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Fluorapatite coating and preparation method thereof

A fluoroapatite coating technology, applied in the field of fluoroapatite coating, can solve the problems of poor long-term stability and achieve high biological activity

Inactive Publication Date: 2010-10-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The artificially prepared HAP has a certain solubility in body fluids and has poor long-term stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Add 2.7ml of AcOH (2mol / l) and 1.8ml of NaOH (2mol / l) solution to 7.3ml of distilled water, weigh 0.0525g NaF and 1.3425g NaF 2 HPO 4 12H 2 O powder, dissolved in the above solution successively, then add 8.2g of glycerol with a volume fraction of 85%, after stirring evenly, add 2.25g of gelatin, after absorbing water and swelling and softening, heat it in a water bath to 60°C, completely dissolve and stir evenly , cooled to room temperature to prepare an ion-coated gel;

[0018] 2) Add 8.2g of glycerol with a volume fraction of 85% to 11.8ml of distilled water, stir evenly, then add 2.25g of gelatin, after absorbing water to swell and soften, heat in a water bath to 60°C, completely dissolve and stir evenly, Cool to room temperature to make shielding layer gel;

[0019] 3) The gels obtained in steps 1) and 2) are successively coated on the sintered HAP substrate in the polytetrafluoroethylene tube, and the thickness is 2-3mm;

[0020] 4) Put the reaction system ...

Embodiment 2

[0025] 1) Add 2.7ml of AcOH (2mol / l) and 1.8ml of NaOH (2mol / l) solution to 7.3ml of distilled water, weigh 0.0525g NaF and 1.3425g NaF 2 HPO 4 12H 2 O powder, dissolved in the above solution successively, then add 8.2g of glycerol with a volume fraction of 85%, after stirring evenly, add 2.5g of gelatin, after absorbing water and swelling and softening, heat it in a water bath to 60°C, completely dissolve and stir evenly , cooled to room temperature to prepare an ion-coated gel;

[0026] 2) Add 8.2g of glycerol with a volume fraction of 85% to 11.8ml of distilled water, stir evenly, then add 2.5g of gelatin, after absorbing water to swell and soften, heat in a water bath to 60°C, completely dissolve and stir evenly, Cool to room temperature to make shielding layer gel;

[0027] 3) The gels obtained in steps 1) and 2) are successively coated on the sintered HAP substrate in the polytetrafluoroethylene tube, and the thickness is 2-3mm;

[0028] 4) Put the reaction system in...

Embodiment 3

[0034] 1) Add 2 mol / l of AcOH and 2 mol / l of NaOH to 36.5 ml of distilled water according to the acid-base volume ratio of 3:2; weigh NaF and Na 2 HPO 4 12H 2 O, dissolved in the above solution successively, and then press glycerol and the above H 2 The mass ratio of O+AcOH+NaOH is that the amount of 45% is added the glycerin that volume fraction is 85%, after stirring evenly, press gelatin and above-mentioned glycerol+H 2 The mass ratio of O+AcOH+NaOH is 20% and gelatin is added. After it absorbs water and swells and softens, heat it in a water bath to 60°C, stir until it is completely dissolved, and cool to room temperature to obtain coated HPO. 4 - and F - ion gel;

[0035] 2) Take distilled water equal to the volume of distilled water+AcOH+NaOH described in step 1), add glycerol with a volume fraction equal to 85% in step 1), stir evenly, and add the same amount as in step 1). Equal amount of gelatin, after it absorbs water and swells and softens, heat it in a water ...

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Abstract

The invention discloses a fluorapatite coating which is prepared by ion coated gel preparation, shielding layer gel preparation and biomineralization process. The fluorapatite coating has higher bioactivity, biocompatibility and synostosis capability, and effectively overcomes the defects of the existing implanted materials.

Description

technical field [0001] The invention belongs to the intersecting fields of material science, bionics and biomedicine, and relates to a fluoroapatite coating which simulates the internal environment of a human body and is prepared by a biomineralization method. Background technique [0002] At present, most of the commonly used materials for human hard tissue repair and implantation in medicine are metal materials with good comprehensive mechanical properties and excellent processing properties, such as medical stainless steel, titanium and its alloys, and cobalt-chromium-molybdenum alloys. Due to the poor biocompatibility and corrosion resistance of metal materials in the human body, and the metal ions produced by corrosion will have adverse effects on human tissues and organs, such materials are usually surface modified or modified before clinical application. . Apatite (containing hydroxyapatite (HAP), fluorapatite (FAP), and carbonate apatite) is the main inorganic compo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32
Inventor 孙康宁王洪友徐欣梁延杰
Owner SHANDONG UNIV
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