate, and set aside.

[0030] According to the above-mentioned process, extracts of wine-burned Coptis chinensis and raw Coptis chinensis were extracted and prepared, and the content of total polysaccharides was also determined on the basis of the determination of total alkaloids.

[0031] Determination method of total alkaloids: Accurately weigh 0.4g of the extract, put it into a 25mL measuring bottle, add ethanol to dilute to the mark, shake well, and test by column chromatography. Precisely measure 5mL, put it on the treated alumina column (about 0.9cm inner diameter, 5g neutral alumina, wet packing, pre-wash with 30mL ethanol), elute with 35mL ethanol, collect the eluate and p...

Embodiment 3

[0036] Example 3 Quality Control Method of Wine Sunburned Coptidis Rhizome

[0037] (1) TLC identification

[0038]Take 0.1g of this product powder, add methanol 50ml, ultrasonic treatment for 30min, and the filtrate is used as the test solution. Take jatrorrhizine hydrochloride, tetrandrine hydrochloride, epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride and berberine hydrochloride plus methanol to make a solution containing 0.1 mg per 1 ml, as a reference solution. Precisely measure 1.5ml of each reference substance solution and add it to the same 10ml measuring bottle, dilute to the mark with methanol, and use it as a mixed reference substance solution. According to the test of thin-layer chromatography (Appendix VI B of the Chinese Pharmacopoeia in 2005), draw 10 μl of each of the above-mentioned three solutions, respectively spot on the same silica gel G thin-layer plate, and use cyclohexane-ethyl acetate-isopropanol- Methanol-ammonia water-tr...

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Abstract

The invention provides application of wine-roasted Chinese goldthread in preparing medicaments containing insulin sensitizers and PPAR gamma activators. The wine-roasted Chinese goldthread has the functions of inhibiting the differentiation of 3T3-L1 pre-adipocytes, improving the utilization rate of glucose of the 3T3-L1 pre-adipocytes or reducing blood fat as the insulin sensitizers and the application in improving insulin resistance or treating diabetes mellitus. The invention also provides a medicine composition having the functions of inhibiting the differentiation of 3T3-L1 pre-adipocytes and improving the utilization rate of the glucose of the 3T3-L1 pre-adipocytes. The wine-roasted Chinese goldthread and extracts thereof are the medicaments having the function of inhibiting the differentiation of 3T3-L1 pre-adipocytes, can be used for improving insulin resistance and treating the diabetes mellitus and complications thereof and have a specific effect better than that of berberine hydrochloride and crude Chinese goldthread.

Description

technical field [0001] The invention relates to a new application of wine-cured Coptidis rhizoma, in particular, the application in the preparation of drugs for insulin sensitizers and PPARγ agonists. Background technique [0002] According to the World Health Organization's "2008 World Health Report": the combination of urbanization, aging and global lifestyle changes has made chronic non-communicable diseases such as diabetes an increasingly important cause of disease and death. According to the "Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2007 Edition)" issued by the Diabetes Society of the Chinese Medical Association: Type 2 diabetes is the main type (93.7%) of the diabetic population in China, and it is expected to reach 55 million people in 2025. Diabetes belongs to the category of "diabetes" disease in traditional Chinese medicine. According to the theory of traditional Chinese medicine, the pathogenesis of "diabetes" is: due to eating too...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P5/50A61P3/06A61P3/10A61K125/00
Inventor 赖先荣孟宪丽张艺李佳川郑海杰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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